First published in 1925, this two-volume work deals with the blood's role in respiration. This first volume analyses the effect of high altitudes on the blood's ability to retain and diffuse oxygen. The text is illustrated with diagrams, maps and photographs relating to the changes human physiology undergoes at altitude, including changes in circulation rate, pulse and the nature of red corpuscles. This book will be of value to anyone with an interest in the history of medicine or in haematology.

First published in 1925, this two-volume work deals with the blood's role in respiration. This second volume deals with haemoglobin as a chemical substance. The text is illustrated with diagrams and drawings relating to, among other things, haemoglobin's specificity, its manufacture in the body and how it is affected by temperature changes. This book will be of value to anyone with an interest in the history of medicine or in haematology.

George Henry Falkiner Nuttall (1862–1937) was an American-British bacteriologist who made significant contributions to various aspects of medicine. In this book, which was first published 1904, Nuttall provides a record of investigations carried out in the Pathological Laboratory of the University of Cambridge, chiefly during 1902. The text presents a demonstration of blood relationships among animals by means of the precipitin test for blood. A bibliography is also included. This book will be of value to anyone with an interest in haematology and the history of science.

 A concise, clinical handbook covering the whole of haematology Reflects current practice with up-to-date investigation and management Easy-to-understand and useful for all grades of medical, nursing, technical, and research staff Includes rare disorders as well as common conditions affecting both adults and children Practically focused, written by a team of experienced, practicing clinicians New to this edition Contains all the latest guidelines and a brand new chapter on rare diseases All sections and protocols on malignant haematology have been completely revised Covers all major advances in the specialty including mlaignant haematology and transfusion medicine The Oxford Handbook of Clinical Haematology provides core and concise information on the entire spectrum of blood disorders affecting both adults and children. Updated for its fourth edition, it includes all major advances in the specialty, including malignant haematology, haemato-oncology, coagulation, transfusion medicine, and red cell disorders, with a brand new chapter on rare diseases. Practically focused, and specifically designed for ease-of-use, and rapid access to the information you need, this handbook is an indispensable resource on all aspects of haematology for all trainee doctors, nurses, technicians, and research professionals. The handbook is divided into clinical approach and disease-specific areas. The clinical approach section outlines various symptoms and signs in patients with blood disease to enable the reader to formulate a sensible differential diagnosis beofre embarking on investigation and treatment. The disease-specific section is written by four authors whose expertise covers the whole breadth of diseases included in the book. All authors have contributed to national guidelines (e. g. British Committee for Standards in Haematology, BCSH) and are experts in the evidence base that exists for each topic. The Oxford Handbook of Clinical Haematology offers a concise and logical approach to caring for patients with diseases of the blood. 1: Clinical approach 2: Red cell disorders 3: White blood cell abnormalities 4: Leukaemia 5: Lymphoma 6: Myelodysplasia 7: Myeloproliferative neoplasms (MPNs) 8: Paraproteinaemias 9: Haematopoietic stem cell transplantation (SCT) 10: Haemostasis and thrombosis 11: Immunodeficiency 12: Paediatric haematology 13: Haematological emergencies 14: Supportive care 15: Protocols and procedures 16: Haematological investigations 17: Blood transfusion 18: Rare diseases A1: Haematology online A2: Charts and nomograms A3: Normal ranges

Concise, portable, and user-friendly, The Washington Manual Hematology and Oncology Subspecialty Consult, 4th Edition, provides quick access to the essential information needed to evaluate a patient on a subspecialty consult service. This edition offers state-of-the-art content, including coverage of new anti-cancer drugs and new biomarkers and therapeutic targets. Ideal for fellows, residents, and medical students rotating on hematology and oncology subspecialty services, the manual is also useful as a first-line resource for internists and other primary care providers.

Key Features:
*Thoroughly revised to include new standards in the treatment of malignancies and hematologic disorders, mechanisms of action of new therapeutic agents, and the current use of molecular prognostic factors.
* A new chapter on immunotherapy reviews approved and potentially approved new therapies that help you improve clinical outcomes for your patients.
* A reorganized, consistent format throughout ensures that you can find what you need quickly and easily.
*Comprehensive coverage addresses all areas of hematology and oncology.
* Symptoms, signs, and problems encountered in daily practice are presented in a quick-reference bulleted format
*Updated references are provided for readers who would like additional information on a particular topic.
* Written by fellows and junior faculty from the Washington University School of Medicine in St. Louis.Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like:

*Complete content with enhanced navigation
*Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web
*Cross-linked pages, references, and more for easy navigation
*Highlighting tool for easier reference of key content throughout the text
* Ability to take and share notes with friends and colleagues
*Quick reference tabbing to save your favorite content for future use

Bridging the gap between science and clinical practice, The Bethesda Handbook of Clinical Hematology, Fourth Edition, provides concise, up-to-date coverage of ?need to know? information on the diagnosis and treatment of blood and bone marrow disorders. Written by nationally recognized experts and senior fellows at the National Institutes of Health, and at leading research institutions throughout the United States, this essential pocket reference is logically organized by disease category and features a reader-friendly format that includes tables, algorithms, illustrations, and bulleted lists that highlight key information. ? Discusses the pathophysiology, natural history, risk factors, diagnosis, management, and follow-up of common hematological diseases. ? Contains new information on diagnosis, treatment and management of myelodysplastic and myeloproliferative disorders; leukemias and lymphomas; disorders of hemostasis and thrombosis. Features new diagnostic and treatment strategies, updated references, and revised information throughout. ? Ideal for the student, resident, or fellow on a hematology or oncology service, as well as the internist, hospitalist, family practitioner, and pediatrician who sees patients with blood diseases. ? Perfect as an everyday reference or for board review. ? Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! ? Read directly on your preferred device(s), such as computer, tablet, or smartphone ? Customize for your language, including right-to-left reading, vertical writing, and enhanced annotation in over 30 languages ? Easily convert to audiobook, powering your content with natural language text-to-speech ? Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time th

Hoffbrand s Essential Haematology has built a reputation as the flagship haematology textbook for both students and junior doctors, providing an authoritative introduction to the subject. Now in its 7th edition, this classic text provides up–to–date knowledge of the pathogenesis, clinical and laboratory features, treatment of blood and bone marrow disorders, in its concise and user–friendly style. Hoffbrand s Essential Haematology outlines the basic principles of clinical and laboratory haematology and shows how manifestations of blood diseases can be explained by new knowledge of the disease processes. It is an indispensable resource for students and trainees and an essential read for all specialists who are interested in updating their knowledge. Hoffbrand s Essential Haematology: Provides up–to–date knowledge of the pathogenesis, clinical and laboratory features and treatment of all blood disorders Features detailed information on the new genetics of leukaemia and lymphoma Includes a new chapter on thrombosis, focussing on the new oral anticoagulants Is beautifully presented, with over 300 colour illustrations Comprehensively covers both theory and treatment regimes Includes a companion website at www.wileyessential.com/haematology featuring all the figures and tables from the book, and over 300 interactive multiple choice questions

This book provides a unique frame work for examining acute lung syndromes that arise from hematologic disorders or is defined by a hematologic abnormality as a key feature.  Acute lung processes arising from hematologic disorders can present as life-threatening conditions, and as such, the pulmonary physician or critical care physician are often directly involved in care or called upon to provide expertise. Chapters are organized into three sections, each with an emphasis on pathogenesis and current understanding of mechanisms. The text begins with the central theme of the lungs as the direct interface between the external environment and blood, description of individual components of the hematopoietic system, their function and relevance to the lungs. The second section outlines both benign and malignant primary hematologic disorders that can lead to acute pulmonary manifestations. The final section focuses on acute lung syndromes stemming from complications of transfusion and treatment. Chapters are presented in an easy-to-access format, providing information on diagnosis, management, and outcomes. This is a valuable resource for pulmonary fellows in training, pulmonologists, critical care physicians, and physicians involved in caring for patients in the ICU.

Featuring hundreds of full-color photomicrographs, Hematology: Clinical Principles and Applications prepares you for a job in the clinical lab by exploring the essential aspects of hematology. It shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. This book also makes it easy to understand complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics. Well-known authors Bernadette Rodak, George Fritsma, and Elaine Keohane cover everything from working in a hematology lab to the parts and functions of the cell to laboratory testing of blood cells and body fluid cells.

This book provides the necessary information about not only the clinical aspects of caring for cancer survivors, but also the psychosocial impacts. There are multiple resources available to serve as oncology textbooks, but nothing to provide the necessary information on patient care for the non-MD members of the cancer patient management team. In the post-treatment phase, the management team must go beyond the realm of "conventional" follow-up, helping the patient to intellectually understand and emotionally grasp the path ahead. Cancer Survivorship will prove a vital tool to physicians, nurses, clinical social workers and mental health.

Designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders. Provides essential practical management for all those working in the field of hemostasis and thrombosis Includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies Covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders Follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading Highlights controversial issues and provides advice for everyday questions encountered in the clinic

 When a biological drug patent expires, alternative biosimilar products are developed. The development of biosimilar products is complicated and involves numerous considerations and steps. The assessment of biosimilarity and interchangeability is also complicated and difficult.Biosimilar Drug Product Development presents current issues for the development of biosimilars and gives detailed reviews of its various stages and contributing factors as well as relevant regulatory pathways and pre- and post-approval issues.

his comprehensive and authoritative text summarizes current evidence and provides experienced perspectives on the etiology, diagnosis, and management of pediatric thrombotic disorders, including arterial ischemic stroke and cerebral sinovenous thrombosis. Authored by leaders in the field, individual chapters are devoted to specific anatomic sites and types of thrombosis. State-of-the-art, pediatric-focused chapters aid in diagnostic evaluation and therapeutic decision making, in settings ranging from the most routine to the most complex and challenging patient scenarios. Topics include: Extremity and Caval Deep Venous Thrombosis; Pulmonary Embolism; Cancer-Associated Thromboembolism; Infection-Associated Thromboembolism; Arterial Ischemic Stroke; Cerebral Sinovenous Thrombosis; Gastrointestinal and Visceral Thrombosis; Developmental Hemostasis; Thrombophilias; Heparin-Induced Thrombocytopenia/Thrombosis Syndrome; Venous Thromboembolism Prevention; Thrombolysis; and Novel Anticoagulants, among others. This text is a 'must-have' for practitioners in pediatric hematology, oncology, hematopoietic stem cell transplantation, neurology, hospital medicine, and intensive care.

The fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert haematologists, including new co-editor Mark H. Yazer MD.

·         A succinct and user-friendly resource of transfusion medicine for clinicians, scientists and trainees with key points, charts and algorithms

·         Discusses practice in blood centres and hospitals including regulatory aspects, transfusion safety, production and storage, donor care, and blood transfusion in a global context

·         Coverage of cellular and tissue therapies and organ transplantation including stem cell collection and haematopoietic stem cell processing and storage

·         Review of the development of the evidence-base for transfusion medicine

·         Content on the clinical practice for transfusion and alternatives to transfusion

Covering a full range of topics from cardiovascular and pulmonary disease to ophthalmology, hematology and pediatrics, this is the only single volume, quick reference designed for use in daily practice. The 150+ clinical prediction rules as well as the background information necessary to determine its validity and relevance are essential for every physician in a time of limited health care resources. Designed as an aid in diagnosis and treatment, these rules allow more accurate diagnosis and treatment decisions while eliminating superfluous testing.

Written by a team of international experts, this book provides an authoritative overview and practical guide to the molecular biology and genetic basis of haematologic cancers including leukemia. Focusing on the importance of cytogenetics and related assays, both as diagnostic tools and as a basis for translational research, this is an invaluable guide for basic and clinical researchers with an interest in medical genetics and haemato–oncology.

The Genetic Basis of Haematological Cancers reviews the etiology and significance of genetic and epigenetic defects that occur in malignancies of the haematopoietic system. Some of these chromosomal and molecular aberrations are well established and already embedded in clinical management, while many others have only recently come to light as a result of advances in genomic technology and functional investigation. The book includes seven chapters written by clinical and academic leaders in the field, organised according to haematological malignancy sub–type.
Each chapter includes a background on disease pathology and the genetic abnormalities most commonly associated with the condition. Authors present in–depth discussions outlining the biological significance of these lesions in pathogenesis and progression, and their use in diagnosis and monitoring response to therapy. The current or potential role of specific abnormalities as novel therapeutic targets is also discussed. There is also a full colour section containing original FISH, microarrays and immunostaining images.

​This book is an up-to-date reference on all aspects of anticoagulation and hemostasis in neurosurgery.  After an opening section on basic principles and drug classes in current use, detailed consideration is given to coagulation issues relevant to all patients, not just neurosurgical ones. The coverage includes, for example, deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. A variety of important issues specific to neurosurgical practice are then addressed, and a summary of current guidelines and best practices is provided. By bringing together the latest knowledge from across the discipline, this book will serve as a sound basis for informed decision making in surgical practice. It will be of daily value for neurosurgeons and trainees worldwide and will also be of interest to emergency room physicians, surgeons in general, critical care physicians, neurologists, and hospital medicine specialists.

• Enables both the haematologist and laboratory scientist to identify blood cell features, from the most common to the more obscure
• Provides essential information on methods of collection, blood film preparation and staining, together with the principles of manual and automated blood counts
• Completely revised and updated, incorporating much newly published information: now includes advice on further tests when a specific diagnosis is suspected
• 400 high quality photographs to aid with blood cell identification • Highlights the purpose and clinical relevance of haematology laboratory tests throughout

From the bestselling author, Barbara J. Bain, the new edition of this practical reference on the principles of leukaemia diagnosis and classification has been fully updated, and incorporates the recently revised WHO classification.

Leukaemias are a very heterogeneous group of diseases, which differ from each other in aetiology, pathogenesis, prognosis and responsiveness to treatment. Accurate diagnosis and classification are vital for the identification of specific biological entities and underpin scientific advances in this field. The detailed characterization of haematological neoplasms is also essential for the optimal management of individual patients.

In this user-friendly guide, Professor Bain illustrates and explains how these many laboratory techniques are used for the diagnosis and classification of leukaemia and related disorders. Leukaemia Diagnosis, Fifth Edition will be highly valuable to trainee haematologists and laboratory scientists in haematology and related disciplines, and will also prove a useful reference source and teaching aid for those who already have expertise in this field. In addition, cytogeneticists and molecular geneticists will find that this book enhances their understanding of the relationship of their disciplines to the diagnosis, classification and monitoring of leukaemia and related disorders.

Essential reading for every haematologist and haematopathologist, Leukaemia Diagnosis, Fifth Edition features

• Over 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma supplemented by histological, cytogenetic and immunophenotyping images
• Recent information on cytogenetic and molecular genetic abnormalities in leukaemia
• Updated information on the characteristic immunophenotypic characteristics of different categories of leukaemia

• Provides up-to-date knowledge on the pathogenesis and management of the syndrome
• Presents and discusses innovative treatments in addition to standard treatment options
• Describes the involvement of other organs or organ systems

About this book

This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss/complications are explained.

The main clinical manifestations, classification criteria and diagnostic tools are identified, and close attention is paid to the nature of the involvement of various organs or organ systems in APS. Specific chapters describe the treatment of the different symptoms, therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome.

Reviews

From the book reviews:

“The purpose is to provide an overview of this very difficult subject that will benefit bench researchers as well as bedside clinicians. The book would serve any audience who wants to know more about antiphospholipid syndrome. … This is an excellent, up-to-date overview of antiphospholipid syndrome. It will serve as a handy tool to get more information on the topic.” (Dany V. Thekkemuriyil, Doody’s Book Reviews, February, 2015)

Table of contents (20 chapters)

·         Genetics and Origin of Antiphospholipid Syndrome

Soriano, Alessandra (et al.)

Pages 1-12

·         The Paradox of Lupus Anticoagulant

Banzato, Alessandra (et al.)

Pages 13-23

·         Antiphospholipid Antibody Mechanisms of Thrombosis

Meroni, Pier Luigi (et al.)

Pages 25-35

·         The Pathogenic Mechanisms for Antiphospholipid Antibodies (aPL)-Mediated Pregnancy Loss

Simone, Nicoletta (et al.)

Pages 37-46

·         Classification Criteria for the Antiphospholipid Syndrome

Derksen, Ronald H. W. M. (et al.)

Pages 47-59

·         Non-classification Criteria

Gerosa, Maria (et al.)

Pages 61-74

·         Obstetric APS

Fredi, Micaela (et al.)

Pages 75-87

·         APS and the Nervous System

Chighizola, Cecilia Beatrice (et al.)

Pages 89-102

·         Antiphospholipid Syndrome (APS) and the Renal Involvement

Mezzina, Nicoletta (et al.)

Pages 103-112

·         Non-Thrombotic Hematologic Manifestations in APS

Barcellini, Wilma (et al.)

Pages 113-126

·         Heart and APS

Denas, Gentian (et al.)

Pages 127-150

·         Skin Involvement in Antiphospholipid Syndrome

Marzano, Angelo Valerio (et al.)

Pages 151-161

·         Additional Organs Involved in Antiphospholipid Syndrome: Eye, Ear-Nose-Throat, Lung, Gastroenteric System, Endocrine Glands

Santis, Maria (et al.)

Pages 163-168

·         Differential Diagnosis

Prisco, Domenico (et al.)

Pages 169-184

·         Treatment of Thrombosis in Antiphospholipid Syndrome

Braham, Simon (et al.)

Pages 185-192

·         Treatment of Pregnancy Complications

Acaia, Barbara (et al.)

Pages 193-206

·         Antiphospholipid Antibody Carriers

Dall’Ara, Francesca (et al.)

Pages 207-218

·         New Treatments

Chighizola, Cecilia Beatrice (et al.)

Pages 219-232

·         Secondary Antiphospholipid Syndrome

Rahman, Anisur (et al.)

Pages 233-248

·         The

Rodríguez-Pintó, Ignasi (et al.)

Pages 249-262

The first book on clinical guide to transplantation in lymphoma to present cutting edge knowledge on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies • Provides practical management guidance on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies • Covers an overview of transplantation in lymphoma, and management of the lymphoid malignancies • Discusses organizational aspects of transplant patients and managing a transplant program • Appendices provide practical quick-reference information on follow-up after autologous and allogenic stem cell transplantation in lymphoma

• A clinically oriented, compact, and up-to-date overview on all aspects of infections in hematology patients
• Identifies the typical pathogens to be considered in different subgroups of patients
• Presents clinical, imaging and laboratory-based diagnostic techniques and discusses the therapeutic strategies appropriate to different situations
• Considers various prophylactic strategies

About this book

Infections are among the most frequent complications in patients with hematological malignancies and in those undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation. A profound knowledge on the epidemiology, diagnostic approaches, treatment modalities and prophylactic strategies is essential for the clinical management of these complications in patients who are often severely immunocompromised owing to their underlying diseases and in particular, the intensive myelosuppressive chemo and immunotherapy. This textbook provides a clinically oriented, compact and up-to-date overview on infections in hematology patients and their management. The typical pathogens to be considered in different subgroups of patients are identified and further aspects of the microbiological background are explored.

Clinical, imaging, and laboratory-based diagnostic techniques are discussed and therapeutic strategies appropriate to different situations are then presented, with due attention to the pitfalls, toxicities and interactions that can arise during antimicrobial treatment. Strategies to prevent infection are also outlined, encompassing antimicrobial prophylaxis, isolation procedures, hospital hygiene, protective immunization and the use of hematopoietic growth factors.

Reviews

“This is a comprehensive review of the risk factors, microbiology, prophylaxis, and management of infections in patients with hematological malignancies. … The audience includes students, residents, and practitioners who care for patients with hematological malignancies, and the book targets this group well. … Physicians who care for patients with hematological malignancies need a book like this to give them a comprehensive overview of the support and management of infections in these patients.” (Joseph C. Alvarnas, Doody's Book Reviews, May, 2015)

Table of contents (18 chapters)

·         Infections in Patients with Acute Leukemia

Rolston, Kenneth V. I.

Pages 3-23

·         Infections in Patients with Malignant Lymphomas

Rolston, Kenneth V. I.

Pages 25-37

·         Consequences from Specific Treatment Modalities

Maschmeyer, Georg

Pages 39-47

·         Infections After High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation

Nucci, Marcio (et al.)

Pages 49-61

·         Microbiological Background

Akova, Murat

Pages 63-87

·         The Diagnostic Approach to the Febrile Neutropenic Patient: Clinical Considerations

Bow, Eric J.

Pages 91-111

·         Diagnostic Radiology in Hematological Patients with Febrile Neutropenia

Heussel, Claus Peter

Pages 113-135

·         Risk Stratification in Febrile Neutropenic Patients

Paesmans, Marianne

Pages 137-152

·         Fever of Unknown Origin: Treatment According to Risk Assessment

Maschmeyer, Georg

Pages 155-163

·         Pulmonary Complications

Maschmeyer, Georg

Pages 165-185

·         Vascular Catheter-Related Infections

Dababneh, Luma (et al.)

Pages 187-195

·         Gastrointestinal Complications

Blijlevens, Nicole M. A.

Pages 197-210

·         Central Nervous System Infections

Schmidt-Hieber, Martin

Pages 211-226

·         Antibacterial Agents

Kern, Winfried V.

Pages 229-258

·         Antifungal Agents

Thompson, George R. (et al.)

Pages 259-272

·         Antimicrobial Prophylaxis in Hematology

Girmenia, Corrado (et al.)

Pages 275-296

·         Infection Control and Hospital Epidemiology in Hematology Units

Weisser, Maja (et al.)

Pages 297-313

·         Myeloid Growth Factors

Link, Hartmut

Pages 315-324

With authoritative coverage of rare and common hemostatic disorders, Consultative Hemostasis and Thrombosis, 4th Edition, keeps you both up to date with all that?s new in this fast-moving field as well as reviewing background and development and citing pertinent classical literature. Broad differential diagnoses are provided, underscoring the editors? position that correct treatment begins with correct diagnosis. This trusted resource by Drs. Craig S. Kitchens, Craig M. Kessler, Barbara A. Konkle, Michael B. Streiff, and David A. Garcia is designed for rapid reference and critical decision making at the point of care. Features: ? Emphasizes real-world problems and solutions, with quick access to concise descriptions of each condition, associated symptoms, laboratory findings, differential diagnosis, and treatment. ? Features a user-friendly design, full-color format, abundant laboratory protocols, and at-a-glance tables and charts throughout. New To This Edition: ? Provides thorough updates on core information on hemostasis and thrombosis, including deep venous thrombosis (DVT), pulmonary embolisms, hypercoagulability, thrombocytopenia, von Willenbrand disease, and more. ? Covers new treatment information on hemophilia A and B. ? Contains new chapters on hereditary hemorrhagic telangiectasia, hemolytic uremic syndrome, and paroxymal nocturnal hemoglobinuria. ? Two new editors, Dr. Michael B. Streiff and Dr. David A. Garcia, offer fresh perspectives and valuable experience. ? Expert Consult? eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

This authoritative new book provides a comprehensive overview of diagnostic and therapeutic strategies in hematopoietic cell transplantation, explaining key concepts, successes, controversies and challenges. The authors and editors discuss current and future strategies for major challenges, such as graft-versus-host-disease, including new prophylaxis and treatments. They also discuss long-term complications, such as second malignancies and cardiovascular complications. Chapters are written by leading world experts, carefully edited to achieve a uniform and accessible writing style. Each chapter includes evidence-based explanations and state-of-the-art solutions, providing the reader

Hematologic malignancies were the first human cancers to be studied in depth at the molecular level, and recent years have seen important advances in treatment. This comprehensive reference book covers the full range of hematologic malignancies, including all subtypes of leukemias, lymphomas, and plasma cell dyscrasias. Authored by internationally known experts, each chapter emphasizes diagnostic work-up, staging, and therapeutic approaches. Up-to-date hematopathology, treatment, and outcomes data are presented in a way which is directly applicable to patient care. Highly illustrated with color images, graphs, flowcharts and treatment algorithms, the book is perfect for quick clinical reference as well as providing detailed reference lists for further study. With its authoritative and practical focus and visually stimulating presentation, this is a key text for hematology and oncology fellows, physicians, oncology nurses, physician assistants and other healthcare workers in the field of oncology. Covers epidemiology, etiology, risk-factors, clinical presentation, diagnosis, staging and treatment strategies for each disease subset Color images, graphs, flowcharts, algorithms and tables enhance the presentation and clinical utility of the text Extensive reference lists enable further reading and study

Provides coverage of the pathogenesis, clinical, morphologic, molecular and investigational aspects of a full range of blood disorders seen in daily practice The revised fifth edition of this renowned atlas presents readers with a comprehensive, visual guide to clinical hematology, featuring 2700 full-color photographs and figures depicting the spectrum of hematological diseases. Ranging from photographs of the clinical manifestations and key microscopic findings to diagrams of the molecular aspects of these diseases, the book provides up-to-date information of the blood diseases that clinicians encounter every day. Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease offers the reader an understanding of normal cell machinery, and of the molecular basis for such processes as DNA and cell replication, RNA species, trafficking and splicing, protein synthesis, transcription factors, growth factor signal transduction, epigenetics, cell differentiation, autophagy, and apoptosis. The text goes on to explore how these processes are disturbed in the various diseases of the bone marrow, blood, and lymphoid systems. Helps solve difficult diagnostic challenges and covers complex principles using highly illustrative, full-color images Explores all aspects of benign and malignant hematology, including blood transfusion and coagulation with extensive coverage of the pathogenesis of common clinical entities Provides a quick and easy reference of key diagnostic issues in a comprehensive yet concise format Includes and illustrates the WHO Classification of Hematologic Malignancies Illustrates the new knowledge of the molecular basis of inherited and acquired blood diseases Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease is the must-have resource for both trainee and practising hematologists, and for every department of hematology.

First published in 2006, the bestselling Wintrobe's Atlas of Clinical Hematologyhas now been comprehensively updated by a brand-new editorial team to bring you state-of-the-art pictorial coverage of the complete range of hematologic conditions. Thousands of meticulous, full-color images capture the characteristic appearance of each pathologic entity, and concise descriptions point out features of diagnostic importance. The result is a peerless reference to facilitate confident diagnosis in hematology.

Features:

Access the latest knowledge in the field with more than 30% new or updated content - including expanded coverage of acute lymphoblastic leukemia (ALL); revised diagnostic criteria for fluorescent in situ hybridization (FISH); enhanced information on flow cytometry; new coverage of genetic screens, circulating DNA analysis, RT-PCR, exosome analysis, and evaluation of epigenetic abnormalities; completely new chapters on hemostasis and platelets as well as on plasma cell disorders and on benign diseases of leukocytes, spleen, and immunoglobins; and much more.Vividly visualize the presentation of every hematologic disorder thanks to thousands of crisp, full-color images, hundreds of them new to this edition.Locate the information you need more easily through a new, highly templated format that expedites navigation, as well as a new index of figures by disorder.Easily find additional in-depth answers inside Wintrobe's Clinical Hematology, the best-selling comprehensive reference in the field, since this Atlas now features a parallel organization.Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time - providing a seamless reading experience online or offlinePowerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooksMultiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive designThe ability to highlight text and add notes with one click

Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team.
Features: • Content is templated and divided into three sections -- Scientific Foundations of Radiation Oncology, Techniques and Modalities, and Disease Sites - for quick access to information.
• Disease Sites chapters summarize the most important issues on the opening page and include a full-color format, liberal use of tables and figures, a closing section with a discussion of controversies and problems, and a treatment algorithm that reflects the treatment approach of the authors.
• Chapters have been edited for scientific accuracy, organization, format, and adequacy of outcome data (such as disease control, survival, and treatment tolerance).
• Allows you to examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches.
• Features an emphasis on providing workup and treatment algorithms for each major disease process, as well as the coverage of molecular biology and its relevance to individual diseases.
New To This Edition:

• Two new chapters provide an increased emphasis on stereotactic radiosurgery (SRS) and stereotactic body irradiation (SBRT).
• New Associate Editor, Dr. Andrea Ng, offers her unique perspectives to the Lymphoma and Hematologic Malignancies section.
• Key Points are summarized at the beginning of each disease-site chapter, mirroring the template headings and highlighting essential information and outcomes.
• Treatment algorithms and techniques, together with discussions of controversies and problems, reflect the treatment approaches employed by the authors.
• Disease Site Overviews allow each section editor to give a unique perspective on important issues, while online updates to Disease Site chapters ensure your knowledge is current.
• Disease Site chapters feature updated information on disease management and outcomes.
• Four videos accessible on Expert Consult include Intraoperative Irradiation, Prostate Brachytherapy, Penile Brachytherapy, and Ocular Melanoma.
• Thirty all-new anatomy drawings increase your visual understanding.
• Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

Written by the leading names in pediatric oncology and hematology, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color, two-volume set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski’s is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.

Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field.

This extensive title, which combines scientific principles with up-to-date clinical procedures, has been thoroughly updated for the fourteenth edition. You?ll find in-depth material on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. ? Combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders in one volume. ? Access the latest knowledge in genetics and genomics ? eBook features 300 online self-assessment questions for reviewing material and preparing for Board exams. ? Packed with more than 1,500 tables and figures. Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! ? Read directly on your preferred device(s), such as computer, tablet, or smartphone. ? Easily convert to audiobook, powering your content with natural language text-to-speech. ? Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more.

Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. · Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research · Combines the knowledge and expertise of over 170 international specialists across 106 chapters · Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance ·Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more