pe pagina
  • Living with Itch. A Patient s Guide
    La comanda in aproximativ 4 saptamani
    85.00 lei

    We have all experienced itch, whether from insect bites or dry skin, but millions of people worldwide have chronic or even intractable itch. Just like chronic pain, chronic itch interferes with function – even with quality of life. "Living with Itch" offers relief, drawing on the authors' vast knowledge of itch, the suffering it causes, and available treatments. Itch researchers and clinicians Drs. Gil Yosipovitch and Shawn G. Kwatra explain what itch is and the cascade of physiological events that cause us to experience it. They describe the many skin diseases, from atopic dermatitis (also known as eczema) to psoriasis, and conditions like chronic kidney disease, lymphoma, HIV, and neuropathies that cause itch. "Living with Itch" provides information on preventing itch as well as topical and systemic therapies, regardless of what's causing the itch. Patient and parent narratives explain how itch affects their lives and how they cope with a symptom that can, with medical and social support, be managed.

  • 130.00 lei

    This book represents a new and hopeful paradigm for treatment of diseases that are spreading globally as countries adopt Western lifestyles and standards of living. It describes the phenomenal science and clinical efficacy of the work of Dr Xiu-Min Li across a broad array of immune and inflammatory diseases. These include food allergies, asthma, eczema, "new" diseases such as mast cell disorders, obesity, and mental health problems that are part of a worldwide "epidemic of progress". The most allergic people are caught in a cycle of medication, steroid dependency, emergency hospitalization, and curtailing their activities and diets to avoid triggers. Children are "losing their childhoods." They are fighting a battle against diet, climate change, and environmental degradation. Dr Li offers them hope by healing the entire immune system, not just address symptoms. In her practice Dr Li treats complex combinations of allergic diseases for all ages, from infancy through adulthood, bringing relief to people who have suffered terribly from oozing, bleeding skin, desperate breathing disorders, and life-threatening food allergies. She uses her vast knowledge of biochemistry to improve on the traditional decoctions to create refined versions suitable for modern tastes and lifestyles. In contrast with Western pharmaceuticals, which are the study of "one molecule's effects on one other molecule" Dr Li's work shows the effects of multiple molecules on multiple other molecules. Increasing numbers of scientists are beginning to see the possibilities for their own research, with the prospects for more collaborations with prestigious institutions around the world.

  • Master Medicine: Immunology, A core text with self-assessment
    by Edgar
    La comanda in aproximativ 4 saptamani
    17000lei 150.00 lei

    This title is directed primarily towards health care professionals outside of the United States. This series of books reflects the trend towards a core curriculum and self-directed learning. The content is restricted to the 'must know' core information presented in a synoptic style. The diagrams that support the text are in a style that the reader can remember and reproduce in examinations. Each chapter ends with a selection of self-assessment material and full explanatory answers. These consolidate and expand on the chapter contents. This volumes presents an integrated coverage of basic and clinical immunology. Despite the use of problem- and/or topic-based curricula students still respond to the security of a well-ordered presentation of the basic information by traditional discipline.

  • 17900lei 165.00 lei



    Crash Course – your effective every-day study companion PLUS the perfect antidote for exam stress! Save time and be assured you have the essential information you need in one place to excel on your course and achieve exam success.

    A winning formula now for over 20 years, each series volume has been fine-tuned and fully updated – with an improved full-colour layout tailored to make your life easier. Especially written by senior students or junior doctors – those who understand what is essential for exam success – with all information thoroughly checked and quality assured by expert Faculty Advisers, the result are books which exactly meet your needs and you know you can trust.

    Each chapter guides you succinctly through the full range of curriculum topics, integrating clinical considerations with the relevant basic science and avoiding unnecessary or confusing detail. A range of text boxes help you get to the hints, tips and key points you need fast! A fully revised self-assessment section matching the latest exam formats is included to check your understanding and aid exam preparation. 

    Series volumes have been honed to meet the requirements of today’s medical students, although the range of other health students and professionals who need rapid access to the essentials of haematology and immunology will also love the unique approach of Crash Course. Whether you need to get out of a fix or aim for a distinction Crash Course is for you!

    • Provides the exam syllabus in one place - saves valuable revision time
    • Written by senior students and recent graduates - those closest to what is essential for exam success
    • Quality assured by leading Faculty Advisors - ensures complete accuracy of information
    • Features the ever popular 'Hints and Tips' boxes and other useful aide-mémoires - distilled wisdom from those in the know
    • Updated self-assessment section matching the latest exam formats – confirm your understanding and improve exam technique fast


    ·  1: Principles of haematology

    ·  Principles

    ·  Blood

    ·  Blood cells

    ·  Haematopoiesis

    ·  Bone marrow

    ·  The spleen

    ·  Lymphadenopathy

    ·  2: Red blood cells and haemoglobin

    ·  Erythrocytes

    ·  Erythropoiesis

    ·  Haemoglobin

    ·  Myoglobin

    ·  Iron and haem metabolism

    ·  Haemoglobin metabolism

    ·  Red cell cytoskeleton

    ·  Red cell metabolism

    ·  Methaemoglobinaemia

    ·  Full blood count and reticulocyte count

    ·  Peripheral blood film

    ·  3: Red blood cell disorders

    ·  Anaemia

    ·  Anaemia secondary to haematinic deficiency

    ·  Anaemia of chronic disease

    ·  Anaemia due to blood loss

    ·  Microcytic anaemia: other causes

    ·  Haemolytic anaemia

    ·  Antibody-mediated haemolysis

    ·  Intrinsic red cell defects causing haemolysis

    ·  Other causes of haemolysis

    ·  Haemoglobinopathies

    ·  Electrophoresis: investigation of haemoglobinopathies

    ·  Marrow defects causing anaemia

    ·  Polycythaemia

    ·  4: White blood cells

    ·  Leucocyte structure

    ·  Leucocyte differentiation

    ·  Left and right shift

    ·  White count differential

    ·  Leucocytosis

    ·  Leucopenia

    ·  5: Haematological malignancies

    ·  Introduction

    ·  Myeloproliferative neoplasms

    ·  Myelodysplastic syndromes

    ·  Leukaemias

    ·  Acute leukaemias

    ·  Chronic leukaemias

    ·  Malignant lymphomas

    ·  Age-specific haematological malignancy risk

    ·  Plasma cell dyscrasi as

    ·  Investigations in haematological malignancy

    ·  Chemotherapy and targeted treatments

    ·  6: Haemostasis

    ·  Introduction

    ·  Platelets

    ·  Antiplatelet drugs

    ·  Platelet disorders

    ·  The coagulation cascade

    ·  Traditional pathways

    ·  Currently accepted pathway

    ·  Regulation of coagulation

    ·  Fibrinolysis

    ·  Overview of haemostasis

    ·  Coagulation assays

    ·  Clotting factor disorders

    ·  Hereditary factor deficiencies

    ·  Thrombosis

    ·  Secondary (acquired) thrombophilias

    ·  Primary (hereditary) thrombophilias

    ·  Venous thromboembolism

    ·  Anticoagulation

    ·  Thromboprophylaxis

    ·  Therapeutic fibrinolysis

    ·  7: Transfusion products

    ·  Introduction

    ·  Red cell antigens

    ·  The ABO antigen system

    ·  The Rh antigen (previously termed ‘rhesus antigen’) system

    ·  Other red cell antigens

    ·  Red cell transfusions

    ·  Alternatives to red cell transfusions

    ·  Other transfusion products

    ·  Transfusion complications

    ·  Massive haemorrhage

    ·  8: Principles of immunology

    ·  An introduction to immunology

    ·  9: The innate immune system

    ·  Barriers to infection

    ·  Cells of innate immunity

    ·  Soluble proteins

    ·  Innate immune system pattern recognition molecules

    ·  10: The adaptive immune system

    ·  The immunoglobulin domain

    ·  Generation of antigen receptor diversity

    ·  Humoral immunity

    ·  Cell-mediated immunity

    ·  Tolerance

    ·  11: The functioning immune system

    ·  Response to tissue damage

    ·  Immune response to pathogens

    ·  12: Immune dysfunction

    ·  Hypersensitivity

    ·  Type I hypersensitivity (immediate hypersensitivity)

    ·  Type II hypersensitivity

    ·  Type III hypersensitivity (immune complex)

    ·  Type IV hypersensitivity (delayed-type hypersensitivity)

    ·  Development of hypersensitivity

    ·  Immune deficiency

    ·  Investigation of immune function

    ·  13: Medical intervention

    ·  Immunization

    ·  Transplantation

    ·  Antiinflammatory drugs

    ·  Advanced immunotherapy

    ·  Single best answer (SBA) questions

    ·  Chapter 1  Principles of haematology

    ·  Chapter 2  Red Blood cells and haemoglobin

    ·  Chapter 3  Red blood cell disorders

    ·  Chapter 4  White blood cells

    ·  Chapter 5  Haematological malignancies

    ·  Chapter 6  Haemostasis

    ·  Chapter 7  Transfusion products

    ·  Chapter 9  The innate immune system

    ·  Chapter 10  The adaptive immune system

    ·  Chapter 11  The functioning immune system

    ·  Chapter 12  Immune dysfunction

    ·  Chapter 13  Medical intervention

    ·  Extended-matching questions (EMQs)

    ·  Chapter 1  Principles of haematology

    ·  Chapter 2  Red Blood cells and haemoglobin

    ·  Chapter 3  Red blood cell disorders

    ·  Chapter 5  Haematological malignancies

    ·  Chapter 6  Haemostasis

    ·  Chapter 7  Transfusion products

    ·  Chapter 9  The innate immune system

    ·  Chapter 10  The adaptive immune system

    ·  Chapter 11  The functioning immune system

    ·  Chapter 12  Immune dysfunction

    ·  Chapter 13  Medical intervention

    ·  SBA answers

    ·  Chapter 1  Principles of haematology

    ·  Chapter 2  Red Blood cells and haemoglobin

    ·  Chapter 3  Red blood cell disorders

    ·  Chapter 4  White blood cells

    ·  Chapter 5  Haematological malignancies

    ·  Chapter 6  Haemostasis

    ·  Chapter 7  Transfusion products

    ·  Chapter 9  The innate immune system

    ·  Chapter 10  The adaptive immune system

    ·  Chapter 11  The functioning immune system

    ·  Chapter 12  Immune dysfunction

    ·  Chapter 13  Medical intervention

    ·  EMQ answers

    ·  Chapter 1  Principles of haematology

    ·  Chapter 2  Red Blood cells and haemoglobin

    ·  Chapter 3  Red blood cell disorders

    ·  Chapter 5  Haematological malignancies

    ·  Chapter 6  Haemostasis

    ·  Chapter 7  Transfusion products

    ·  Chapter 9  The innate immune system

    ·  Chapter 10  The adaptive immune system

    ·  Chapter 11  The functioning immune system

    ·  Chapter 12  Immune dysfunction

    ·  Chapter 13  Medical intervention

  • 20200lei 170.00 lei

    This new edition of Clinical Immunology and Allergy is a practical and clinically based guide for clinicians and laboratory staff to aid diagnosis and management of immunological and allergic disease, and provides examples of the correct selection and interpretation of immunological tests for a wide range of conditions. Fully updated from the previous edition, with the addition of new diseases recently identified from the use of genetic testing, and novel biological therapies and autoantibody tests, this title covers the entire breadth of the field, with the information at your fingertips. Split into two sections, the first covering individual diseases and allergies, with diagnosis and management strategies, and the second describing appropriate laboratory tests and their interpretation, the Oxford Handbook of Clinical Immunology and Allergy is an invaluable reference text, and works as a succinct revision guide for the FRCPath in Immunology. Filled with cross-references to create a cohesive overview of a complex subject, and presented in concise bullet-points for detailed direction to the key facts, this handbook provides everything you need to help you in clinical practice.

  • 200.00 lei

    Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible. The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed - from microbiology to cytopathology to transfusion science. Clinical Immunology gives the new biomedical scientist an insight into the function of the immune system, the front line of defence against pathological disease, and the diagnostic techniques used to identify associated malfunctions and disorders. By examining the key immunological principles and scientific basis of laboratory techniques with a focus on the biomedical scientist's role in the diagnostic laboratory, the reader is provided with everything needed to prepare for a specialist qualification in immunology. Current tests, the rationale behind their use, the technologies employed, and the quality measures applied are illustrated by specific case studies showing how the clinician interprets the results to help the patient. Online Resource Centre The Online Resource Centre to accompany Clinical Immunology features: For registered adopters of the book: - Figures from the book, available to download For students: - Answers to self-check and end of chapter questions - Video podcasts including interviews with practicing biomedical scientists and 'in the lab' footage showing biomedical science in practice

  • Immunology for Medical Students, 3rd Edition
    by Helbert
    La comanda in aproximativ 4 saptamani
    23600lei 215.00 lei


    Comprehensive yet concise and easy to read, this updated edition of Immunology for Medical Students effectively explains complex immunology topics and their relevance in clinical practice. Boasting just the right amount of detail for today's busy medical student, it delivers state-of-the-art coverage of the latest scientific and clinical knowledge in the field. Detailed and explanatory illustrations, combined with clinically relevant examples and cases, offer a unique understanding of the human immune system and its role in protecting us from disease.

    • Designed with a clear focus on the needs of medical students.
    • Includes overview illustrations at the beginning of each chapter, as well as illustrations with dialogue boxes.
    • Immunology icons are repeated throughout the text, accompanied by a helpful Icon Key.
    • Detailed clinical cases demonstrate real-world applications.
    • Technical boxes point out important scientific advances.
    • End-of-chapter checklists of learning points facilitate review.
    • Features 17 new clinical boxes as well as critical revisions to 25 of the clinical boxes featured in the previous edition, providing relevant, practical examples of cases commonly encountered in day-to-day practice.
    • Presents new material on T Cell Subsets, the molecular and cellular processes involved in their selection and differentiation, and how this knowledge is already translating into clinical developments.
    • Includes a brand-new chapter titled Regulation of the Immune System.


    ·  Table Of Contents

    ·  I Introduction

    ·  1 Introduction to the Immune System

    ·  2 Basic Concepts and Components of the Immune System

    ·  3 Introduction to Antigen Recognition

    ·  4 Antigens and Antibody Structure

    ·  5 Antibody-Antigen Interaction

    ·  6 Antibody Diversity

    ·  7 The T-Cell Receptor

    ·  8 Major Histocompatibility Complex

    ·  9 Review of Antigen Recognition

    ·  10 Antigen Processing and Presentation

    ·  11 Lymphocyte Activation

    ·  12 Hematopoiesis

    ·  13 Organs and Tissues of the Immune System

    ·  14 B-Cell Development

    ·  15 T-Cell Development

    ·  16 T-Cell Interactions and T-Cell Help

    ·  17 Immunologic Memory and Homeostasis

    ·  18 Regulation of the Immune System

    ·  19 Brief Review of Immune Physiology

    ·  20 Constitutive Defenses Including Complement

    ·  21 Phagocytes

    ·  22 Killing in the Immune System

    ·  23 Inflammation

    ·  24 Cytokines in the Immune System

    ·  25 Infections and Vaccines

    ·  26 Hypersensitivity Reactions

    ·  27 Immediate Hypersensitivity (Type I)

    ·  28 How Autoimmune Disease Develops

    ·  29 Antibody-Mediated Hypersensitivity (Type II)

    ·  30 Immune Complex Disease (Type III Hypersensitivity)

    ·  31 Delayed Hypersensitivity (Type IV) and Review of Hypersensitivity Reactions

    ·  32 Primary Immunodeficiency

    ·  33 Secondary Immunodeficiency

    ·  34 Transplantation

    ·  35 Tumor Immunology

    ·  36 Biopharmaceuticals


  • Manual of Pediatric Allergy
    La comanda in aproximativ 4 saptamani
    215.00 lei


    The new edition of this manual is a practical guide to the diagnosis and management of paediatric allergy.

    Beginning with discussion on the epidemiology and pathophysiology of allergy, the next chapters cover diagnostic techniques.

    The following sections cover the numerous types of allergy including dermatitis, food allergy, ocular allergy and drug allergy. Several chapters are dedicated to asthma.

    The final sections present the advantages and disadvantages of common drugs used for the management of allergy and asthma, selected lab values in allergy and immunology, and devices for treating allergy and asthma.

    The second edition has been fully revised to provide clinicians with the latest advances in the field. Five new topics have been included in this edition – InVitro Testing for Specific IgE, Contact Dermatitis, Clinical importance of Standardisation of Allergens, Rheumatology in Allergy Practice, and Role of Probiotics in Allergic Diseases.

    Key points:

    • Practical guide to diagnosis and treatment of paediatric allergy
    • Fully revised, second edition with new topics added
    • Highly illustrated with clinical photographs and diagrams

    Table of Contents:


    1. Approach to Allergic Child

    2. Sensitization—Epidemiology and Pathophysiology

     3. Diagnosis of Allergic Diseases

    4. In Vitro Testing for Specific IgE

     5. Atopic Dermatitis

    6. Urticaria & Angioedema

     7. Contact Dermatitis

    8. Cow's Milk Allergy

     9. Food Allergy

    10. Anaphylaxis

    11. Ocular Allergies

     12. Clinical Features and Diagnosis of Allergic Rhinitis

     13. Treatment of Allergic Rhinitis

    14. H1 Antihistamines in Paediatric Practice

    15. Genetics of Allergy & Asthm

    a 16. Preschool Asthma

     17. Diagnosis of Asthma

    18. Persistent Bronchial Asthma

    19. Acute Asthma Exacerbations in Childhood

    20. Management of Acute Asthma

    21. Difficult to Treat Asthma

    22. Drug Allergy

    23. Allergens

    24. Clinical Importance of Standardization of Allergens

     25. Environment & Respiratory Allergies

    26. Allergen Specific Immunotherapy

    27. Approach to Primary Immunodeficiency Diseases

    28. Vitamin D and Allergy

    29. Role of Probiotics in Allergic Diseases

    30. Rheumatology in Allergy Practice

    31. Drugs Commonly Used in Allergy & Asthma

    32. Selected Lab Values in Allergy and Immunology

    33. Devices in Allergy and Asthma

  • Immunology: A Short Course
    La comanda in aproximativ 4 saptamani
    240.00 lei

    A Short Course, 7th Edition introduces all the critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely–balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self–contained units that address key topics, illustrated by uniformly drawn, full–color illustrations and photographs. This new edition of Immunology: A Short Course: Has been fully revised and updated, with a brand new art program to help reinforce learning Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area Highlights important therapeutic successes resulting from targeted antibody therapies Includes end of chapter summaries and review questions, a companion website at featuring interactive flashcards, USMLE–style interactive MCQs, figures as PowerPoint slides, and case–based material to help understand clinical applications

  • 25600lei 240.00 lei

    Roitt's Essential Immunology - the textbook of choice for students and instructors of immunology worldwide Roitt s Essential Immunology clearly explains the key principles needed by medical and health sciences students, from the basis of immunity to clinical applications. A brand new introduction sets the scene to section 1, Fundamentals of Immunology, introducing the microbial world and the strategies the body employs to defend itself. Each chapter then guides the reader through a different part of the immune system, and explains the role of each cell or molecule individually, and then as a whole. Section 2, Applied Immunology, discusses what happens when things go wrong, and the role the immune system plays alongside the damaging effects of a disease, including cancer, immunodeficiency, allergies and transplantation and the beneficial effects of vaccines. The 13th edition continues to be a user-friendly and engaging introduction to the workings of the immune system, whilst supporting those who require a slightly more detailed understanding of the key developments in immunology. The content has been fully updated throughout and includes: * An expansion on key clinical topics, including: innate immunity, autoimmune conditions, asthma, primary immunodeficiency, and HIV/AIDS * Beautifully presented with improved artwork and new illustrations * A range of learning features, including introduction re-cap boxes, end of chapter and section summaries to aid revision, as well as further reading suggestions, and a glossary to explain the most important immunology terms. Roitt's Essential Immunology is also supported by a companion website at including: * An additional online only chapter on immunological methods and applications * Further interactive multiple choice and single best answer questions for each chapter * Animations and videos showing key concepts * Fully downloadable figures and illustrations, further reading and useful links * Updated extracts from the Encyclopaedia of Life Sciences * Podcasts to reinforce the key principles explained in the text

  • 27300lei 245.00 lei


    Within this one volume both basic science and clinical immunology are demystified for the medical and other health sciences student. The basic immunological processes are described first, with a level of detail restricted to what is appropriate for medical (and similar) curricula. In the second part of the book, immunological mechanisms behind major diseases of the various body systems are explained. Throughout the text clinical details are highlighted and more in-depth material is differentiated from the main text.


    ·  Preface to the second edition

    ·  Preface to the first edition

    ·  Symbols used in the diagrams

    ·  Table of Contents

    ·  Anatomy and cells of the immune system

    ·  Innate immunity I: physical and humoral protection

    ·  Innate immunity II: cellular mechanisms

    ·  Acquired immunity: antigen receptors

    ·  The human leukocyte antigens

    ·  Cellular immune responses I: dendritic cells, macrophages and B lymphocytes

    ·  Cellular immune responses II: T lymphocytes, antigen presentation and natural killer cells

    ·  The immune response to microbes: an overview

    ·  Tolerance and mechanisms of autoimmunity

    ·  Hypersensitivity reactions and clinical allergy

    ·  Transplantation

    ·  Rheumatic diseases

    ·  Endocrine autoimmune disease

    ·  Liver diseases

    ·  Gastrointestinal diseases

    ·  Immune-mediated nephritis and vasculitis

    ·  Immune-mediated skin disease

    ·  Immune-mediated diseases of the nervous system and eye

    ·  Immunodeficiency

    ·  Human immunodeficiency virus and AIDS

    ·  Immunological manifestations of haematological disease

    ·  Immune-based therapies

    ·  Immunisation

    ·  Appendix

  • Immunohistochemistry: Essential Methods
    La comanda in aproximativ 4 saptamani
    270.00 lei

     Immunohistochemistry and immunocytochemistry are invaluable tools for the visualization of tissue and cellular antigens in diagnostic and biological research environments. The need to obtain accurate, reliable and reproducible results is paramount. It is with this fundamental aim in mind that we have compiled Immunohistochemistry: Essential Methods. We have achieved this by examining each aspect of immunochemistry in turn, with each chapter including detailed information regarding the subject matter in question. Each chapter is written by an expert in their field and includes protocols that are typically used in their own research. Subjects covered are, amongst others, antibodies and their production; selection of reporter labels; immunochemical staining methods and experimental design (both using single and multiple reporter labels); quality assurance; automated immunochemistry; confocal microscopy and electron microscopy. In addition, benefits and limitations of each approach are discussed within the chapters.

  • Allergy in a Nutshell
    La comanda in aproximativ 4 saptamani
    270.00 lei

    This book is a comprehensive guide to the diagnosis and management of allergies. Beginning with an overview of allergy epidemiology, immunology and aerobiology, the next chapters cover different types of allergy - respiratory, gastrointestinal, dermatologic - and include a section on anaphylaxis. The following chapters explain allergy testing techniques as well as supportive investigations such as nasal endoscopy, bronchoscopy and spirometry. The book concludes with discussion on allergy management techniques including complementary medications, and provides appendices detailing algorithmic approaches and pharmacotherapy. Each chapter features explanatory diagrams and tables, international guidelines, and further reading suggestions. Key points Comprehensive guide to diagnosis and management of allergies Examines allergy testing techniques and supportive investigations Includes appendices detailing algorithmic approaches and pharmacotherapy Features numerous diagrams and tables, and further reading suggestions

  • 29400lei 275.00 lei


    Meticulously reviewed and updated for today’s medical students, Basic Immunology, 6th Edition, is a concise text expertly written by the same distinguished author team as the best-selling, comprehensive text, Cellular and Molecular Immunology. This focused, easy-to-understand volume uses full-color illustrations and clinical images, useful tables, and practical features such as Summary Point boxes, end-of-chapter review questions, glossary terms, and clinical cases—all designed to help students master this complex topic in the most efficient, effective manner possible.

    • Emphasizes clinical aspects of immunology, including disease pathogenesis, the development of novel therapies based on basic science, and an appendix of clinical cases for real-world application.
    • Provides top-notch instruction from experienced teachers, course directors, and lecturers led by well-known editor and author Dr. Abul Abbas.
    • Features a highly readable writing style and practical organization, now with fully revised content and updated images to reflect recent important advances in today’s understanding of the immune system.
    • Presents information in a format and style that maximizes usefulness to students and teachers studying medicine, allied health fields, and biology.
    • Contains numerous features designed to help students understand key immunologic concepts: high-quality illustrations, practical tables, chapter outlines, bolded key points, and focus questions in every chapter for self-assessment and review.
    • Evolve Instructor site with a downloadable image bank is available to instructors through their Elsevier sales rep or via request at:



    ·  1. Introduction to the Immune System: Nomenclature, General Properties, and Components

    ·  Innate and Adaptive Immunity

    ·  Types of Adaptive Immunity

    ·  Properties of Adaptive Immune Responses

    ·  Cells of the Adaptive Immune System

    ·  Tissues of the Immune System

    ·  Summary

    ·  2. Innate Immunity: The Early Defense Against Infections

    ·  General Features and Specificity of Innate Immune Responses

    ·  Cellular Receptors for Microbes and Damaged Cells

    ·  Components of Innate Immunity

    ·  Innate Immune Reactions

    ·  Role of Innate Immunity in Stimulating Adaptive Immune Responses

    ·  Summary

    ·  3. Antigen Capture and Presentation to Lymphocytes: What Lymphocytes See

    ·  Antigens Recognized by T Lymphocytes

    ·  Capture of Protein Antigens by Antigen-Presenting Cells

    ·  Structure and Function of Major Histocompatibility Complex Molecules

    ·  Processing and Presentation of Protein Antigens

    ·  Functions of Antigen-Presenting Cells in Addition to Antigen Display

    ·  Antigen Recognition by B Cells and Other Lymphocytes

    ·  Summary

    ·  4. Antigen Recognition in the Adaptive Immune System: Structure of Lymphocyte Antigen Receptors and Development of Immune Repertoires

    ·  Antigen Receptors of Lymphocytes

    ·  Development of B and T Lymphocytes

    ·  Summary

    ·  5. T Cell–Mediated Immunity: Activation of T Lymphocytes

    ·  Phases of T Cell Responses

    ·  Antigen Recognition and Costimulation

    ·  Biochemical Pathways of T Cell Activation

    ·  Functional Responses of T Lymphocytes to Antigen and Costimulation

    ·  Migration of T Lymphocytes in Cell-Mediated Immune Reactions

    ·  Summary

    ·  6. Effector Mechanisms of T Cell–Mediated Immunity: Functions of T Cells in Host Defense

    ·  Types of T Cell–Mediated Immune Reactions

    ·  Development and Functions of CD4+ Effector T Lymphocytes

    ·  Differentiation and Functions of CD8+ Cytotoxic T Lymphocytes

    ·  Resistance of Pathogenic Microbes to Cell-Mediated Immunity

    ·  Summary

    ·  7. Humoral Immune Responses: Activation of B Lymphocytes and Production of Antibodies

    ·  Phases and Types of Humoral Immune Responses

    ·  Stimulation of B Lymphocytes by Antigen

    ·  Functions of Helper T Lymphocytes in Humoral Immune Responses

    ·  Antibody Responses to T-Independent Antigens

    ·  Regulation of Humoral Immune Responses: Antibody Feedback

    ·  Summary

    ·  8. Effector Mechanisms of Humoral Immunity: Elimination of Extracellular Microbes and Toxins

    ·  Properties of Antibodies that Determine Effector Function

    ·  Neutralization of Microbes and Microbial Toxins

    ·  Opsonization and Phagocytosis

    ·  Antibody-Dependent Cellular Cytotoxicity

    ·  Immunoglobulin E– and Eosinophil/Mast Cell–Mediated Reactions

    ·  The Complement System

    ·  Functions of Antibodies at Special Anatomic Sites

    ·  Evasion of Humoral Immunity by Microbes

    ·  Vaccination

    ·  Summary

    ·  9. Immunologic Tolerance and Autoimmunity: Self–Nonself Discrimination in the Immune System and Its Failure

    ·  Immunologic Tolerance: General Priniciples and Significance

    ·  Central T Lymphocyte Tolerance

    ·  Peripheral T Lymphocyte Tolerance

    ·  B Lymphocyte Tolerance

    ·  Tolerance to Commensal Microbes and Fetal Antigens

    ·  Autoimmunity

    ·  Summary

    ·  10. Immunology of Tumors and Transplantation: Immune Responses to Cancer Cells and Normal Foreign Cells

    ·  Immune Responses Against Tumors

    ·  Immune Responses Against Transplants

    ·  Summary

    ·  11. Hypersensitivity: Disorders Caused by Immune Responses

    ·  Types of Hypersensitivity Reactions

    ·  Immediate Hypersensitivity

    ·  Diseases Caused by Antibodies Specific for Cell and Tissue Antigens

    ·  Diseases Caused By Antigen-Antibody Complexes

    ·  Diseases Caused by T Lymphocytes

    ·  Neuroimmunology: Interactions Between the Immune and Nervous Systems

    ·  Summary

    ·  12. Congenital and Acquired Immunodeficiencies: Diseases Caused by Defective Immunity

    ·  Congenital (Primary) Immunodeficiencies

    ·  Acquired (Secondary) Immunodeficiencies

    ·  Acquired Immunodeficiency Syndrome

    ·  Summary

  • 33000lei 280.00 lei

    Mount Sinai Expert Guides: Allergy and Clinical Immunology will provide trainees in allergy and immunology with an extremely clinical and accessible handbook covering the major disorders and symptoms, their diagnosis and clinical management. Perfect as a point-of-care resource on the hospital wards and also as a refresher for board exam preparation, the focus throughout is on providing rapid reference, essential information on each disorder to allow for quick, easy browsing and assimilation of the must-know information. All chapters follow a consistent template including the following features: · An opening bottom-line/key points section · Classification, pathogenesis and prevention of disorder · Evidence-based diagnosis, including relevant algorithms, laboratory and imaging tests, and potential pitfalls when diagnosing a patient · Disease management including commonly used medications with dosages, management algorithms and how to prevent complications · How to manage special populations, ie, in pregnancy, children and the elderly · The very latest evidence-based results, major society guidelines and key external sources to consult In addition, the book comes with a companion website housing extra features such as case studies with related questions for self-assessment, key patient advice and ICD codes. Each guide also has its own mobile app available for purchase, allowing you rapid access to the key features wherever you may be. If you're specialising in allergy and immunology and require concise, practical and clinical guidance from one of the world's leading institutions in this field, then this is the perfect book for you.

  • 37400lei 300.00 lei



    Covering all the basic and clinical concepts you need to know for your coursework and USMLEs, Immunology, 9th Edition, offers a well-illustrated, carefully structured approach to this complex and fast-changing field. Carefully edited and authored by experts in both teaching and research, it provides cutting-edge, consistent coverage that links the laboratory and clinical practice. A user-friendly, color-coded format, including key concept boxes, explanatory diagrams, and nearly 200 photos to help you visually grasp and retain challenging concepts.


    Explains the building blocks of the immune system - cells, organs, and major receptor molecules - as well as initiation and actions of the immune response, especially in a clinical context.

    Features a reorganized format that presents immunology in the order in which is typically taught and learned, better integrating basic and clinical immunology.

    Provides Critical Thinking boxes, chapter-opening summaries, and case-based and USMLE-style questions that provide effective review and quick practice for exams - plus more learning opportunities online, including USMLE-style questions and clinical cases.

    New To This Edition:

    Includes extensive updates to clinical information, including recent clinical approaches in cancer immunology, transplantation, autoimmunity, hypersensitivity, and more.

    Covers new topics such as innate lymphoid cells, antibody-based therapies and antibody engineering, innate immunity and its components, the genetics of immunologically-based diseases and personalized medicine, and immunotherapeutic agents for the treatment of cancer.


    Table Of Contents:



    SECTION 1 The Immune System and Innate Immunity

    1 Introduction to the Immune System

    2 Cells, Tissues and Organs of the Immune System

    3 Mechanisms of Innate Immunity

    4 Complement

    5 Mononuclear Phagocytes in Immune Defence

    SECTION 2 Adaptive Immune Responses

    6 T-Cell Receptors and Major Histocompatibility Complex Molecules

    7 Antigen Presentation

    8 Cell-Mediated Cytotoxicity

    9 B-Cell Development and the Antibody Response

    10 Antibodies

    11 Immunological Tolerance

    12 Regulation of the Immune Response

    13 Immune Responses in Tissues

    SECTION 3 Defence Against Infectious Agents

    14 Immunity to Viruses

    15 Immunity to Bacteria and Fungi

    16 Immunity to Protozoa and Worms

    17 Vaccination

    SECTION 4 Immunodeficiency

    18 Primary Immunodeficiencies

    19 AIDS, Secondary Immunodeficiency and Immunosuppression

    SECTION 5 Immune Responses Against Tissues

    20 Autoimmunity and Autoimmune Disease

    21 Transplantation and Rejection

    22 Immunity to Cancers

    SECTION 6 Hypersensitivity

    23 Immediate Hypersensitivity (Type I)

    24 Hypersensitivity (Type II)

    25 Hypersensitivity (Type III)

    26 Hypersensitivity (Type IV)



  • 37000lei 325.00 lei

    The top required and recommended immunology text worldwide, Cellular and Molecular Immunology by Drs. Abul K. Abbas, Andrew H. H. Lichtman, and Shiv Pillai, is a clear, well-written, and superbly illustrated introduction to the field. The 9th Edition retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout. Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program. Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions. Includes summary boxes that assist with rapid review and mastery of key material. Student ConsultT digital version  included with purchase. This enhanced digital version experience allows you to search all of the text, figures, references and animations, designed to produce a more rounded learning experience. Features updates from cover to cover, including tumor immunity (tumor antigens, cancer immunotherapy), immune checkpoints, cytosolic sensors for DNA, non-canonical inflammasomes, prionization as a signaling mechanism, monogenic defects in immunity, and more.

  • Transplant Immunology
    La comanda in aproximativ 4 saptamani
    35400lei 335.00 lei

    With all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area. Produced in association with the American Society of Transplantation, and written by experts within the field, Transplant Immunology provides a comprehensive overview of the topic in relation to clinical transplantation. Starting with the basic functionality of the immune system, it then moves on to cover the very latest developments in immunosuppressive drugs and protocols, as well as a look at all emerging technologies in the field.

  • 37800lei 340.00 lei



    Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. It’s an ideal resource for medical, graduate, and undergraduate students, as well as a trusted reference for physicians and scientists.  



    Table Of Contents:


    Chapter1 Properties and Overview of Immune Responses

    Chapter2 Cells and Tissues of the Immune System

    Chapter3 Leukocyte Circulation and Migration into Tissues

    Chapter4 Innate Immunity

    Chapter5 Antibodies and Antigens

    Chapter6 Antigen Presentation to T Lymphocytes and the Functions of MHC Molecules

    Chapter7 Immune Receptors and Signal Transduction

    Chapter8 Lymphocyte Development and Antigen Receptor Gene Rearrangement

    Chapter9 Activation of T Lymphocytes

    Chapter 10 Differentiation and Functions of CD4+ Effector T Cells

    Chapter 11 Differentiation and Functions of CD8+ Effector T Cells

    Chapter 12 B Cell Activation and Antibody Production

    Chapter 13 Effector Mechanisms of Humoral Immunity

    Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues

    Chapter 15 Immunologic Tolerance and Autoimmunity

    Chapter 16 Immunity to Microbes

    Chapter 17 Transplantation Immunology

    Chapter 18 Immunity to Tumors

    Chapter 19 Hypersensitivity Disorders

    Chapter 20 Allergy

    Chapter 21 Congenital and Acquired Immunodeficiencies

    Appendix I Glossary

    Appendix II Cytokines

    Appendix III Principle Features of Selected CD Molecules

    Appendix IV Laboratory Techniques Commonly Used in Immunology


    Bottom of Form


  • Middleton's Allergy Essentials
    La comanda in aproximativ 4 saptamani
    52500lei 420.00 lei

    For decades, health care practitioners have relied on Middleton's Allergy as their go-to reference for comprehensive information on allergic disorders. Now Middleton's Allergy Essentials, by Drs. Robyn E. O'Hehir, Stephen T. Holgate, and Aziz Sheikh, offers a concise resource that's both easily accessible and highly authoritative. Perfect for clinicians in primary and secondary care settings, this practical volume covers what is most useful in your daily practice, with a strong emphasis on disease diagnosis and management.

  • 50600lei 440.00 lei

    This third edition of the essential guide has been extensively revised and updated and includes additional color illustrations. It reflects the rapid expansion in knowledge of the subject due to progress in the chemical, immunological, and clinical fields.

  • 54700lei 460.00 lei



    With complete, concise coverage of prevention, indications, diagnosis, and treatment, Pediatric Allergy, 4th Edition, is your go-to resource for current, clinically-focused content in the rapidly changing field of allergies and immune-mediated diseases in children. This highly regarded reference fully covers immunology and origins of allergy, growth and development, pregnancy, infancy, and early, middle, and late childhood-all with a new, practical, clinical focus. You’ll find authoritative coverage of the full range of allergies in pediatric patients, from asthma and other common conditions to rare or uncommon allergies, providing a one-stop resource for clinicians across specialties who care for children.


    Key Features:


    • Focuses on the clinical application of science to the bedside, including clinical pearls discussing best practice approaches and guidelines. 
    • Integrates the latest research on the origins of allergy in early life, including pregnancy, the neonate, and infants.
    • Includes new, evidence-based management guidelines for various diseases, including food allergy, atopic dermatitis, asthma and immunodeficiency.
    • Provides new content on the prevention of allergies; asthma, eczema, and food allergies in young children; and extensive current guidelines and new therapies.
    • Offers up-to-date information on key areas such as food challenges, skin testing, IgE diagnostic labs, immunotherapy, clinical immunology diagnostic testing, molecular diagnostics, and lung function testing.
    • Highlights current guidance from a new team of leading experts with 150 anatomic schematics, clinical photos, and algorithms—many new to this edition.
    • Covers gene therapy, stem-cell therapy, and a host of immunodeficiency diseases found in children with allergies.
    • Discusses targeted biologics for severe allergic diseases, defects of innate immunity, rheumatic diseases of childhood, and inflammatory disorders.

    Enhanced version included with purchase. Your enhanced allows you to access all of the text, figures, and references from the book on a variety of devices.

  • Patterson's Allergic Diseases
    La comanda in aproximativ 4 saptamani
    51400lei 490.00 lei


    Since 1972, Patterson’s Allergic Diseases has been the go-to reference for healthcare practitioners looking for a comprehensive and practical guide to the diagnosis and treatment of allergic disorders. This eighth edition focuses on patient evaluation and management, and covers immunologic mechanisms, pathophysiology, pharmacology, and diagnostic techniques. Many contributors hail from outside the field of allergy-immunology, providing an invaluable non-specialist perspective on essential clinical practices.

    Table of Contents:

    SECTION I The Immune System: Biologic and Clinical Aspects

    1 Review of Immunology

    2 Immunology of IgE-Mediated and Other Hypersensitivity Responses

    3 Biochemical Mediators of Allergic Reactions

    4 Evaluation and Management of Immune Deficiency in Allergy Practice

    5 Evaluation of Eosinophilia

    SECTION II Pathogenic and Environmental Aspects in Allergy and Asthma

    6 Allergens and Other Factors Important in Atopic Disease

    7 Airborne Pollen Prevalence in the United States

    SECTION III Principles of Evaluation and Treatment

    8 Diagnosis of Immediate Hypersensitivity

    9 Physiologic and Biologic Evaluation of Allergic Lung Diseases

    10 Radiologic Evaluation of Allergic and Related Diseases of the Upper Airway

    11 Radiologic Evaluation of Allergic and Related Diseases of the Lower Airway

    12 Chronic Rhinosinusitis: Role of Rhinoscopy and Surgery

    13 Principles of Immunologic Management of Allergic Diseases Due to Extrinsic Antigens

    SECTION IV Anaphylaxis and Other Generalized Hypersensitivity

    14 Anaphylaxis

    15 Allergy to Stinging Insects

    16 Erythema Multiforme, Stevens–Johnson Syndrome, and Toxic Epidermal Necrolysis

    17 Drug Allergy

    Part A Introduction, Epidemiology, Classification of Adverse Reactions, Immunochemical Basis, Risk Factors, Evaluation of Suspected Drug Allergy, and Patient Management Considerations

    Part B Allergic Reactions to Individual Drugs: Low-Molecular-Weight

    Part C Immunologic Reactions to High-Molecular-Weight Therapeutic Agents

    18 Food Allergies

    SECTION V Asthma

    19 Asthma

    20 The Infant and Toddler with Asthma

    21 Acute Severe Asthma

    22 Asthma Clinical Trials

    SECTION VI Other Immunologic Pulmonary Diseases

    23 Hypersensitivity Pneumonitis

    24 Allergic Bronchopulmonary Aspergillosis

    25 Occupational Immunologic Lung Disease and Occupational Rhinitis

    SECTION VII Upper Respiratory Tract Diseases

    26 Allergic Rhinitis

    27 Nasal Polyposis, Rhinosinusitis, and Nonallergic Rhinitis

    28 Allergic Diseases of the Eye and Ear

    SECTION VIII Cutaneous Allergic Diseases

    29 Atopic Dermatitis

    30 Contact Dermatitis

    31 Urticaria, Angioedema, and Hereditary Angioedema

    32 Approach to the Patient with Pruritus

    SECTION IX Pharmacology

    33 Antihistamines

    34 β Agonists

    35 Corticosteroids in Treatment of Allergic Diseases

    36 Other Antiallergic Drugs: Cromolyn, Nedocromil, Antileukotrienes, Anticholinergics, and Theophylline

    37 Delivery Devices for Inhaled Medications

    38 Novel Immunologic Therapies, Including Biologics

    SECTION X Special Situations

    39 Allergic Disorders in Pregnancy

    40 Eosinophilic Esophagitis

    41 Chronic Cough

    42 Sleep Disorders in the Allergic Patient

    43 Management of the Psychologically Complicated Patient

    44 In Vivo and In Vitro Testing in Allergy and Immunology

    45 Controversial and Unproved Methods in Allergy Diagnosis and Treatment

    46 Personalized Medicine in Allergy-Immunology



  • 63500lei 580.00 lei

    Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees.
      • The third edition of the Manual of Diagnostic Antibodies for Immunohistology, fully updated with over forty new entries, outlining the specificities of monoclonal and antisera antibodies and their key uses
      • Highlights caveats and how to avoid the most common problems in practical application of immunohistochemistry
      • Each entry follows a standard structure for quick and easy access and retrieval of information

  • 66500lei 640.00 lei

     When a biological drug patent expires, alternative biosimilar products are developed. The development of biosimilar products is complicated and involves numerous considerations and steps. The assessment of biosimilarity and interchangeability is also complicated and difficult.Biosimilar Drug Product Development presents current issues for the development of biosimilars and gives detailed reviews of its various stages and contributing factors as well as relevant regulatory pathways and pre- and post-approval issues.

  • 675.00 lei

    This book is a quick guide for clinicians, specialists, and residents. It provides a concise overview of the practical aspects of contact dermatitis, supplying the tools to allow a fast and reliable diagnosis. The book describes the clinical features of contact dermatitis, explains how to make an exposure assessment and covers other essentials in the diagnostic work. Information is presented on testing with patients’ own products and overviews are provided on the allergens contained in various products. In addition, a helpful list of the most frequent allergens is included. The authors are leading practitioners in the field, and their expertise has enabled the compilation of an approachable text supplemented by a large number of full color illustrations, tables and check lists. This book will help the reader to gain a better understanding of the subject and to achieve greater competence in everyday practice.

  • 73000lei 700.00 lei

    This volume opens by providing a comprehensive overview of the use and regulation of metals in our society, metal properties, and available testing methodologies. Common and uncommon metal allergens and sources of exposure are then reviewed in depth, detailing allergic responses and paying special consideration to select patient populations. In the general population, the prevalence of metal allergy is high. Environmental sources of metal exposure include jewelry, clothing, electronic devices, coins, leather, diet, and occupational exposure. Metal allergy may result in allergic contact dermatitis and systemic contact dermatitis, as well as several less common manifestations. Further, metal allergy has been associated with device failure and/or dermatitis following implantation of medical devices and dental implants. As metals are ubiquitous, this book will be indispensable for a wide range of clinicians and investigators. This handy reference will meet the needs of all health professionals and investigators who are interested in metal allergy and its diagnosis and management.

  • 88200lei 735.00 lei

    For more than 50 years, Dubois' Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It's an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. Offers an increased focus on the clinical management of related disorders such as Sjogren's syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout. Expert ConsultT version included with purchase. This enhanced experience allows you to search all of the text, figures, and references from the book on a variety of devices.

  • 89800lei 750.00 lei

    This volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes – such as oncogenes, proto-oncogenes, or tumor suppressor genes – in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading scientists in their respective fields, the volume offers a valuable resource for researchers and clinicians alike.

  • 760.00 lei

    This book explores the recent advances and integrations in molecular technology in food research platforms, which have revolutionized the way we discover and trace potential allergens in our food and drugs and how we utilize that for diagnosis and management. These different technologies for global allergenomic profiling in different kinds of food are discussed, including mass spectrometry, chromatography, and nuclear magnetic resonance. The book also addresses multiomics research with bioinformatics strategies in food allergy in terms of allergen characterization and quantitation, and covers applications in food allergy research from discovery to routine analysis.

  • 786.00 lei

    The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified. It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice. This response is complex and includes effector functions that mediate resistance, contributing to expulsion and in some cases destruction, of the parasite. But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs. The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis. In this book, leading researchers in this exciting and dynamic field discuss the latest findings and emerging concepts, providing an intellectual framework that can be used as a basis for new discoveries and potentially new treatments for diseases associated with inflammation.

  • 95500lei 805.00 lei

    Allergy is developing into one of the most prevalent diseases affecting individuals in the very early days of life. While the cause of this epidemic is still unclear, it appears that the westernized life style is playing an important role, which includes nutrition, possibly air pollution as well as hygienic conditions. While epidemiologic studies were able to narrow down these factors, basic research discovered novel mechanisms that control the organism´s tolerance against allergens. Particularly interesting is the role of microorganisms that colonize or infect a host and thereby cause damage and immunological activation followed by sensitization or exacerbation of already existing sensitizations. However at the same time microbial activation of the immune system can help to generate a protective immunity that prevents allergen sensitization. The current book is collecting these evidences and connects epidemiologic and clinical mechanistic knowledge. Only the synthesis of this knowledge will help to find solutions to the ongoing allergy epidemic in terms of public health activities, prevention and therapy.

  • 840.00 lei

    The book introduces the bioinformatics resources and tools available for the study of allergenicity. Allergy symptoms affect more than 25% of the population in industrialized countries. At the same time, biotechnology is a rapidly developing field, which often involves the introduction of potentially allergenic novel proteins into drugs or foods. It is essential to avoid transferring a gene that encodes a major allergenic protein (from any source) into a drug/food crop that did not previously contain that protein. Accurately distinguishing candidate genes from allergens before transferring them into a drug or food would aid preventive efforts to curb the rising incidence of allergies. Several public databases have been created in response to increasing allergen data. The resources provided by these databases have paved the way for the creation of specialized bioinformatics tools that allow allergenicity to be predicted. The book is a useful resource for biologists and biomedical informatics scientists, as well as clinicians. Dr. Ailin Tao is the chief of Guangdong Province Key Laboratory of Allergy & Clinical Immunology, Principal Investigator of the State Key Laboratory of Respiratory Disease, the Second Affiliated Hospital of Guangzhou Medical University; Dr. Prof. Eyal Raz is a Professor of Medicine at University of California, San Diego, La Jolla, California, USA.

  • 840.00 lei

    To celebrate the 40th anniversary of the discovery of Natural Killer (NK) cells, this volume focuses on the recent advances in our understanding of NK cell development and differentiation and their acquisition of functional properties, as well as the latest models for NK-cell analysis in mice and applications in clinical medicine. NK cells have travelled a circuitous path from their initial description as ‘spontaneous killers’ (for some simply an experimental artifact) to being a bona fide subset of innate lymphoid cells with a complementary mode of action in immune defense and an important mediator of immune reactivity in health and disease. Together, these reviews provide a timely and concise picture of the evolution of NK cells as essential agents in immunity and as potent weapons against disease. This book offers an appealing and insightful resource for scientists and clinicians.

  • 1,01100lei 870.00 lei

    This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. This leap in assay sensitivity and specificity has led to three major advances in patient management: discrimination between primary allergic sensitization and complex cross-reactivity, recognition of IgE profiles for certain allergens and identification of patients most likely to benefit from allergen-specific immunotherapy. The book discusses in detail the benefits and limitations of this 21st century technology, and offers suggestions for the use of molecular allergology in routine clinical practice. It is a “must read” for physicians treating allergic patients as well as scientists interested in natural allergic molecules and their interactions with the human immune system.

  • 1000.00 lei

    This highly practical, easy-to-read, fully updated and expanded resource offers a wide range of targeted guidelines and insights in allergy medicine. Written by a leading allergy clinician -- along with a renowned group of nationally recognized expert contributors in allergy and immunology, pulmonary, and infectious diseases -- this title is a proven resource for front-line general practitioners, especially primary care physicians. The most clinically relevant information is provided on the pathophysiology, diagnosis, treatment, and prevention of all major allergic disorders. Each chapter has a section on “Evidence-Based Medicine” that introduces one to two recent research publications on the subject, and several chapters have been written by new authors. Covering the entire scope of adult and pediatric allergy and asthma and organized by specific organ which guides the reader to diagnostic and therapeutic solutions quickly and easily, the book offers a wealth of outstanding illustrations, key concepts, management protocols, and updated references. An invaluable contribution to the field, Allergy and Asthma: Practical Diagnosis and Management, 2nd Edition will be of immense value not only to primary care physicians, but also to fellows in training, residents, nurses, nurse practitioners, and medical and allied health students.

  • 1,23600lei 1100.00 lei

    The number of diagnosed cases of primary immunodeficiency diseases (PIDs) – a group of inborn disorders of the immune system – is growing rapidly, but misdiagnosis or late diagnosis still occurs in a significant number of patients, with serious consequences. This is the second edition of a practical reference textbook on PIDs that has been widely welcomed by scientists and clinicians from around the world.

          The new edition has been extensively revised to reflect advances in knowledge and includes various PIDs not previously covered. For each disease, information is provided on definition, etiology, clinical manifestations, diagnosis, and management. This book will represent an ideal resource for specialists when engaging in diagnosis, clinical decision-making, and treatment planning. It will also prove invaluable for doctors in training and other physicians and nurses who wish to learn more about PIDs.

    Table of contents (10 chapters)


    ·         Introduction on Primary Immunodeficiency Diseases

    Rezaei, Nima (et al.)

    Pages 1-81

    ·         Combined T- and B-Cell Immunodeficiencies

    Deist, Françoise (et al.)

    Pages 83-182

    ·         Predominantly Antibody Deficiencies

    Aghamohammadi, Asghar (et al.)

    Pages 183-244

    ·         Phagocytes Defects

    Wintergerst, Uwe (et al.)

    Pages 245-294

    ·         Genetic Disorders of Immune Regulation

    Speckmann, Carsten (et al.)

    Pages 295-338

    ·         Defects in Intrinsic and Innate Immunity: Receptors and Signaling Components

    Parvaneh, Nima (et al.)

    Pages 339-392

    ·         Autoinflammatory Disorders

    Berg, Stefan (et al.)

    Pages 393-435

    ·         Complement Deficiencies

    Mahmoudi, Maryam (et al.)

    Pages 437-460

    ·         Other Well-Defined Immunodeficiencies

    Gennery, Andrew R. (et al.)

    Pages 461-517

    ·         Syndromic Immunodeficiencies

    Ming, Jeffrey E. (et al.)

    Pages 519-551

  • 1,42300lei 1140.00 lei

    Keep abreast of the latest advances in this complex field with the 5th Edition of Clinical Immunology: Principles and Practice. This substantially revised edition by Drs. Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder, Jr., Anthony J. Frew, and Cornelia M. Weyand, offers authoritative guidance from some of the most respected global leaders in immunology, helping you navigate today’s latest knowledge and evidence-based practices that result in improved patient care. This trusted resource features sweeping content updates, rewritten chapters, a highly clinical perspective, and an easy-to-use organization designed to enhance your diagnosis and management skills in daily practice.
    User-friendly format features color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles.

    New To This Edition:

    •    Includes new chapters on the Microbiota in Immunity and Inflammation, Immune Responses to Fungi, and Genetics and Genomics of Immune Response.
    •    Features extensive revisions to many chapters, including the Major Histocompatibility Complex, Multiple Sclerosis, Diabetes and Related Autoimmune Diseases, Biologic Modifiers of Inflammation and Tumor Immunotherapy.
    •    Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics.
    •    Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more.
    •    Summarizes promising research and development anticipated over the next 5-10 years with "On the Horizon" boxes and discussion of translational research.
    •    Includes new multiple choice questions in every chapter online, ideal for allergists and rheumatologists seeking certification or recertification in these subspecialties.
    •    Expert Consult™ digital version included with purchase. This enhanced digital experience allows you to search all of the text, figures, and references from the book on a variety of devices.

  • 1180.00 lei

    Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency. The most comprehensive text on mucosal immunology from internationally recognized experts in the field Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases Contains nine new chapters and an expanded appendix

  • Laboratory Models for Foodborne Infections
    La comanda in aproximativ 4 saptamani
    1,24000lei 1220.00 lei

     Resulting from ingestion of inappropriately prepared or stored foods containing pathogenic viruses, bacteria, fungi and parasites, foodborne infections have become a significant source of human morbidity and mortality worldwide in recent decades. This may be largely attributable to the remarkable popularity of convenient, ready-to-eat food products, the dramatic expansion of international food trades, and the continuing growth of immuno-suppressed population groups. Although anti-microbial treatments have played a crucial part in the control of foodborne infections in the past, the emergence and spread of anti-microbial resistance render the existing treatments ineffective. Additionally, our limited understanding of the molecular mechanisms of foodborne infections has thwarted our efforts in the development of efficacious vaccines for foodborne pathogens. 

    Given the obvious benefits of laboratory models in foodborne disease research, a great number of experiments have been conducted toward the elucidation of host-pathogen interactions in and pathogenic mechanisms of foodborne infections. Forming part of the Food Microbiology series, Laboratory Models for Foodborne Infections presents a state-of-the-art review of laboratory models that have proven valuable in deciphering the life cycle, epidemiology, immunobiology, and other key aspects of foodborne pathogens. 

    Written by scientists with respective expertise in foodborne pathogen research, each chapter includes a contemporary summary of a particular foodborne viral, bacterial, fungal, or parasitic infection in relation to its life cycle, epidemiology, clinical features, pathogenesis, host-pathogen interactions, and other related aspects. Besides providing a trustworthy source of information for undergraduates and postgraduates in food microbiology, Laboratory Models for Foodborne Infections offers an invaluable guide for scientists and food microbiologists with interest in exploiting laboratory models for detailed study of foodborne infections.

  • 1,29200lei 1230.00 lei

    The Atlas of Sexually Transmitted Diseases and Differential Diagnosis is a complete course through the most important sexual diseases. Counting with about 1000 figures, this atlas focuses on the peculiar characteristics of each of these diseases and in the relevant aspects for a proper differential diagnosis. It is authored by MDs with a deep knowledge in the field, providing a very comprehensive casuistry. Throughout the book the reader will have access to hundreds of pictures discussing about the most important sexually transmitted diseases. Each chapter will approach a different disease, providing a broad sort of images, since a microscopic perspective until the most classical genital lesions and characteristics, considering also systemic manifestations. Every figure is presented with a descriptive and instructive legend, providing the reader with all possible related information. Additionally, every chapter begins with an explanatory and introductory text disclosing about key aspects of the disease, such as etiopathogenesis; clinical manifestation; clinical, laboratorial and differential diagnosis; treatment and prevention.

  • Middleton s Allergy 2-Volume Set, 9th Edition
    La comanda in aproximativ 4 saptamani
    1,54400lei 1300.00 lei

    Through eight outstanding editions, Middleton’s Allergy: Principles and Practice has been the reference of choice for both clinicians and researchers as both a practical reference and an effective self-assessment tool for board preparation. The 9th Edition continues the tradition of excellence with comprehensive coverage of all basic science and clinical applications regarding allergy practice and disease mechanisms. It brings you fully up to date with recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies.

    Table Of Contents:

    Volume 1
    SECTION A Basic Sciences Underlying Allergy and Immunology

    1 Innate Immunity
    2 Adaptive Immunity
    3 Immunoglobulin Structure and Function
    4 Immune Tolerance
    5 Cytokines in Allergic Inflammation
    6 Cellular Adhesion in Inflammation
    7 Chemokines
    8 The Complement System
    9 Lipid Mediators of Hypersensitivity and Inflammation
    10 Molecular Biology and Genetic Engineering
    11 Biology of Lymphocytes
    12 Innate Lymphoid Cells
    13 Antigen-Presenting Dendritic Cells
    14 Biology of Mast Cells and Their Mediators
    15 Biology of Basophils
    16 Biology of Eosinophils
    17 Biology of Neutrophils
    18 Biology of Monocytes and Macrophages
    19 Airway Epithelial Cells
    20 Airway Smooth Muscle
    21 Pathophysiology of Allergic Inflammation
    22 Genetics and Epigenetics in Allergic Diseases and Asthma
    23 Systems Biology
    24 Immunobiology of IgE and Its Receptors
    25 Neuronal Control of Airway Function in Allergy
    SECTION B Aerobiology and Allergens
    26 The Structure and Function of Allergens
    27 Aerobiology of Outdoor Allergens
    28 Indoor Allergens
    29 Preparation and Standardization of Allergen Extracts
    30 Air Pollution: Indoor and Outdoor
    31 Effect of the Food Matrix and Processing on the Allergenic Activity of Foods
    SECTION C The Skin

    32 Structure of the Skin and Cutaneous Immunology
    33 Atopic Dermatitis
    34 Contact Dermatitis
    35 Urticaria and Angioedema
    36 Hereditary Angioedema and Bradykinin-Mediated Angioedema
    37 Immune Complex Mediated Diseases
    SECTION D The Eye
    38 Allergic and Immunologic Diseases of the Eye
    SECTION E Respiratory Tract
    39 The Nose and Control of Nasal Airflow
    40 Allergic and Nonallergic Rhinitis
    41 Rhinosinusitis and Nasal Polyps
    42 Development, Structure Lung and in Asthma
    43 Respiratory Tract Mucosal Immunology
    44 Airway Mucus and the Mucociliary System
    45 Epidemiology of Asthma and Allergic Diseases
    46 Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma
    47 Asthma Pathogenesis
    48 Animal Models of Allergic Disease
    49 Diagnosis of Asthma in Infants and Children
    50 Management of Asthma in Infants and Children
    51 Diagnosis of Asthma in Adults
    52 Management of Asthma in Adolescents and Adults
    53 Emergency Treatment and Approach to the Patient with Acute Asthma
    54 Approach to the Patient with Exercise-Induced Bronchoconstriction
    55 Asthma and Allergic Diseases during Pregnancy
    56 Occupational Allergy and Asthma
    57 Pathology of Asthma
    58 Allergic Bronchopulmonary Aspergillosis Hypersensitivity Pneumonitis and Epidemic Thunderstorm Asthma
    59 Immunologic Nonasthmatic Diseases of the Lung
    60 Approach to the Patient with Chronic Cough
    61 Bronchial and Nasal Challenge Testing
    62 Lung Imaging
    63 Aerosols and Aerosol Drug Delivery Systems
    VOLUME 2
    SECTION F Gastrointestinal Tract
    64 Gastrointestinal Mucosal Immunology
    65 Eosinophilic Gastroenteropathies Disorders
    SECTION G Systemic Disease
    66 Clinical Significance of Immunoglobulin E
    67 In Vivo Methods for the Study and Diagnosis of Allergy
    68 Approach to the Patient with Recurrent Infections
    69 Primary Immunodeficiency Diseases
    70 Treatment of Primary Immunodeficiencies
    71 Human Immunodeficiency Virus and Allergic Disease
    72 Laboratory Tests for Allergic and Immunodeficiency Diseases
    73 Eosinophilia and Eosinophil-Related Disorders
    74 Mastocytosis
    75 Anaphylaxis
    76 Insect Allergy
    77 Drug Allergy
    78 Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs
    79 Reactions to Foods
    80 Reactions to Additives in Foods in Drugs
    81 Oral Food Challenge Testing
    82 Food Allergy Management
    83 Adverse Reactions to Vaccines
    SECTION H Therapeutics
    84 Allergen Control for Prevention and Management of Allergic Diseases
    85 Injection Immunotherapy for Inhalant Allergens
    86 Sublingual Immunotherapy for Inhalant Allergens
    87 Principles of Pharmacotherapeutics
    88 Precision Medicine in Allergic Disorders
    89 Adherence
    90 Anti-Immunoglobulin E Therapy
    91 Cytokine-Specific Therapy in Asthma
    92 Histamine and Antihistamines
    93 Inhaled ß2-Agonists
    94 Theophylline and Phosphodiesterase Inhibitors
    95 Anticholinergic Therapies
    96 Glucocorticosteroids
    97 Antileukotriene Therapy in Asthma
    98 Unconventional Theories and Unproven Methods in Allergy
    99 Complementary and Alternative Medicine

  • 2,13100lei 1740.00 lei



    Thoroughly revised and updated, the 7th Edition of Rheumatology remains a leading text in this fast-changing field, keeping you abreast of recent advances in medications, therapies, clinical trials, and much more. Dr. Mark Hochberg and his team of expert authors and editors cover everything you need to know -- from basic scientific principles to practical clinical management strategies, all in a user-friendly, accessible manner.


    Provides access to quick, concise videos depicting musculoskeletal ultrasound including anisotropy, "comet tail" needle artifact, rheumatoid arthritis synovitis, acute gout, and more.

    Uses a consistent, logical, reader-friendly format with templated content and large-scale images for efficient visual reference.

    New To This Edition:

    Features 14 completely new chapters covering biomedical and translational science, disease and outcome assessment, including new imaging modalities and early emerging disease, clinical therapeutics, and patient management and rehabilitation.

    Includes updated content on the latest diagnostic perspectives and approaches to therapy including tapering down of treatment, pulmonary hypertension and scleroderma, psoriatic arthritis, and the latest oral anticoagulants.

    Covers hot topics such as pathogenesis and pathophysiology of axial spondyloarthritis, DXA and measurement of bone, infectious arthritis, and more.

    Shares the knowledge and expertise of internationally recognized rheumatoid arthritis expert and new editor, Dr. Ellen Gravallese.

    Expert Consult™ digital version included with purchase. This enhanced digital experience allows you to search all of the text, figures, and references from the book on a variety of devices.