Best Practices of Apheresis in Hematopoietic Cell Transplantation (Advances and Controversies in Hematopoietic Transplantation and Cell Therapy)

About this book

In this book, world-renowned experts in the field of hematopoietic cell transplantation examine a range of issues and controversies relating to apheresis, with the aim of identifying current trends and best practices. Readers will find up-to-date guidance on donor evaluation, CD34+ cell mobilization strategies, options and selection of apheresis device, anticoagulation techniques in apheresis, the role of prediction algorithms in determining procedure eligibility and length, and the prevention and management of complications.

Applications of apheresis devices in the processing of bone marrow grafts are discussed, and detailed attention is devoted to the indications and rationale for therapeutic apheresis procedures, with individual chapters focusing on therapeutic plasma exchange and immunoadsorption, red cell exchange, and extracorporeal photopheresis. Finally, the applications of apheresis in pediatric donors and in resource-limiting environments are considered. This book, featuring numerous helpful tables, algorithms, and figures, will be of high practical value for residents, fellows, faculty members and other healthcare personnel involved in hematopoietic cell transplantation.

Table of contents (15 chapters)

Introduction and Rationale

Pages 1-3

Padmanabhan, Anand (et al.)

Administrative and Regulatory Considerations for Apheresis Collection Facilities

Pages 5-10

Schwartz, Joseph (Yossi) (et al.)

FACT-JACIE Standards: Common Citations and How Best to Avoid Them

Pages 11-21

Gastineau, Dennis A. (et al.)

Donor Evaluation for Hematopoietic Stem and Progenitor Cell Collection

Pages 23-49

Connelly-Smith, Laura S.

Mobilization Strategies: HPC(A) Collections for Autologous Hematopoietic Cell Transplants

Pages 51-62

Worel, Nina

Mobilization Strategies: HPC(A) Collections for Allogeneic Hematopoietic Cell Transplants

Pages 63-80

Bhamidipati, Pavan Kumar (et al.)

Hematopoietic Progenitor Cells, Apheresis and Therapeutic Cells, T-Cells Collection: Instrumentation, Operating Parameters, and Troubleshooting

Pages 81-100

Burgstaler, Edwin A. (et al.)

Anticoagulation and Other Periprocedural Considerations for Apheresis

Pages 101-107

Karafin, Matthew S. (et al.)

Concepts and Rationale for Using Predictive Algorithms for Hematopoietic Progenitor Cell Apheresis Collection

Pages 109-119

Cottler-Fox, Michele

Applications of Apheresis Devices in Processing Bone Marrow Grafts

Pages 121-134

Leitner, Gerda C.

Therapeutic Plasma Exchange and Immunoadsorption: Indications and Implementation

Pages 135-150

Handisurya, Ammon (et al.)

Red Blood Cell Exchange: When and Why?

Pages 151-160

Stussi, Georg (et al.)

Extracorporeal Photopheresis in Hematopoietic Cell Transplantation

Pages 161-186

Hölig, Kristina (et al.)

Prevention and Management of Apheresis Complications

Pages 187-200

Neyrinck, Marleen M. (et al.)

Challenges and Optimization of Apheresis Procedures in Resource-Limiting Environments

Pages 201-211

Koh, Mickey B. C. (et al.)