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  • 59400lei 505.00 lei

    Make sure you are thoroughly prepared to work in a clinical lab. Rodak's Hematology: Clinical Principles and Applications, 6th Edition uses hundreds of full-color photomicrographs to help you understand the essentials of hematology. This new edition shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. Easy to follow and understand, this book also covers key topics including: working in a hematology lab; complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics; the parts and functions of the cell; and laboratory testing of blood cells and body fluid cells. UPDATED nearly 700 full-color illustrations and photomicrographs make it easier for you to visualize hematology concepts and show what you'll encounter in the lab, with images appearing near their mentions in the text to minimize flipping pages back and forth. UPDATED content throughout text reflects latest information on hematology. Instructions for lab procedures include sources of possible errors along with comments. Hematology instruments are described, compared, and contrasted. Case studies in each chapter provide opportunities to apply hematology concepts to real-life scenarios. Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference. A bulleted summary makes it easy for you to review the important points in every chapter. Learning objectives begin each chapter and indicate what you should achieve, with review questions appearing at the end. A glossary of key terms makes it easy to find and learn definitions. NEW! Additional content on cell structure and receptors helps you learn to identify these organisms. NEW! New chapter on Introduction to Hematology Malignancies provides and overview of diagnostic technology and techniques used in the lab.

  • 57200lei 515.00 lei

     When a biological drug patent expires, alternative biosimilar products are developed. The development of biosimilar products is complicated and involves numerous considerations and steps. The assessment of biosimilarity and interchangeability is also complicated and difficult.Biosimilar Drug Product Development presents current issues for the development of biosimilars and gives detailed reviews of its various stages and contributing factors as well as relevant regulatory pathways and pre- and post-approval issues.

  • 515.00 lei

    his comprehensive and authoritative text summarizes current evidence and provides experienced perspectives on the etiology, diagnosis, and management of pediatric thrombotic disorders, including arterial ischemic stroke and cerebral sinovenous thrombosis. Authored by leaders in the field, individual chapters are devoted to specific anatomic sites and types of thrombosis. State-of-the-art, pediatric-focused chapters aid in diagnostic evaluation and therapeutic decision making, in settings ranging from the most routine to the most complex and challenging patient scenarios. Topics include: Extremity and Caval Deep Venous Thrombosis; Pulmonary Embolism; Cancer-Associated Thromboembolism; Infection-Associated Thromboembolism; Arterial Ischemic Stroke; Cerebral Sinovenous Thrombosis; Gastrointestinal and Visceral Thrombosis; Developmental Hemostasis; Thrombophilias; Heparin-Induced Thrombocytopenia/Thrombosis Syndrome; Venous Thromboembolism Prevention; Thrombolysis; and Novel Anticoagulants, among others. This text is a 'must-have' for practitioners in pediatric hematology, oncology, hematopoietic stem cell transplantation, neurology, hospital medicine, and intensive care.

  • 61200lei 550.00 lei

    The fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert haematologists, including new co-editor Mark H. Yazer MD.

    ·         A succinct and user-friendly resource of transfusion medicine for clinicians, scientists and trainees with key points, charts and algorithms

    ·         Discusses practice in blood centres and hospitals including regulatory aspects, transfusion safety, production and storage, donor care, and blood transfusion in a global context

    ·         Coverage of cellular and tissue therapies and organ transplantation including stem cell collection and haematopoietic stem cell processing and storage

    ·         Review of the development of the evidence-base for transfusion medicine

    ·         Content on the clinical practice for transfusion and alternatives to transfusion

  • 552.00 lei

    Covering a full range of topics from cardiovascular and pulmonary disease to ophthalmology, hematology and pediatrics, this is the only single volume, quick reference designed for use in daily practice. The 150+ clinical prediction rules as well as the background information necessary to determine its validity and relevance are essential for every physician in a time of limited health care resources. Designed as an aid in diagnosis and treatment, these rules allow more accurate diagnosis and treatment decisions while eliminating superfluous testing.

  • 63500lei 565.00 lei

    Managing patients with thrombotic vascular disease is complex and challenging:

    • Ischemic vascular disease remains a complicated interplay of atherosclerosis and thrombosis—even with the evolution in our understanding of the pathobiology of thrombosis.
    • There has been tremendous growth in therapeutic options which are quickly finding their place in daily practice, including a remarkable expansion in the number of intravenous and oral antithrombotic agents and new antiplatelet agents

    Now more than ever, all cardiologists, hematologists, and specialists in vascular medicine, as well as other professionals, such as hospital pharmacists, who deal with prognosis and intervention in preventing thrombosis, need a resource that distills current knowledge of this important subject.

    Written and edited by today’s leading international, Therapeutic Advances in Thrombosis, 2e provides physicians with the very latest in medical and surgical advances in antithrombotic therapies. With this comprehensively updated edition you get:

    • Coverage of virtually all aspects of venous and arterial thrombotic disease and the corresponding therapies
    • Strategies to manage specific clinical conditions and how to tailor treatment to individual patient needs
    • Updated chapters covering thrombolysis in ST-elevated myocardial infarctions; thrombosis in patients with diabetes, pregnancy, and renal dysfunction
    • Special emphasis on the pharmacology of novel anticoagulants and their practical use in venous thromboembolism and atrial fibrillation.

    Plus, all chapters fully explore clinical trial designs and outcomes for particular treatment therapies, as well as contain the relevant ACC/AHA/ESC guidelines, so you can confidently apply what you learn.

  • 575.00 lei

    Features:

    • Presents a concise, systematic approach to all pediatric hematologic and oncologic disorders in one manual
    • Offers an alternative to bigger references which only cover either oncologic or hematologic disorders in twice as many pages
    • Presents an easy-to-read format: multiple tables, charts, and flow-diagrams for diagnosis and management of pediatric hematologic and oncologic disorders
    • Includes 2 new chapters and several expanded chapters: Diagnostic, Molecular and Genomic Methodologies for the Hematologist, Transfusion Medicine, Myelodysplasia, Myeloid Leukemias, and Lymphoid Leukemias

    Table Of Contents:

    • Dedication
    • List of Contributors
    • About the Editors
    • Preface to the Sixth Edition
    • Preface to the Fifth Edition
    • Preface to the Fourth Edition
    • Preface to the Third Edition
    • Preface to the Second Edition
    • Preface to the First Edition
    • Introduction: Historic Perspective
      • Reflection on 60 Years of Progress in Pediatric Hematology-Oncology
    • Chapter 1. Diagnostic Molecular and Genomic Methodologies for the Hematologist/Oncologist
      • Abstract
      • Clinical Molecular and Genomic Methodologies
      • Interpreting and Evaluating the Results from Clinical Genetic Testing
      • Further Reading and References
    • Chapter 2. Hematologic Manifestations of Systemic Illness
      • Abstract
      • Hematologic Manifestations of Diseases Related to Various Organs
      • Chronic Illness
      • Lead Intoxication
      • Nutritional Disorders
      • Bone Marrow Infiltration
      • Further Reading and References
    • Chapter 3. Classification and Diagnosis of Anemia in Children
      • Abstract
      • Classification and Diagnosis
      • Further Reading and References
    • Chapter 4. Lymphadenopathy and Diseases of the Spleen
      • Abstract
      • Lymphadenopathy
      • Diseases of the Spleen
      • Splenomegaly
      • Further Reading and References
    • Chapter 5. Anemia During the Neonatal Period
      • Abstract
      • Hemorrhage
      • Hemolytic Anemia
      • Failure of Red Cell Production
      • Anemia of Prematurity
      • Physiologic Anemia
      • Diagnostic Approach to Anemia in the Newborn
      • Further Reading and References
    • Chapter 6. Iron-Deficiency Anemia
      • Abstract
      • Prevalence
      • Etiologic Factors
      • Clinical Features
      • Diagnosis
      • Stages of Iron Depletion
      • Differential Diagnosis
      • Treatment
      • Further Reading and References
    • Chapter 7. Megaloblastic Anemia
      • Abstract
      • Vitamin B12 (Cobalamin) Deficiency
      • Folic Acid Deficiency
      • Clinical Features of Cobalamin and Folate Deficiency
      • Diagnosis of Cobalamin and Folate Deficiency
      • Treatment
      • Further Reading and References
    • Chapter 8. Bone Marrow Failure
      • Abstract
      • Aplastic Anemia
      • Acquired Aplastic Anemia
      • Inherited Bone Marrow Failure Syndromes
      • Fanconi Anemia
      • Dyskeratosis Congenita
      • Congenital Aplastic Anemias of Unknown Inheritance
      • Diamond–Blackfan Anemia (Congenital Pure Red Cell Aplasia)
      • Transient Erythroblastopenia of Childhood
      • Congenital Dyserythropoietic Anemia
      • Sideroblastic Anemias (Mitochondrial Diseases with Bone Marrow Failure Syndromes)
      • Severe Congenital Neutropenia and Kostmann Syndrome
      • Reticular Dysgenesis
      • Further Reading and References
    • Chapter 9. General Considerations of Hemolytic Diseases, Red Cell Membrane, and Enzyme Defects
      • Abstract
      • Clinical Features of Hemolytic Disease
      • Laboratory Findings
      • Membrane Defects
      • Paroxysmal Nocturnal Hemoglobinuria
      • Enzyme Defects
      • Further Reading and References
    • Chapter 10. Extracorpuscular Hemolytic Anemia
      • Abstract
      • Immune Hemolytic Anemia
      • NonImmune Hemolytic Anemia
      • Further Reading and References
    • Chapter 11. Hemoglobinopathies
      • Abstract
      • Sickle Cell Disease
      • Thalassemias
      • Management of the Acutely Ill Thalassemic Patient
      • Further Reading and References
    • Chapter 12. Polycythemia
      • Abstract
      • Polycythemia (Erythrocytosis) in the Newborn
      • Polycythemia in Childhood
      • Polycythemia Vera
      • Primary Familial and Congenital Polycythemia
      • Congenital Polycythemia Due to Altered Hypoxia Sensing with Normal P50
      • Congenital Polycythemia Due to Altered Hypoxia Sensing with Decreased P50
      • Other Causes of Polycythemia
      • Diagnostic Approach
      • Further Reading and References
    • Chapter 13. Disorders of White Blood Cells
      • Abstract
      • Quantitative Disorders of Leukocytes
      • Decreased Production or Intrinsic Defects of Neutrophils
      • Increased Destruction or Extrinsic Defects of Neutrophils
      • Immune Neutropenia
      • NonImmune Neutropenia
      • Eosinophils
      • Lymphocytes
      • Disorders of Leukocyte Function
      • Disorders of Adhesion and Chemotaxis
      • Disorders of Neutrophil Granules
      • Disorders of Oxidative Metabolism
      • Neutrophil Production and Destruction in Newborn Infants
      • Neutrophil Function in the Newborn
      • Further Reading and References
    • Chapter 14. Disorders of Platelets
      • Abstract
      • Thrombocytopenia in the Newborn
      • Inherited Thrombocytopenias
      • Immune Thrombocytopenic Purpura (ITP)
      • Other Causes of Thrombocytopenia
      • Thrombocytosis
      • Qualitative Platelet Disorders
      • Acquired Platelet Disorders
      • Nonthrombocytopenic Purpura
      • Further Reading and References
    • Chapter 15. Disorders of Coagulation
      • Abstract
      • Hemostatic Disorders
      • Hemostasis in the Newborn
      • Detection of Hemostatic Defects
      • Acquired Coagulation Factor Disorders
      • Inherited Coagulation Factor Disorders
      • von Willebrand Disease
      • Rare Coagulation Factor Disorders (FII, V, VII, X, XI, XIII, Fibrinogen Deficiencies)
      • Thrombotic Disorders
      • Venous Thrombosis
      • Arterial Thrombosis
      • Antiphospholipid Antibody Syndrome
      • Hereditary Thrombotic Disorders
      • Thrombotic Disorders in Newborns
      • Antithrombotic Agents
      • Antithrombotic Therapy in Special Conditions
      • Further Reading and References
    • Chapter 16. Lymphoproliferative Disorders
      • Abstract
      • Lymphoproliferative Disorders
      • Further Reading and References
    • Chapter 17. Myelodysplastic Syndromes and Myeloproliferative Disorders
      • Abstract
      • Myelodysplastic Syndromes
      • Juvenile Myelomonocytic Leukemia
      • Myeloproliferative Neoplasms
      • CML, BCR–ABL1 Positive
      • Essential Thrombocythemia and Polycythemia Vera
      • Primary Myelofibrosis
      • Further Reading and References
    • Chapter 18. Acute Lymphoblastic Leukemia
      • Abstract
      • Incidence of ALL
      • Etiology
      • Clinical Features of ALL
      • Prognostic Factors
      • Treatment
      • Infant Leukemia
      • Philadelphia-Positive ALL
      • Down Syndrome and ALL
      • Relapse in Children with ALL
      • Future Drugs in ALL Therapy
      • Further Reading and References
    • Chapter 19. Acute Myeloid Leukemia
      • Abstract
      • Incidence and Epidemiology
      • Etiology and Predisposing Conditions
      • Clinical Features
      • Diagnosis
      • Classification of AML
      • Treatment
      • Novel Therapeutic Approaches
      • Acute Promyelocytic Leukemia
      • AML Special Subgroups
      • Further Reading and References
    • Chapter 20. Histiocytosis Syndromes
      • Abstract
      • Langerhans Cell Histiocytosis
      • Other Histiocytic Disorders
      • Macrophage Mediated Disorders
      • Further Reading and References
    • Chapter 21. Hodgkin Lymphoma
      • Abstract
      • Etiology and Epidemiology
      • Risk Factors
      • Biology
      • Pathology
      • Clinical Presentation
      • Diagnostic Evaluation and Staging
      • Prognostic Factors
      • Treatment
      • Long-Term Complications
      • Follow-Up Evaluations
      • Further Reading and References
    • Chapter 22. Non-Hodgkin Lymphoma
      • Abstract
      • Introduction
      • Incidence and Epidemiology
      • Pathologic Classification
      • Clinical Features
      • Diagnosis
      • Staging
      • Prognosis
      • Management
      • Lymphoblastic Lymphoma
      • B Lineage NHL
      • Further Reading and References
    • Chapter 23. Central Nervous System Malignancies
      • Abstract
      • Epidemiology
      • Pathology
      • Clinical Manifestations
      • Genetic Syndromes Associated with Pediatric Brain Tumors
      • Diagnostic Evaluation
      • Treatment
      • Astrocytomas
      • Medulloblastoma
      • Relapsed Medulloblastoma
      • Brain Stem Tumors
      • Ependymomas
      • Optic Glioma
      • Craniopharyngiomas
      • Intracranial Germ Cell Tumors
      • Malignant Brain Tumors in Infants and Children Less Than 3 Years of Age
      • Further Reading and References
    • Chapter 24. Neuroblastoma
      • Abstract
      • Epidemiology
      • Predisposition
      • Pathology and Biology
      • Clinical Features
      • Diagnosis and Staging
      • Treatment
      • Prognosis, Risk Stratification, and Therapy
      • Post-Therapy Monitoring
      • Special Treatment Considerations
      • Neuroblastoma in the Adolescent and Young Adult
      • Further Reading and References
    • Chapter 25. Renal Tumors
      • Abstract
      • Wilms’ Tumor
      • Nephroblastomatosis
      • Congenital Mesoblastic Nephroma
      • Clear Cell Sarcoma of the Kidney
      • Rhabdoid Tumor of the Kidney
      • Renal Cell Carcinoma
      • Further Reading and References
    • Chapter 26. Rhabdomyosarcoma and Other Soft-Tissue Sarcomas
      • Abstract
      • Incidence and Epidemiology
      • Pathologic and Genetic Classification
      • Clinical Features
      • Diagnostic Evaluation
      • Staging
      • Prognosis
      • Treatment
      • Follow-Up After Completion of Therapy
      • Recurrent Disease
      • Future Perspectives
      • Further Reading and References
    • Chapter 27. Malignant Bone Tumors
      • Abstract
      • Osteosarcoma
      • Ewing Sarcoma Family of Tumors
      • Other Bone Tumors
      • Further Reading and References
    • Chapter 28. Retinoblastoma
      • Abstract
      • Incidence
      • Classification
      • 13q Deletion Syndrome
      • Risk for Second Malignant Neoplasms
      • Pathology
      • Clinical Features
      • Diagnostic Procedures
      • Treatment
      • Posttreatment Management
      • Future Perspectives
      • Further Reading and References
    • Chapter 29. Germ Cell Tumors
      • Abstract
      • Incidence
      • Pathology
      • Clinical Features
      • Diagnostic Evaluation
      • Tumor Markers
      • Staging
      • Treatment
      • Further Reading and References
    • Chapter 30. Hepatic Tumors
      • Abstract
      • Incidence
      • Epidemiology
      • Pathology
      • Clinical Features
      • Diagnostic Evaluation
      • Staging
      • Treatment
      • Follow-up
      • Prognosis
      • Further Reading and References
    • Chapter 31. Hematopoietic Stem Cell Transplantation
      • Abstract
      • Allogeneic Stem Cell Transplantation
      • HSC Sources, Collection, and Manipulation
      • Engraftment
      • Complications of HSCT
      • Late Sequelae of Stem Cell Transplantation
      • Further Reading and References
    • Chapter 32. Management of Oncologic Emergencies
      • Abstract
      • Metabolic Emergencies
      • Cardiothoracic Emergencies
      • Abdominal Emergencies
      • Renal Emergencies
      • Neurologic Emergencies
      • Endocrine Emergencies
      • Treatment-Associated Emergencies
      • Further Reading and References
    • Chapter 33. Supportive Care of Patients with Cancer
      • Abstract
      • Management of Infectious Complications
      • Infection Prophylaxis
      • Recognition and Management of Nausea and Vomiting
      • Mucositis
      • Pain Management
      • Nutritional Status of the Oncology Patient
      • Utilization of Hematopoietic Growth Factors
      • Management of Acute Radiation Side Effects
      • Management of CVCs
      • Posttreatment Immunizations
      • Palliative Care
      • Further Reading and References
    • Chapter 34. Evaluation, Investigations, and Management of Late Effects of Childhood Cancer
      • Abstract
      • Musculoskeletal System
      • Cardiovascular System
      • Respiratory System
      • Central Nervous System
      • Endocrine System
      • Genitourinary System
      • Ocular System
      • Auditory System
      • Gastrointestinal System
      • Immunologic System
      • Obesity
      • Second Malignant Neoplasms
      • Psychosocial Issues
      • Further Reading and References
    • Chapter 35. Psychosocial Aspects of Cancer for Children and Their Families
      • Abstract
      • Time of Diagnosis
      • Treatment Initiation
      • Illness Stabilization
      • During Relapses and Recurrences
      • Treatment Outcomes: The Unsuccessful Course
      • Treatment Outcomes: The Successful Course
      • Conclusion
      • Further Reading and References
    • Chapter 36. Blood Banking Principles and Practices
      • Abstract
      • Introduction
      • Donor Selection and Collection
      • Component Preparation
      • Blood Component Modifications
      • Special Pediatric Population Needs
      • Administration
      • Summary
      • Further Reading and References
    • Appendix 1. Hematological Reference Values
      • Fetal and Cord Blood Hematologic Value
      • Red Cell Values and Related Serum Values
      • White Cell Values
      • Platelet Values
      • Coagulation Values
      • Bone Marrow Cells
    • Appendix 2. Biological Tumor Markers
    • Index

  • 600.00 lei

    Written by a team of international experts, this book provides an authoritative overview and practical guide to the molecular biology and genetic basis of haematologic cancers including leukemia. Focusing on the importance of cytogenetics and related assays, both as diagnostic tools and as a basis for translational research, this is an invaluable guide for basic and clinical researchers with an interest in medical genetics and haemato–oncology.

    The Genetic Basis of Haematological Cancers reviews the etiology and significance of genetic and epigenetic defects that occur in malignancies of the haematopoietic system. Some of these chromosomal and molecular aberrations are well established and already embedded in clinical management, while many others have only recently come to light as a result of advances in genomic technology and functional investigation. The book includes seven chapters written by clinical and academic leaders in the field, organised according to haematological malignancy sub–type.
    Each chapter includes a background on disease pathology and the genetic abnormalities most commonly associated with the condition. Authors present in–depth discussions outlining the biological significance of these lesions in pathogenesis and progression, and their use in diagnosis and monitoring response to therapy. The current or potential role of specific abnormalities as novel therapeutic targets is also discussed. There is also a full colour section containing original FISH, microarrays and immunostaining images.

  • 82100lei 600.00 lei

    ​This book is an up-to-date reference on all aspects of anticoagulation and hemostasis in neurosurgery.  After an opening section on basic principles and drug classes in current use, detailed consideration is given to coagulation issues relevant to all patients, not just neurosurgical ones. The coverage includes, for example, deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. A variety of important issues specific to neurosurgical practice are then addressed, and a summary of current guidelines and best practices is provided. By bringing together the latest knowledge from across the discipline, this book will serve as a sound basis for informed decision making in surgical practice. It will be of daily value for neurosurgeons and trainees worldwide and will also be of interest to emergency room physicians, surgeons in general, critical care physicians, neurologists, and hospital medicine specialists.

  • Blood Cells: A Practical Guide, 5th Edition
    La comanda in aproximativ 4 saptamani
    660.00 lei

    • Enables both the haematologist and laboratory scientist to identify blood cell features, from the most common to the more obscure
    • Provides essential information on methods of collection, blood film preparation and staining, together with the principles of manual and automated blood counts
    • Completely revised and updated, incorporating much newly published information: now includes advice on further tests when a specific diagnosis is suspected
    • 400 high quality photographs to aid with blood cell identification • Highlights the purpose and clinical relevance of haematology laboratory tests throughout

  • Leukaemia Diagnosis, 5th Edition
    La comanda in aproximativ 4 saptamani
    75000lei 700.00 lei

    From the bestselling author, Barbara J. Bain, the new edition of this practical reference on the principles of leukaemia diagnosis and classification has been fully updated, and incorporates the recently revised WHO classification.

    Leukaemias are a very heterogeneous group of diseases, which differ from each other in aetiology, pathogenesis, prognosis and responsiveness to treatment. Accurate diagnosis and classification are vital for the identification of specific biological entities and underpin scientific advances in this field. The detailed characterization of haematological neoplasms is also essential for the optimal management of individual patients.

    In this user-friendly guide, Professor Bain illustrates and explains how these many laboratory techniques are used for the diagnosis and classification of leukaemia and related disorders. Leukaemia Diagnosis, Fifth Edition will be highly valuable to trainee haematologists and laboratory scientists in haematology and related disciplines, and will also prove a useful reference source and teaching aid for those who already have expertise in this field. In addition, cytogeneticists and molecular geneticists will find that this book enhances their understanding of the relationship of their disciplines to the diagnosis, classification and monitoring of leukaemia and related disorders.

    Essential reading for every haematologist and haematopathologist, Leukaemia Diagnosis, Fifth Edition features

    • Over 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma supplemented by histological, cytogenetic and immunophenotyping images
    • Recent information on cytogenetic and molecular genetic abnormalities in leukaemia
    • Updated information on the characteristic immunophenotypic characteristics of different categories of leukaemia

  • 723.00 lei

     

    • Provides up-to-date knowledge on the pathogenesis and management of the syndrome
    • Presents and discusses innovative treatments in addition to standard treatment options
    • Describes the involvement of other organs or organ systems

    About this book

    This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss/complications are explained.

    The main clinical manifestations, classification criteria and diagnostic tools are identified, and close attention is paid to the nature of the involvement of various organs or organ systems in APS. Specific chapters describe the treatment of the different symptoms, therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome.

    Reviews

    From the book reviews:

    “The purpose is to provide an overview of this very difficult subject that will benefit bench researchers as well as bedside clinicians. The book would serve any audience who wants to know more about antiphospholipid syndrome. … This is an excellent, up-to-date overview of antiphospholipid syndrome. It will serve as a handy tool to get more information on the topic.” (Dany V. Thekkemuriyil, Doody’s Book Reviews, February, 2015)

     

    Table of contents (20 chapters)

    ·         Genetics and Origin of Antiphospholipid Syndrome

    Soriano, Alessandra (et al.)

    Pages 1-12

    ·         The Paradox of Lupus Anticoagulant

    Banzato, Alessandra (et al.)

    Pages 13-23

    ·         Antiphospholipid Antibody Mechanisms of Thrombosis

    Meroni, Pier Luigi (et al.)

    Pages 25-35

    ·         The Pathogenic Mechanisms for Antiphospholipid Antibodies (aPL)-Mediated Pregnancy Loss

    Simone, Nicoletta (et al.)

    Pages 37-46

    ·         Classification Criteria for the Antiphospholipid Syndrome

    Derksen, Ronald H. W. M. (et al.)

    Pages 47-59

    ·         Non-classification Criteria

    Gerosa, Maria (et al.)

    Pages 61-74

    ·         Obstetric APS

    Fredi, Micaela (et al.)

    Pages 75-87

    ·         APS and the Nervous System

    Chighizola, Cecilia Beatrice (et al.)

    Pages 89-102

    ·         Antiphospholipid Syndrome (APS) and the Renal Involvement

    Mezzina, Nicoletta (et al.)

    Pages 103-112

    ·         Non-Thrombotic Hematologic Manifestations in APS

    Barcellini, Wilma (et al.)

    Pages 113-126

    ·         Heart and APS

    Denas, Gentian (et al.)

    Pages 127-150

    ·         Skin Involvement in Antiphospholipid Syndrome

    Marzano, Angelo Valerio (et al.)

    Pages 151-161

    ·         Additional Organs Involved in Antiphospholipid Syndrome: Eye, Ear-Nose-Throat, Lung, Gastroenteric System, Endocrine Glands

    Santis, Maria (et al.)

    Pages 163-168

    ·         Differential Diagnosis

    Prisco, Domenico (et al.)

    Pages 169-184

    ·         Treatment of Thrombosis in Antiphospholipid Syndrome

    Braham, Simon (et al.)

    Pages 185-192

    ·         Treatment of Pregnancy Complications

    Acaia, Barbara (et al.)

    Pages 193-206

    ·         Antiphospholipid Antibody Carriers

    Dall’Ara, Francesca (et al.)

    Pages 207-218

    ·         New Treatments

    Chighizola, Cecilia Beatrice (et al.)

    Pages 219-232

    ·         Secondary Antiphospholipid Syndrome

    Rahman, Anisur (et al.)

    Pages 233-248

    ·         The

    Rodríguez-Pintó, Ignasi (et al.)

    Pages 249-262

  • 745.00 lei

    The first book on clinical guide to transplantation in lymphoma to present cutting edge knowledge on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies • Provides practical management guidance on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies • Covers an overview of transplantation in lymphoma, and management of the lymphoid malignancies • Discusses organizational aspects of transplant patients and managing a transplant program • Appendices provide practical quick-reference information on follow-up after autologous and allogenic stem cell transplantation in lymphoma

  • 772.00 lei

     

    • A clinically oriented, compact, and up-to-date overview on all aspects of infections in hematology patients
    • Identifies the typical pathogens to be considered in different subgroups of patients
    • Presents clinical, imaging and laboratory-based diagnostic techniques and discusses the therapeutic strategies appropriate to different situations
    • Considers various prophylactic strategies

    About this book

    Infections are among the most frequent complications in patients with hematological malignancies and in those undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation. A profound knowledge on the epidemiology, diagnostic approaches, treatment modalities and prophylactic strategies is essential for the clinical management of these complications in patients who are often severely immunocompromised owing to their underlying diseases and in particular, the intensive myelosuppressive chemo and immunotherapy. This textbook provides a clinically oriented, compact and up-to-date overview on infections in hematology patients and their management. The typical pathogens to be considered in different subgroups of patients are identified and further aspects of the microbiological background are explored.

    Clinical, imaging, and laboratory-based diagnostic techniques are discussed and therapeutic strategies appropriate to different situations are then presented, with due attention to the pitfalls, toxicities and interactions that can arise during antimicrobial treatment. Strategies to prevent infection are also outlined, encompassing antimicrobial prophylaxis, isolation procedures, hospital hygiene, protective immunization and the use of hematopoietic growth factors.

    Reviews

    “This is a comprehensive review of the risk factors, microbiology, prophylaxis, and management of infections in patients with hematological malignancies. … The audience includes students, residents, and practitioners who care for patients with hematological malignancies, and the book targets this group well. … Physicians who care for patients with hematological malignancies need a book like this to give them a comprehensive overview of the support and management of infections in these patients.” (Joseph C. Alvarnas, Doody's Book Reviews, May, 2015)

     

    Table of contents (18 chapters)

     

    ·         Infections in Patients with Acute Leukemia

    Rolston, Kenneth V. I.

    Pages 3-23

    ·         Infections in Patients with Malignant Lymphomas

    Rolston, Kenneth V. I.

    Pages 25-37

    ·         Consequences from Specific Treatment Modalities

    Maschmeyer, Georg

    Pages 39-47

    ·         Infections After High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation

    Nucci, Marcio (et al.)

    Pages 49-61

    ·         Microbiological Background

    Akova, Murat

    Pages 63-87

    ·         The Diagnostic Approach to the Febrile Neutropenic Patient: Clinical Considerations

    Bow, Eric J.

    Pages 91-111

    ·         Diagnostic Radiology in Hematological Patients with Febrile Neutropenia

    Heussel, Claus Peter

    Pages 113-135

    ·         Risk Stratification in Febrile Neutropenic Patients

    Paesmans, Marianne

    Pages 137-152

    ·         Fever of Unknown Origin: Treatment According to Risk Assessment

    Maschmeyer, Georg

    Pages 155-163

    ·         Pulmonary Complications

    Maschmeyer, Georg

    Pages 165-185

    ·         Vascular Catheter-Related Infections

    Dababneh, Luma (et al.)

    Pages 187-195

    ·         Gastrointestinal Complications

    Blijlevens, Nicole M. A.

    Pages 197-210

    ·         Central Nervous System Infections

    Schmidt-Hieber, Martin

    Pages 211-226

    ·         Antibacterial Agents

    Kern, Winfried V.

    Pages 229-258

    ·         Antifungal Agents

    Thompson, George R. (et al.)

    Pages 259-272

    ·         Antimicrobial Prophylaxis in Hematology

    Girmenia, Corrado (et al.)

    Pages 275-296

    ·         Infection Control and Hospital Epidemiology in Hematology Units

    Weisser, Maja (et al.)

    Pages 297-313

    ·         Myeloid Growth Factors

    Link, Hartmut

    Pages 315-324

  • 86600lei 780.00 lei

    This authoritative new book provides a comprehensive overview of diagnostic and therapeutic strategies in hematopoietic cell transplantation, explaining key concepts, successes, controversies and challenges. The authors and editors discuss current and future strategies for major challenges, such as graft-versus-host-disease, including new prophylaxis and treatments. They also discuss long-term complications, such as second malignancies and cardiovascular complications. Chapters are written by leading world experts, carefully edited to achieve a uniform and accessible writing style. Each chapter includes evidence-based explanations and state-of-the-art solutions, providing the reader

  • 89300lei 780.00 lei

    With authoritative coverage of rare and common hemostatic disorders, Consultative Hemostasis and Thrombosis, 4th Edition, keeps you both up to date with all that?s new in this fast-moving field as well as reviewing background and development and citing pertinent classical literature. Broad differential diagnoses are provided, underscoring the editors? position that correct treatment begins with correct diagnosis. This trusted resource by Drs. Craig S. Kitchens, Craig M. Kessler, Barbara A. Konkle, Michael B. Streiff, and David A. Garcia is designed for rapid reference and critical decision making at the point of care. Features: ? Emphasizes real-world problems and solutions, with quick access to concise descriptions of each condition, associated symptoms, laboratory findings, differential diagnosis, and treatment. ? Features a user-friendly design, full-color format, abundant laboratory protocols, and at-a-glance tables and charts throughout. New To This Edition: ? Provides thorough updates on core information on hemostasis and thrombosis, including deep venous thrombosis (DVT), pulmonary embolisms, hypercoagulability, thrombocytopenia, von Willenbrand disease, and more. ? Covers new treatment information on hemophilia A and B. ? Contains new chapters on hereditary hemorrhagic telangiectasia, hemolytic uremic syndrome, and paroxymal nocturnal hemoglobinuria. ? Two new editors, Dr. Michael B. Streiff and Dr. David A. Garcia, offer fresh perspectives and valuable experience. ? Expert Consult? eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

  • 845.00 lei

    Features

    • Histological images and their quantitative examination by cytometry presented side by side
    • Over 350 high-quality images
    • Based on WHO classification of hematopoietic tumors
    • Detailed and up-to-date criteria for diagnosis
    • Systematic approach including basic cases and complicated problem areas

    Summary

    This third edition is the product of the author’s 25 years of experience with flow cytometry; although it covers the wide spectrum of hematopoietic tumors, the focus remains on most important clinical diagnoses, such as acute promyelocytic leukemia, identification of blasts, identification of clonal B-cell population, differentiating mature versus immature T-cell proliferations, deferential diagnosis between hematogones and B-ALL or distinction between chronic and acute monocytic proliferations. All hematopathologists and neoplastic hematologists will find this an important resource for keeping up to date with developments in clinical practice.

  • 845.00 lei

    Hematologic malignancies were the first human cancers to be studied in depth at the molecular level, and recent years have seen important advances in treatment. This comprehensive reference book covers the full range of hematologic malignancies, including all subtypes of leukemias, lymphomas, and plasma cell dyscrasias. Authored by internationally known experts, each chapter emphasizes diagnostic work-up, staging, and therapeutic approaches. Up-to-date hematopathology, treatment, and outcomes data are presented in a way which is directly applicable to patient care. Highly illustrated with color images, graphs, flowcharts and treatment algorithms, the book is perfect for quick clinical reference as well as providing detailed reference lists for further study. With its authoritative and practical focus and visually stimulating presentation, this is a key text for hematology and oncology fellows, physicians, oncology nurses, physician assistants and other healthcare workers in the field of oncology. Covers epidemiology, etiology, risk-factors, clinical presentation, diagnosis, staging and treatment strategies for each disease subset Color images, graphs, flowcharts, algorithms and tables enhance the presentation and clinical utility of the text Extensive reference lists enable further reading and study

  • 98100lei 850.00 lei

    Provides coverage of the pathogenesis, clinical, morphologic, molecular and investigational aspects of a full range of blood disorders seen in daily practice The revised fifth edition of this renowned atlas presents readers with a comprehensive, visual guide to clinical hematology, featuring 2700 full-color photographs and figures depicting the spectrum of hematological diseases. Ranging from photographs of the clinical manifestations and key microscopic findings to diagrams of the molecular aspects of these diseases, the book provides up-to-date information of the blood diseases that clinicians encounter every day. Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease offers the reader an understanding of normal cell machinery, and of the molecular basis for such processes as DNA and cell replication, RNA species, trafficking and splicing, protein synthesis, transcription factors, growth factor signal transduction, epigenetics, cell differentiation, autophagy, and apoptosis. The text goes on to explore how these processes are disturbed in the various diseases of the bone marrow, blood, and lymphoid systems. Helps solve difficult diagnostic challenges and covers complex principles using highly illustrative, full-color images Explores all aspects of benign and malignant hematology, including blood transfusion and coagulation with extensive coverage of the pathogenesis of common clinical entities Provides a quick and easy reference of key diagnostic issues in a comprehensive yet concise format Includes and illustrates the WHO Classification of Hematologic Malignancies Illustrates the new knowledge of the molecular basis of inherited and acquired blood diseases Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease is the must-have resource for both trainee and practising hematologists, and for every department of hematology.

  • 1,16300lei 980.00 lei

    First published in 2006, the bestselling Wintrobe's Atlas of Clinical Hematologyhas now been comprehensively updated by a brand-new editorial team to bring you state-of-the-art pictorial coverage of the complete range of hematologic conditions. Thousands of meticulous, full-color images capture the characteristic appearance of each pathologic entity, and concise descriptions point out features of diagnostic importance. The result is a peerless reference to facilitate confident diagnosis in hematology.

    Features:

    Access the latest knowledge in the field with more than 30% new or updated content - including expanded coverage of acute lymphoblastic leukemia (ALL); revised diagnostic criteria for fluorescent in situ hybridization (FISH); enhanced information on flow cytometry; new coverage of genetic screens, circulating DNA analysis, RT-PCR, exosome analysis, and evaluation of epigenetic abnormalities; completely new chapters on hemostasis and platelets as well as on plasma cell disorders and on benign diseases of leukocytes, spleen, and immunoglobins; and much more.Vividly visualize the presentation of every hematologic disorder thanks to thousands of crisp, full-color images, hundreds of them new to this edition.Locate the information you need more easily through a new, highly templated format that expedites navigation, as well as a new index of figures by disorder.Easily find additional in-depth answers inside Wintrobe's Clinical Hematology, the best-selling comprehensive reference in the field, since this Atlas now features a parallel organization.Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time - providing a seamless reading experience online or offlinePowerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooksMultiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive designThe ability to highlight text and add notes with one click

  • 1,10100lei 990.00 lei


    Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team.
    Features: • Content is templated and divided into three sections -- Scientific Foundations of Radiation Oncology, Techniques and Modalities, and Disease Sites - for quick access to information.
    • Disease Sites chapters summarize the most important issues on the opening page and include a full-color format, liberal use of tables and figures, a closing section with a discussion of controversies and problems, and a treatment algorithm that reflects the treatment approach of the authors.
    • Chapters have been edited for scientific accuracy, organization, format, and adequacy of outcome data (such as disease control, survival, and treatment tolerance).
    • Allows you to examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches.
    • Features an emphasis on providing workup and treatment algorithms for each major disease process, as well as the coverage of molecular biology and its relevance to individual diseases.
    New To This Edition:

    • Two new chapters provide an increased emphasis on stereotactic radiosurgery (SRS) and stereotactic body irradiation (SBRT).
    • New Associate Editor, Dr. Andrea Ng, offers her unique perspectives to the Lymphoma and Hematologic Malignancies section.
    • Key Points are summarized at the beginning of each disease-site chapter, mirroring the template headings and highlighting essential information and outcomes.
    • Treatment algorithms and techniques, together with discussions of controversies and problems, reflect the treatment approaches employed by the authors.
    • Disease Site Overviews allow each section editor to give a unique perspective on important issues, while online updates to Disease Site chapters ensure your knowledge is current.
    • Disease Site chapters feature updated information on disease management and outcomes.
    • Four videos accessible on Expert Consult include Intraoperative Irradiation, Prostate Brachytherapy, Penile Brachytherapy, and Ocular Melanoma.
    • Thirty all-new anatomy drawings increase your visual understanding.
    • Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

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