Moyamoya Disease: Current Knowledge and Future Perspectives

Description:

This book brings together the latest knowledge on moyamoya disease, covering diagnostic criteria, status as a disease entity, genetic aspects, pathophysiology, novel neuroradiological findings, and surgical therapy. Information is also provided on recent basic and clinical research with the aim of identifying future perspectives on the disease. Since moyamoya disease was first reported in an English language article more than 50 years ago, our understanding of it has advanced considerably. Genetic and radiological analysis has delivered novel insights, and the latest multicenter studies are changing routine diagnosis and surgical therapy. The gene encoding the ring finger protein 213 (RNF213) has been identified as a susceptibility gene for moyamoya disease. Indications and procedures for surgical revascularization have been revised, with resultant improvements in outcomes, and studies performed over the past decade have provided new knowledge on the neuroradiological findings before and after surgery. In describing these advances, this book will be an invaluable asset for all general physicians, pediatricians, neurologists, radiologists, and neurosurgeons who care for patients with moyamoya disease across the world.

Table of Contents:

Part I. Concept of Moyamoya Disease

1. History of Disease Entity and Diagnosis Criteria

2. Moyamoya Syndrome

3. Unilateral Moyamoya Disease: A Distinct Entity?

Part II. Genetic Aspect of Moyamoya Disease

4. RNF213 as a Susceptibility Gene for Moyamoya Disease has Multifunctional Roles in Biological Processes

5. RNF213 and Clinical Feature

6. RNF213 Variant as a Biomarker of Cerebrovascular Disease

Part III. Pathophysiology of Moyamoya Disease

7. TIA and Headache in Pediatric Moyamoya Disease

8. Ischemic Stroke

9. Hemorrhagic Stroke and the Japan Adult Moyamoya Trial

10. Cognitive Function in Pediatric Moyamoya Disease

11. Cognitive Dysfunction in Adults

12. Asymptomatic Moyamoya Disease

Part IV. Update on Neuroradiology in Moyamoya Disease

13. Periventricular Anastomosis

14. Arterial Shrinkage

15. Disease Progression

16. Postoperative Hyperperfusion

17. Postoperative FLAIR Imaging Changes

Part V. Real World of Surgical Revascularization for Moyamoya Disease

18. Overview of Surgical Revascularization and Long-Term Outcome in Japan

19. Perioperative Complications

20. Long-Term Outcome in Europe

21. Long-Term Outcomes in the USA

22. Long-Term Outcome in China

23. Long-Term Outcome of Revascularization Surgery for Moyamoya Disease in Korea

24. Indirect Bypass Surgery for Moyamoya Disease

25. Direct/Combined Bypass Surgery

26. Special Considerations: Infants

27. Special Considerations: Elderly