Mesothelioma. From Research to Clinical Practice

Description:

This book offers an updated review of malignant mesothelioma, including the latest advances in our understanding of its genetic control and molecular biology, as well as pre-clinical and clinical research. It also presents state-of-the-art diagnostic approaches and therapeutic options, and an open discussion on the future prospects for patient management. Malignant mesothelioma is an enormous global health problem related to asbestos exposure. Despite the best efforts of scientists and oncologists, the prognosis for those affected remains poor. Due to anatomical characteristics and non-specific symptoms, the diagnosis of mesothelioma at an early stage is often difficult, while surgery and radiotherapy are only of limited use, even if some multimodality approaches seem promising. In turn, medical treatments are sometimes successful in tumor control, but have little impact on overall survival. However, advances in our understanding of the disease’s biology, together with the availability of new drugs and combinations, make mesothelioma an essential and highly topical field for pre-clinical and clinical studies. This book is subdivided into four parts: epidemiology and preclinical data, diagnosis, therapy, and extrathoracic mesothelioma. It highlights the progress made in a variety of areas – e.g. in vitro and in vivo experimental models, genetics, environment, biomarkers, targeting agents, immunotherapy, metabolic imaging and ongoing clinical trials – and describes the standard clinical management of mesothelioma patients, including those with extra-thoracic localizations. Given its scope, the book offers an invaluable tool for researchers, oncologists and clinicians alike.

Table of Contents:

1. Epidemiology of Mesothelioma

2. Asbestos and the Pathophysiology of Mesothelioma

3. Screening Issues in Exposed Subjects and Early Diagnosis

4. Genetics and Epigenetics of Mesothelioma

5. Microenvironment and Immunology of the Human Pleural Malignant Mesothelioma

6. Preclinical Models in Mesothelioma

7. Pathological Diagnosis of Mesothelioma

8. Tissue and Circulating Biomarkers in Mesothelioma

9. Diagnostic Imaging of Mesothelioma

10. Measuring Malignant Pleural Mesothelioma

11. Role of Metabolic Imaging in Mesothelioma

12. Staging of Malignant Pleural Mesothelioma

13. Surgery and Multimodality Treatment in Malignant Pleural Mesothelioma

14. Role of Radiotherapy in Malignant Pleural Mesothelioma

15. Role of Chemotherapy in the Management of Malignant Pleural Mesothelioma

16. Targeting Angiogenesis in Malignant Pleural Mesothelioma

17. Targeted Therapies in Mesothelioma

18. Mesothelin-Targeted Agents in Mesothelioma

19. Immunotherapy of Mesothelioma: Vaccines and Cell Therapy

20. Immunotherapy, the Promise for Future of Mesothelioma Treatment?

21. Peritoneal Mesothelioma: Diagnosis and Management

22. Rare Localizations of Mesothelioma

23. Unmet Needs and Future Outlook of Mesothelioma Management