Atlas of Gastrointestinal Pathology

 

Description:

 

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Closely mirroring the daily sign-out process, Atlas of Gastrointestinal Pathology: A Pattern Based Approach to Neoplastic Biopsies is a highly illustrated, efficient guide to accurate diagnosis. This practical reference uses a proven, pattern-based approach to clearly explain how to interpret challenging cases by highlighting red flags in the clinical chart and locating hidden clues in the slides. Useful as a daily “scope-side guide,” it features numerous clinical and educational features that help you find pertinent information, reach a correct diagnosis, and assemble a thorough and streamlined pathology report.

 

Table of Contents:

 

Esophagus 1

The Unremarkable Esophagus

Some Esophageal Polyps

Granular Cell Tumor

Leiomyoma

Gastrointestinal Stromal Tumors of the Esophagus

Barrett Esophagus

Grading Barrett Dysplasia

Barrett Esophagus, Negative for Dysplasia

Barrett Esophagus Indefinite for Dysplasia

Low-Grade Dysplasia

High-Grade Dysplasia

Intramucosal Adenocarcinoma and Adenocarcinoma

Endoscopic Mucosal Resection Specimens

Dysplasia Recapitulation

Squamous Neoplasia

Risk Factors

Squamous Carcinoma Precursor Lesions

Squamous Dysplasia

Epidermoid Metaplasia

Squamous Cell Carcinoma

Near Misses

What Went Wrong?

Neuroendocrine Tumors of the Esophagus

Adenosquamous Carcinoma

Spread of Extraesophageal Carcinoma to the Esophagus

Melanoma

Esophageal Hematopoietic Disorders

Stomach 2

The Unremarkable Stomach

Polyps

Pancreatic Heterotopia

Hamartomatous Polyps and Syndromic Considerations

Peutz-Jeghers Polyp

Juvenile Polyp

Cronkhite-Canada Syndrome Polyp

PTEN Hamartoma Tumor Syndrome and Cowden Syndrome Polyp

Epithelial Polyps

Hyperplastic Polyp

Fundic Gland Polyp

Adenomatous Polyps

Gastric Adenoma, Intestinal Type

Gastric Adenoma, Foveolar Type

Pyloric Gland Adenoma

Oxyntic Gland Polyp/Adenoma

Adenocarcinoma

Approach to the Biopsy

Tumor Location and StagingEsophageal Versus Gastric

Tumor ClassificationLauren, Ming, and WHO Morphologic Variants

Risk Factors and Genetic Considerations

Background Mucosa

Environmental Risk Factors

Familial Predisposition

Biomarker Testing 101

Programed Death Receptor-1/Programed Death Ligand-1 (PD-1/PD-L1)

Human Epidermal Growth Factor Receptor 2 (HER2)

Well-Differentiated Neuroendocrine Tumors (Formerly “Carcinoid”)

Gastric Well-Differentiated Neuroendocrine Tumor, Type I

Gastric Well-Differentiated Neuroendocrine Tumor, Type II

Gastric Well-Differentiated Neuroendocrine Tumor, Type III

MALT Lymphoma

Mesenchymal Lesions

Inflammatory Fibroid Polyp

Gastrointestinal Stromal Tumor

Leiomyoma

Granular Cell Tumor

Near Miss

Metastatic Lobular Breast Carcinoma

Gastric Xanthoma

Gastritis Cystica Profunda

Inactive Chronic Gastritis Hides Tumors

Small Bowel 3

The Unremarkable Small Bowel

Polyps

Heterotopic Polyps

Pancreatic Heterotopia

Gastric Heterotopia

Hyperplastic

Brunner Gland Proliferative Lesion (Hyperplasia, Hamartoma, or Adenoma)

Hamartomatous Polyps and Syndromic Considerations

Peutz-Jeghers Polyp

Juvenile Polyp

Cronkhite-Canada Syndrome Polyps

PTEN Hamartoma Tumor Syndrome and Cowden Syndrome Polyps

Adenomatous Polyps

Conventional Adenoma

Pyloric Gland Adenoma

Adenocarcinoma

Approach to the Biopsy

Tumor Location and StagingDuodenal Versus Ampullary

Neuroendocrine Tumors and Neuroendocrine Carcinomas

Well-Differentiated Neuroendocrine Tumors (Formerly “Carcinoid”)

Poorly Differentiated Neuroendocrine Carcinoma

Near Miss

Crushed Brunner Glands

Endometriosis

Lymphangioma

Metastatic Clear Cell Renal Cell Carcinoma

Duodenal-Type Follicular Lymphoma

Systemic Mastocytosis

Colon 4

The Unremarkable Colon

Polyps

Conventional Adenomatous Polyps

Classification

Dysplasia Grading

The Microanatomy of a Malignant Polyp

Epithelial Misplacement as a Mimic of Invasion

Squamous Morules as a Mimic of Invasion

Serrated Polyps

ClassificationUnwinding the Serrated Polyp Nomenclature

Dysplastic Serrated Polyps

Ugly Cauterized Polyps

Syndromic Considerations

Lynch Syndrome

Familial Adenomatous Polyposis

MUTYH-Associated Polyposis

Serrated Polyposis Syndrome

Hamartomatous/Inflammatory-type Polyp Syndromes

Dysplasia in Inflammatory Bowel Disease

Clinical Considerations

Dysplasia Grading

Adenocarcinoma

Approach to the Biopsy

Molecular Pathways 101

Chromosomal Instability Pathway

Microsatellite Instability Pathway

CpG Island Methylator Phenotype

Biomarker Testing 101

Mismatch Repair Immunohistochemistry

Immune Surveillance Pathways

Programmed Death Receptor-1/Programmed Death Ligand-1

Tissue Preparation for PD-L1 IHC

PD-L1 IHC Interpretation

Cytotoxic T-Lymphocyte–Associated Antigen 4

Her2 in Colorectal Carcinoma

Near Miss

Beware the Suboptimal Biopsy

Extracolonic Neoplasms Involving the Colon

Endometriosis

Sneaky Diagnoses With Inflammatory Infiltrates

Sexually Transmitted Infectious Proctitis

Malignant Hematolymphoid Processes

Merkel Cell Carcinoma

Other “Forget Me Nots”

Spirochetosis

Amyloid

Anus 5

The Unremarkable Anus

Nondysplastic Polyps

Hemorrhoids

Fibroepithelial Polyps

Inflammatory Cloacogenic Polyp

Hidradenoma Papilliferum

HPV-Associated Neoplasms

Overview

LAST Highlights

Uniform Grading Scheme

Two-Tiered System

LSIL, Including Condyloma Acuminatum

HSIL

Biomarkers

Squamous Cell Carcinoma

Measurement Tips

Histology

Invasion Mimics

Verrucous Carcinoma and Giant Condyloma (Buschke-Lowenstein Tumor)

Adenocarcinoma

Metastasis or Direct Invasion

Anal Duct Carcinoma

Adenocarcinoma Arising in Fistulous Disease

Extramammary Paget Disease

Malignant Melanoma

Near Miss

Beyond the First Diagnosis

Unexpected Findings in a Hemorrhoid

Papillary Endothelial Hyperplasia

Epstein-Barr Virus Mucocutaneous Ulcer

Syphilitic and Lymphogranuloma Venereum Proctocolitis (STI Proctitis)

Unexpected Herpes Simplex Virus

Mesenchymal Lesions 6

The Layout of the Real Estate

Immunolabeling Comments

Immunolabeling

Mesenteric Lesions

Mesenteric Fibromatosis

Sclerosing Mesenteritis

Inflammatory Myofibroblastic Tumor

IgG4-Related Fibrosclerosing Disease

Translocation Sarcomas Associated With the Gastrointestinal Tract

General Comments

Ewing Sarcoma

Clear Cell Sarcoma–Like Tumor of the Gastrointestinal Tract

Low-Grade Fibromyxoid Sarcoma

Synovial Sarcoma

Other Spindle Cell Lesions

Gastrointestinal Stromal Tumor

Diagnosing Gastrointestinal Stromal Tumors

Mutational Analysis in Gastrointestinal Stromal Tumors

Prognostication in Gastrointestinal Stromal Tumors

Succinate Dehydrogenase–Deficient Gastrointestinal Stromal Tumors

Microscopic Incidental Gastric Gastrointestinal Stromal Tumors

Inflammatory Fibroid Polyp

Smooth Muscle Neoplasms

Plexiform Fibromyxoma

Schwannoma

Glomus Tumor

Calcifying Fibrous Tumor

Follicular Dendritic Cell Sarcoma

Rosai-Dorfman Disease

Summary of Gastrointestinal Tract Lesions Containing Many Inflammatory Cells

Select Colorectal Lesions Likely to Be Encountered on Biopsies

Ganglioneuroma

Mucosal Neuromas Associated With MEN IIB

Neurofibromas

Schwann Cell Hamartoma

Epithelioid Nerve Sheath Tumor (Epithelioid Schwannoma)

Granular Cell Tumor

Perineurioma

Summary of Neural Polyps

Near Miss

Case

What Went Wrong?

Endometrial Lesions (Endometriosis and Endometrial Stromal Sarcoma)

A Few Vascular Tumors

Anastomosing Hemangioma

Malignant Vascular Lesions

Near Miss

Case

What Went Wrong?

Appendix A

Appendix B

Index

 

An aparitie	1 Jan. 2019
Autor	Christina Arnold M.D., Dora Lam-Himlin M.D., Elizabeth A. Montgomery MD
Dimensiuni	22.1 x 2.79 x 28.19 cm
Editura	LWW
Format	Hardcover
ISBN	9781496367549
Limba	Engleza
Nr pag	656