Antiepileptic Drug Interactions

 

Description:

This updated third edition of a successful book is a description of both pharmacokinetic and pharmacodynamic antiepileptic drug (AED) interactions, including details of the magnitude and mechanism of interactions, and also of drug combinations that are not associated with interactions and therefore can be coprescribed without undue concern. Presented in alphabetical order and by drug class, drug interactions that occur between AEDs and also between AEDs and non-AEDs are described in three sections: Drug interactions between AEDs; Drug interactions between AEDs and non-AED Drugs: Interactions affecting AEDs; Drug interactions between AEDs and non-AED Drugs: Interactions affected by AEDs. Antiepileptic Drug Interactions: A Clinical Guide, 3rd Edition with its clear, concise and unambiguous content will allow physicians and allied health professionals to make more rational choices when AED polytherapy regimens are indicated. There is always a choice and avoiding highly interacting drugs and choosing drug combinations that are minimally interacting or do not interact should be the goal in treating patients with epilepsy. This book provides all the necessary information so as to allow this goal to be achieved and, if necessary, to aid effective management of AED interactions.

 

 

Table of Contents:

 

Mechanisms of Drug Interaction

Pharmacodynamic Interactions

Pharmacokinetic Interactions

Interactions Affecting Drug Absorption

Plasma Protein Binding Displacement Interactions

Interactions at the Renal Level

Metabolic Interactions

CYP Enzymes

Epoxide Hydrolases

Uridine Glucuronyl Transferases

Enzyme Inhibition

Enzyme Induction

Anticipating and Predicting Metabolic Interactions

Factors That Impact on the Relevance of a Metabolic Interaction

Prevention and Management of Adverse AED Interactions

The Role of Therapeutic Drug Monitoring in the Management of AED Interactions

References

Part I: Drug Interactions Between AEDs

Acetazolamide

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

Reference

Brivaracetam

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Carbamazepine

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Clobazam

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Clonazepam

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Eslicarbazepine Acetate

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Ethosuximide

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Felbamate

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Gabapentin

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Lacosamide

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Lamotrigine

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Levetiracetam

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Methsuximide

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Oxcarbazepine

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Perampanel

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Phenobarbital

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Phenytoin

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Piracetam

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Pregabalin

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Primidone

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Retigabine

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Rufinamide

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Stiripentol

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Sulthiame

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Tiagabine

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Topiramate

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Valproic Acid

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Vigabatrin

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Zonisamide

Pharmacokinetic Characteristics

Absorption and Distribution

Biotransformation

Renal Excretion

Elimination

Effects on Isoenzymes

Therapeutic Drug Monitoring

Propensity to Be Associated with Pharmacokinetic Interactions

Interactions with AEDs

References

Part II: Drug Interactions Between AEDs and Non-�AEDs: Interactions Affecting AEDs

Acetazolamide

Brivaracetam

References

Carbamazepine

Analgesics

Antibacterials

Antifungal Agents

Antineoplastic Agents

Antituberculous Agents

Antiulcer Drugs

Histamine H2-Receptor Antagonists

Proton Pump Inhibitors

Antiviral Agents

Atkins Diet (Modified)

Cardiovascular Drugs

Antiarrhythmics

Antihypertensive Agents

Antiplatelet Drugs

Lipid-Lowering Drugs

Oral Anticoagulants

Herbal Remedies

Psychotropic Drugs

Antidepressants

Antipsychotics

Steroids

Miscellanea

References

Clobazam

References

Clonazepam

References

Eslicarbazepine Acetate

Ethosuximide

References

Felbamate

References

Gabapentin

References

Lacosamide

References

Lamotrigine

Analgesics

Antimicrobials

Antituberculous Agents

Antifungal Agents

Antiviral Agents

Antiulcer Drugs

Histamine H2-Receptor Antagonists

Psychotropic Drugs

Antidepressants

Antipsychotics

Steroids

Miscellanea

References

Levetiracetam

References

Methsuximide

Oxcarbazepine

References

Perampanel

Reference

Phenobarbital

References

Phenytoin

Analgesics

Antibacterials

Antifungal Agents

Antineoplastic Agents

Antituberculous Agents

Antiulcer Drugs

Antacids and Surface-Acting Drugs

Histamine H2-Receptor Antagonists

Proton Pump Inhibitors

Antiviral Agents

Cardiovascular Drugs

Antiarrhythmics

Antihypertensive Agents

Antiplatelet Drugs

Digoxin

Lipid-Lowering Drugs

Oral Anticoagulants

Herbal Remedies

Psychotropic Drugs

Antidepressants

Antipsychotics

Steroids

Miscellanea

References

Piracetam

Reference

Pregabalin

References

Primidone

References

Retigabine

References

Rufinamide

Stiripentol

Sulthiame

Reference

Tiagabine

References

Topiramate

References

Valproic Acid

Analgesics

Antibacterials

Antifungal Agents

Antineoplastic Agents

Antituberculous Agents

Antiulcer Drugs

Antacids and Surface-Acting Drugs

Histamine H2-Receptor Antagonists

Antiviral Agents

Cardioactive Drugs

Psychoactive Drugs

Antidepressants

Antipsychotics

CNS Stimulants and Drugs Used for Attention Deficit Disorders

Steroids

Miscellanea

References

Vigabatrin

Part III: Drug Interactions Between AEDs and Non-�AEDs: Interactions Affected by AEDs

Analgesics

Codeine

Diflunisal

Fentanyl

Meperidine (Pethidine)

Methadone

Morphine

Naproxen

Oxycodone

Paracetamol

References

Antineoplastic Agents

9-Aminocamptothecin

Busulphan

CCNU (1-(2-Chloroethyl)-3-Cyclohexyl-1-Nitrosourea)

Celecoxib

Cisplatin

Cyclophosphamide

Cytarabine

Etoposide

Gefitinib

Glufosfamide

Ifosfamide

Imatinib

Irinotecan

Lapatinib

Methotrexate

Paclitaxel

Pomalidomide

Procarbazine

Tamoxifen

Temozolomide

Temsirolimus

Teniposide

Thiotepa

Topotecan

Vincristine

References

Antiulcer Drugs

Histamine H2-Receptor Antagonists

Cimetidine

Proton-Pump Inhibitors

Omeprazole

References

Cardiovascular Drugs

Antianginals

Ivabradine

Antiarrhythmics

Amiodarone

Disopyramide

Mexiletine

Quinidine

Antihypertensive Agents

Atenolol

Diazoxide

Digoxin

Diltiazem

Felodipine

Losartan

Nifedipine

Nilvadipine

Nimodipine

Nisoldipine

Propranolol

Verapamil

Diuretics

Furosemide (Frusemide)

Hydrochlorothiazide

Oral Anticoagulants

Dicoumarol

Phenprocoumon

Warfarin

Statins

Atorvastatin

Simvastatin

References

Immunosuppressants

Cyclosporine A

Lamivudine

Mycophenolate

Sirolimus

Tacrolimus

References

Neuromuscular Blocking Agents

Atracurium

Cisatracurium

Doxacurium

Mivacurium

Pancuronium

Pipecuronium

Rapacuronium

Rocuronium

Vecuronium

References

Psychotropic Drugs

Antidepressants

Amitriptyline

Citalopram

Clomipramine

Desipramine

Doxepin

Fluoxetine

Imipramine

Mianserin

Mirtazapine

Moclobemide

Nefazodone

Nortriptyline

Paroxetine

Sertraline

Venlafaxine

Viloxazine

Antipsychotics

Amisulpride

Aripiprazole

Asenapine

Bromperidol

Chlorpromazine

Clozapine

Fluphenazine

Haloperidol

Olanzapine

Paliperidone

Quetiapine

Risperidone

Thioridazine

Trazodone

Ziprasidone

Benzodiazepines

Alprazolam

Clobazam

Clonazepam

Diazepam

Lorazepam

Midazolam

Lithium

References

Steroids

Corticosteroids

Cortisol/Hydrocortisone

Dexamethasone

Methylprednisolone

Prednisolone

Oral Contraceptives

References

Miscellanea

Alcohol

Armodafinil

Bupropion

Dexmedetomidine

Dextromethorphan

Dihydroergotamine

Fexofenadine

Flunarizine

Gamma-Hydroxybutarate

Glibenclamide (Glyburide)

Isoxicam

Levodopa

Lidocaine (Lignocaine)

Metformin

Metyrapone

Oxiracetam

Pioglitazone

Pizotifen

Propofol

St John’s Wort (Hypericum perforatum)

Sumatriptan

Theophylline

Tirilazad

Tolbutamide

Triazolam

Valnoctamide

Zolpidem

References

Index

 

An aparitie	2016
Autor	Patsalos
Dimensiuni	15.49 x 2.26 x 23.5 cm
Editura	Springer
Format	Softcover
ISBN	9783319329086
Limba	Engleza
Nr pag	389