Inflamația este implicată intr o multitudine de procese fiziologice și fiziopatologice. Progresele științifice actuale cu privire la înțelegerea reacțiilor inflamatorii sunt impresionante.  Probabil, următorii ani vor elucida rolul condițiilor inflamatorii asociate cu boli moderne prevalente în societatea contemporană. Fiziologia și fiziopatologia inflamației reprezintă un sprijin util pentru înțelegerea și însușirea informațiilor științifice actualizate despre reacțiile inflamatorii, structurat în nouă capitole.

Ultimul capitol conține întrebări cu răspunsurile incluse, având ca obiectiv, alături de întregul manuscris, să sprijine studenții și medicii să își aprofundeze și să își verifice cunoștințele, să capete încredere în cazul susținerii unor examene, precum și să faciliteze aplicarea unor concepte fiziopatologice în practica clinică.

Înţelegerea mecanismelor imunologice îndreptate împotriva melanocitelor benigne şi maligne reprezintă un subiect relevant pentru cercetare în momentul actual, întrucât creează premisa dezvoltării de noi terapii imunologice atât în melanom, cât şi în vitiligo, cu rezultate promiţătoare.

În practică, reacţiile imunologice antimelanocitare pot fi studiate în diferite situaţii clinice: în vitiligo, unde procesele imunologice sunt supraexprimate; în nevii Sutton, unde mecanismele imunologice sunt adecvate; în melanom, în care imunosupresia locală împiedică de cele mai multe ori fenomenele antitumorale să acţioneze eficient. Lucrarea prezentă reunește multe dintre studiile autoarei referitoare la aceste mecanisme fiziopatologice, realizate și publicate

în ultimii zece ani în teza de doctorat, precum și proiectele postdoctorale și articolele de specialitate. Realizează totodată actualizarea materialelor cu cele mai recente informații din literatura medicală cu privire la: structura sistemului imun cutanat şi a funcţiei principalelor componente ale acestuia; mecanismele prezente în autoimunitate, autoinflamaţie şi imunitatea antitumorală cutanate; reacţiile imunologice îndreptate împotriva melanocitelor benigne şi maligne în vitiligo, în melanom (regresie) și în nevii melanocitari (nevii Sutton).

Packed with practical, up-to-date guidance, Essentials of Physical Medicine and Rehabilitation, 4th Edition, by Walter R. Frontera, MD, PhD; Julie K. Silver, MD; and Thomas D. Rizzo, Jr., MD, helps you prevent, diagnose, and treat a wide range of musculoskeletal disorders, pain syndromes, and chronic disabling conditions in day-to-day patient care. This easy-to-use reference provides the information you need to improve patient function and performance by using both traditional and cutting-edge therapies, designing effective treatment plans, and working with interdisciplinary teams that meet your patients’ current and changing needs. An easy-to-navigate format provides quick access to concise, well-illustrated coverage of every essential topic in the field.

 Gain a solid understanding of musculoskeletal ultrasound anatomy, pathology, and technique with the second edition of this award-winning reference. Written by Dr. James F. Griffith and other leading experts in the field, Diagnostic Ultrasound: Musculoskeletal offers more than 100 detailed, clinically-oriented chapters of ultrasound anatomy, technique, diagnosis, differential diagnosis, reporting, and ultrasound-guided interventional procedures for the entire musculoskeletal system. This wealth of updated information helps you achieve an accurate musculoskeletal ultrasound diagnosis for every patient.

This landmark book, a reference work now in its second edition, provides healthcare practitioners in neonatology with an up-to-date, comprehensive source of readily accessible practical advice that will assist in the expert management of patients and their diverse illnesses. Leading experts in their fields discuss the underlying causes and mechanisms and all aspects of the treatment of the full range of neonatal diseases and abnormalities, citing the evidence base whenever appropriate. In addition, detailed information is provided on epidemiology and fetal medicine; therapeutic issues such as the organization of care, transport services, and home care after discharge; legal issues; nutrition; and the consequences of medication use during pregnancy, maternal drug abuse and smoking, and maternal diabetes. The inclusion of summaries, tables, and carefully selected guidelines and recommendations will supply practitioners with quick references and instant solutions during daily practice. The book will be a superb resource for all involved in the care of newborn babies, including neonatologists, pediatricians, pediatric surgeons, anesthesiologists, midwives, and nursing staff. It is published within the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.

This book presents the basic concepts for understanding and practicing breast pathology in routine practice. It explains how to tackle the diagnosis, emphasizing diagnostic clues for each entity as well as pitfalls and mimickers. Each chapter has concise, relevant text illustrated by numerous high-quality pictures highlighting the pearls and challenges in the diagnosis of breast lesions. Experts from around the world describe common and rarer conditions affecting the breast. Histology, immunohistochemistry, cytology, radiology and key morphologic criteria are covered. The book includes a chapter dedicated to breast normal histology, which is very important for understanding breast pathology, and a separate chapter for breast radiology, which is essential in understanding and diagnosing the breast lesions especially in a multidisciplinary team. Also, there is a chapter with the latest TNM staging system as well as the recently revised World Health Organization classification of breast tumors. Since in many breast units the cytology is still used to diagnose breast lesions there is a chapter dedicated to this technique. This book is aimed at trainees and practicing pathologists in surgical pathology, particularly those with an interest in breast pathology and those tackling the daily sign-out.

From basic science to practical clinical tools, Chronic Kidney Disease, Dialysis, and Transplantation, 4th Edition provides you with the up-to-date, authoritative guidance you need to safely and effectively manage patients with chronic renal disease. Covering all relevant clinical management issues, this companion volume to Brenner and Rector?s The Kidney presents the knowledge and expertise of renowned researchers and clinicians in the fields of hemodialysis, peritoneal dialysis, critical care nephrology, and transplantation - for an all-in-one, indispensable guide to every aspect of this fast-changing field.

Numerous examples of attractive natural stone homes.

A comprehensive compilation of modern and innovative prefabricated buildings, also for the price-conscious builders.

The book offers a comprehensive selection of contemporary single-family homes and villas, dream homes in Ibiza

All this is reflected through the pages of this book, which shows a wide range of housing from around the world, of no more than 125 square meters, offering intelligent and ingenious design and construction solutions with a careful aesthetics and with the objective of respecting the environment as much as possible and adapting the environment in which they find themselves.

Most of the projects presented in this book go a step beyond the Existenzminimum, since they represent the application of its precepts in spaces as a rule already existing and of even smaller size. Many of them are experimental prototypes, common in a field such as housing, so prone to formal and functional research.

In this book we have tried to show that it is not only possible, but often the solutions have nothing to envy to the huge lofts of London or Manhattan. A situation that becomes a challenge for the architect, since it requires him to put at stake all his ingenuity, technique and talent, to achieve it: from the use of the height of the roofs to gain space to the luso of glass panels or sliding doors, that allow to obtain diaphanous areas without renouncing, in turn, privacy.

Innovative, practical and extraordinary interior design ideas from all over the world are presented in this beautiful, affordable volume.

Nice selection of modern prefabricated houses, also suitable for the small purse

Attachments, numerous ideas for all sizes. How do I turn a small old house into a modern residential complex?

An opulent selection of modern townhouses from around the world is featured in this beautiful book.

Creative and innovative interior design ideas.

This opulent landscape picture book captivates with its beautiful nature photographs, the representation of the flora and fauna as well as numerous magical and fascinating places on our planet.

Wood like stone, is building material that has been used throughout human history. Western imagery, heir to that of Greece and Rome, has tended to revere stone as mark of nobility and civilization.

A large selection of modern tree houses. From the small hut to the comfortable dwelling spectacular living ideas are shown.

The vast majority of the project in this book are stone-built houses designed to comply with their owners' requirements to have aresidence away from the noise, pollution and stress of the big city.

The book offers a comprehensive selection of contemporary single-family homes and villas

Few things are as stressful and as exciting as moving house. Empty spaces create the same anxiety that an artist suffers in front of a blank canvas. So much to do and so many possibilities!

Beutespuren, fremde Ger�che und bedrohliche Tr�ume ? Feuerherz sp�rt, dass eine neue Gefahr im Wald lauert, doch er kann sie nicht fassen. Hat etwa sein alter Feind Tigerstern die Pfoten im Spiel? Erst in letzter Sekunde erkennt Feuerherz, dass hinter all den seltsamen Ereignissen ein teuflischer Plan steckt ?

Feuerherz hat es geschafft! Er ist der Zweite Anf�hrer des DonnerClans geworden. Doch die Katzen des Clans sind verunsichert und nicht alle akzeptieren Feuerherz? neue Rolle. Auch Blaustern, die Clan-Anf�hrerin, verh�lt sich immer seltsamer. Als der Wald von einer schrecklichen Katastrophe heimgesucht wird, steht Feuerherz vor der schwersten Aufgabe seines Lebens: Wird es ihm gelingen, seinen Clan in ein neues Leben zu f�hren?

�Auch der dritte Band der Warrior Cats begeistert Jungen und M�dchen gleicherma�en.� Wir Eltern �Fantasy der ungew�hnlichen Sorte.� Buchjournal �Man kann sich der spannenden Geschichten um die Clan-Katzen nicht entziehen: Jeder Roman fesselt und l�sst den Leser nicht mehr los.� Abenteuer & Phantastik Die Treue zum eigenen Clan steht f�r die Katzen des Waldes an erster Stelle. Doch gilt das wirklich f�r alle? Der junge Krieger Feuerherz sp�rt, dass sich Unheil im DonnerClan zusammenbraut: Einige Katzen verhalten sich �u�erst r�tselhaft. Er geht der Sache nach und kommt einem gef�hrlichen Geheimnis auf die Spur. Als der DonnerClan Opfer eines heimt�ckischen �berfalls wird, ist endg�ltig klar: Ein Verr�ter muss sich in den Clan eingeschlichen haben. Wem kann Feuerherz jetzt noch trauen?

Herr Taschenbier ist ein �ngstlicher Mensch. Er f�rchtet sich vor seiner Zimmerwirtin, vor seinem Chef und �berhaupt vor allen Leuten, die schimpfen und befehlen - bis ihm eines Samstags ein Sams �ber den Weg l�uft und kurzerhand beschlie�t, bei ihm zu bleiben. Das Sams ist ein furchtloses, ja beinahe respektloses Wesen, das sich von nichts und niemandem einsch�chtern l�sst, das �berall freche Bemerkungen macht und zur�ckschimpft, wenn andere schimpfen. Herrn Taschenbier ist das anfangs furchtbar peinlich und er versucht auf alle m�glichen Arten, das Sams wieder loszuwerden.Aber seltsam: Je l�nger es bei Herrn Taschenbier bleibt, desto lieber gewinnt er das Sams. Und am Schluss wird aus dem braven, �ngstlichen Herrn Taschenbier ein selbstbewusster Mensch, der gelernt hat, sich zu behaupten.

Hexe Lilli reitet f�r ihr Leben gern. Doch f�r den Ausflug ins Gel�nde fehlt es ihr an Erfahrung, meint der Reitlehrer. Deshalb bleibt Lilli allein auf dem Ponyhof zur�ck. Allein? Nicht ganz! Denn im Stall steht ein Shetlandpony, das wohl auch nicht mit durfte. Typisch!, denkt Lilli, und reitet mit ihm auf eigene Faust los. Oje, das wird ein wilder Ritt!�ZAWUSCH, landen die beiden auf den fernen Shetlandinseln und mitten in einem neuen Abenteuer...

Mit ihrem Hexenbuch stellt Lilli alles auf den Kopf! So auch diesmal, als sie auf die Idee kommt, M�rchenfiguren lebendig zu zaubern. Bl�d nur, dass dieser Hans im Gl�ck die Sache mit dem Tauschen nicht kapiert. Was soll Lilli jetzt mit dem Pferd in Omas Wohnung machen?

Mit ihrem Hexenbuch stellt Lilli alles auf den Kopf! So auch diesmal, als Mamas Fahrrad geklaut wird, und Lilli sich mit Detektiv- und Hexentricks auf die Suche nach dem T�ter macht. Ob sie dem ausgekochten Halunken auf die Schliche kommt?

Hilfe, der Schulrat kommt! Hexe Lilli hat die supergeniale Idee, ihrer Lehrerin ein wenig beim Probeunterricht zu helfen. Na, so einen verr�ckten Schultag hat die Klasse noch nicht erlebt!

Kommissar Spaghetti hei�t eigentlich Giacomo Pomeriggio, ist 1,99 m gro�, spindeld�rr, Italiener und Hausmeister mit detektivischen Ambitionen. Sein T�tigkeitsfeld ist die Erich-K�stner-Schule in Lummelsbach. Er ist ein Freund der Kinder - besonders wenn es darum geht, Isabella Nothnagel, ihres Zeichens Rektorin, Paroli zu bieten. Ein Schwein im Lehrerzimmer? Auf dem Platz der Rektorin? Das geht zu weit.

Madrid Muzeul del Prado este unul dintre cele mai mari muzee din lume, colec?iile sale includ aproximativ 8.000 de picturi, 5.000 de desene, 2.000 de grafic?, 700 de sculpturi ?i 2.000 de alte opere de art?. Nu exist? o colec?ie comparabil? de pictur? clasic? spaniol?, ?i exist?, de asemenea, capodopere din alte ??ri care sunt renumite �n lume, deoarece acestea au fost permanent inscrip?ionate �n istoria artei occidentale. Printre acestea se num?r? exemple de pictur? din tab?ra renascentist? din nordul Europei, picturi baroc flamande, capodopere italiene create �ntre secolele XV-XVIII ?i operele care reprezint? clasicismul francez ?i olandez.

Toate lucr?rile de art? prezentate aici au un lucru �n comun - provin din Africa. Nu ?tim aproape nimic despre creatorii lor. ?n c?l?toria prin spa?iu ?i timp, contextul �n care ne uit?m la ele sa schimbat, �mpreun? cu acesta ?i-a schimbat semnifica?ia. Acest album v? ofer? o perspectiv? asupra lumii fascinante a artei africane. Albumul con?ine peste 300 de fotografii de obiecte extraordinare create din Guineea-Bissau �n Mozambic.

Maria Sibylla Merian (1647-1717) a ocupat o pozi?ie special? at�t �n lumea ?tiin?ific?, c�t ?i �n cea artistic?. Ea a fost unul dintre pionierii entomologiei. Ea a fost un artist excep?ional ?i cercet?tor, descoperitor. Picturile ei de flori, fluturi ?i alte insecte, pe care le-a cercetat �n Europa ?i �n timpul unei excursii �n Surinam, �nc? �nc�ntau frumuse?ea ?i cantitatea de detalii. Albumul con?ine peste 70 de reproduceri de lucr?ri �ntr-un format mare.

Art Nouveau: elegant ornamentation and sensual women. Hardly any artist proved a greater vituoso in this style than Alphonse Mucha. Discover not only the most beautiful of the Czech artist's posters, butalso many of lesser-known works such asoil paintings, furniture, interior design, and murals.

His Great Wave off Kanagawa is the most famous work in East Asian art. Hokusai, a self-confessed eccentric obsessed with art, created with his pictures of the floating world veritable encyclopedia of Japanese daily life and thus became a major source for Europeans seeking to understand the art and culture of Japan.

Paul Gaugin was the leader of the Pont-Aven school, and one of the most important post-impressionist painters. His aesthetic reasarches took him to Brittany before lurning him to the Pacific isles on a quest for a lost paradise and a wild nature. His influence on modern painting was to be decisive.

Vincent van Gogh (1853-1890) is one of the most famous artists of all time and his paintings are an indelible part of a worldwide pictorial memory. His sunflowers, starry nights and night caf�s adorn countless living rooms around the globe. A meteoric rise, considering that he sold only one painting during his lifetime, whereas his paintings are now guaranteed to make tens of millions at auctions today.