Stereotactic Radiosurgery and Stereotactic Body Radiation Therap

Description:

This book is a comprehensive review of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT): its physics, clinical evidence, indications, and future directions. The utilization of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) is increasing internationally because of several factors. First, it offers patients a local treatment option that has demonstrated effectiveness similar to traditional surgery without the morbidity of general anesthesia and open surgical resection. Second, recent advancements in the quality of scientific evidence supporting a SRS or SBRT-containing approach in patients continues to evolve and demonstrate favorable disease-specific outcomes with little, if any, toxicity in various anatomic disease sites and for various conditions including cancer, benign tumors, and other psychiatric and neurologic conditions. Third, and most provocatively, is the notion that definitive local therapy (i.e. SRS or SBRT) in patients with cancer can boost the immune system to fight cancer in other sites throughout the body. While traditional medical knowledge would suggest that all patients with metastatic cancer are incurable, there is a mounting body of evidence that there is a subset of these patients that can be cured with definitive SRS or SBRT. This volume thus delves into each of these benefits and aspects of treatment, guiding physicians to the best treatment plan for their patients. Expert, international authors provide guidelines for SRS and SBRT use by clinicians. Chapters are divided into six main sections: Radiobiology of Radiosurgery and Stereotactic Body Radiation Therapy, Intracranial  Radiosurgery Technique, Intracranial Radiosurgery by Indication, Stereotactic Body Radiation Therapy Technique, Stereotactic Body Radiation Therapy by Indication, The Future of Radiosurgery and SBRT. Overall physics are explained, as well as specific considerations for particular surgical tools (including the Leksell Gamma Knife and Accuray CyberKnife), techniques (including fractionated and charged particle radiosurgery), and anatomic sites (including brain metastases, pituitary tumors, and the prostate). Detailed images and charts enhance the chapters. This book provides physicians with a single, practical resource incorporating both of these broad categories of treatment, SRS and SBRT, and better defines the current role and the direction of radiosurgery.

Table of Contents:

Part I. Radiobiology of Radiosurgery and Stereotactic Body Radiation Therapy

Vascular-Mediated Mechanisms and SRS/SBRT

Radio-Immunology of Ablative Radiation

Rationale for Fractionated SRS and Single SRS Session Approaches

Part II. Intracranial Radiosurgery Technique

Physics of Radiosurgery

Leksell Gamma Knife Radiosurgery

CyberKnife Robotic Stereotactic Radiosurgery

Linear Accelerator-Based Radiosurgery: Technique

Fractionated Radiosurgery

Charged-Particle Proton Radiosurgery

Part III. Intracranial Radiosurgery by Indication

Stereotactic Radiosurgery for Brain Metastases

Stereotactic Radiosurgery for Pituitary Adenoma

Stereotactic Radiosurgery for Meningioma

Stereotactic Radiosurgery for Intracranial Arteriovenous Malformations

Radiosurgical Management of Trigeminal Neuralgia

Radiosurgery for Vestibular Schwannomas

Stereotactic Radiosurgery for Glial Tumors

Part IV. Stereotactic Body Radiation Therapy Technique

Physics of Stereotactic Body Radiotherapy

Immobilization for SBRT: A Crucial Prerequisite Toward Accurate Treatment

Motion Management in Stereotactic Body Radiation Therapy

Charged Particle Stereotactic Body Radiation Therapy

Part V. Stereotactic Body Radiation Therapy by Indication

Stereotactic Body Radiation Therapy (SBRT) for Primary Lung Cancer

Stereotactic Body Radiation Therapy (SBRT) for Lung Metastases

Stereotactic Body Radiation Therapy (SBRT) for Spinal Tumors

Stereotactic Body Radiation Therapy for Gastrointestinal Cancers

SAbR for Primary Prostate Cancer

Stereotactic Ablative Radiotherapy (SAbR) for Primary Renal Cell Carcinoma

Head and Neck Stereotactic Body Radiation Therapy

Pediatric Radiosurgery

Part VI. The Future of Radiosurgery and SBRT

Patient Selection in SBRT and SRS

SRS and SBRT Complications and Management

SRS and SBRT Integration with Supportive Care

Targeted Agents and Immunotherapy

Diagnostic Imaging Advances

Comparative Effectiveness of SBRT

Back Matter