Pharmaceutical Biotechnology: A Focus on Industrial Application

Description:

Pharmaceutical Biotechnology: A Focus on Industrial Application covers the development of new biopharmaceuticals as well as the improvement of those being produced. The main purpose is to provide background and concepts related to pharmaceutical biotechnology, together with an industrial perspective. This is a comprehensive text for undergraduates, graduates and academics in biochemistry, pharmacology and biopharmaceutics, as well as professionals working on the interdisciplinary field of pharmaceutical biotechnology. Written with educators in mind, this book provides teachers with background material to enhance their classes and offers students and other readers an easy-to-read text that examines the step-by-step stages of the development of new biopharmaceuticals. Features: Discusses specific points of great current relevance in relation to new processes as well as traditional processes Addresses the main unitary operations used in the biopharmaceutical industry such as upstream and downstream Includes chapters that allow a broad evaluation of the production process Dr. Adalberto Pessoa Jr. is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo and Visiting Senior Professor at King’s College London. He has experience in enzyme and fermentation technology and in the purification processes of biotechnological products such as liquid–liquid extraction, cross-flow filtration and chromatography of interest to the pharmaceutical and food industries. Dr. Michele Vitolo is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo. He has experience in enzyme technology, in immobilization techniques (aiming the reuse of the biocatalyst) and in the operation of membrane reactors for obtaining biotechnological products of interest to the pharmaceutical, chemical and food industries. Dr. Paul F. Long is Professor of Biotechnology at King's College London and Visiting International Research Professor at the University of São Paulo. He is a microbiologist by training and his research uses a combination of bioinformatics, laboratory and field studies to discover new medicines from nature, particularly from the marine environment.

Table of Contents:

Chapter 1 Fundamentals of Biotechnology

Chapter 2 Thermodynamics Applied to Biomolecules

Chapter 3 Expression Systems for the Production of Therapeutic Recombinant Proteins

Chapter 4 Molecular Biology: Tools in Industrial Pharmaceutical Biotechnology

Chapter 5 Molecular Biology Tools: Techniques and Enzymes

Chapter 6 Bioinformatics Applied to the Development of Biomolecules of Pharmaceutical Interest

Chapter 7 Bioprocesses: Microorganisms and Culture Media

Chapter 8 Sterilization in Pharmaceutical Biotechnology

Chapter 9 Kinetics of Cell Cultivation

Chapter 10 Bioreactors: Modes of Operation

Chapter 11 Agitation and Aeration: Oxygen Transfer and Cell Respiration

Chapter 12 Mammalian Cell Culture Technology

Chapter 13 Purification Process of Biomolecules

Chapter 14 Lipopolysaccharides: Methods of Quantification and Removal from Biotechnological Products

Chapter 15 Enzymes: The Catalytic Proteins

Chapter 16 Enzymes as Drugs and Medicines

Chapter 17 Aspects of the Immobilization Technique

Chapter 18 Biomolecules in Analytical Methods

Chapter 19 Nanotechnology and Biopharmaceuticals

Chapter 20 Biosafety Applied in Pharmaceutical and Biotechnological Processes

Chapter 21 Pharmaceutical Quality System for Biotechnology Products

Chapter 22 Techno-Economic Evaluation of Biotechnological Processes and Pharmacoeconomic Analysis

Chapter 23 Perspectives for Pharmaceutical Biotechnology

Index