Male Infertility, 1st Edition

Description: Despite the fact that about half of infertility problems stem from male factors, gynecologists are often the first health care providers to perform the initial assessment of the infertile couple. For this reason, it is critical that gynecologists and reproductive medicine specialists remain up to date on the primary conditions that cause male infertility, as well as current diagnostic tools and treatment options of both natural and assisted conception. From diagnosis through treatment, Male Infertility: Management of Infertile Men in Reproductive Medicine offers expert, straightforward guidance on the pathophysiology and management of male infertility for clinicians who assist couples early in the process of trying to conceive.

Features:

Covers diagnostic aspects of male infertility (clinical, laboratory, and imaging methods) as well as various therapeutic options including classical and advanced surgical procedures. Discusses intrauterine insemination, conventional in vitro fertilization, intracytoplasmic sperm injection, sperm cryopreservation, preimplantation genetic testing, and more. Begins each chapter with key points and ends with clinical scenarios of real-life problems and their solutions. Shares the knowledge and expertise of global experts in the field. An digital version is included with purchase. The digital allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Table of Contents:

 

SECTION 1. Definition, Epidemiology, and Implications of Male Infertility

1.  Definition, epidemiology, and implications of male infertility

Introduction

Epidemiology of male infertility

Health implications of male infertility

Summary

References

SECTION 2. Causes of Male Infertility

2.  Pretesticular causes of male infertility

Introduction

Physiopathology of the hypothalamic-pituitary-gonadal axis

Clinical picture and diagnosis

Etiologies of hypogonadotropic hypogonadism

Medical treatment of hypogonadotropic hypogonadism

Clinical case scenarios

Summary

References

3.  Testicular causes of male infertility

Introduction

Congenital causes of male infertility

Genetic causes

Infective causes

Disorders of spermatogenesis

Testicular tumors

Trauma to the testis

Torsion of the testis

Testicular microcalcifications

Cell phone radiation

Heat exposure

Secondary testicular causes of male infertility

Management of testicular causes of male infertility

Treatment

Clinical case scenarios

Summary

References

4.  Posttesticular causes of male infertility

Introduction

Posttesticular causes of male infertility

Clinical scenarios

Summary

References

5.  Environmental/lifestyle factors and male infertility

Introduction

Environmental/occupational factors and male infertility

Summary

References

6.  Idiopathic male infertility

Introduction

Etiology and prevailing theories

Diagnosis of idiopathic male infertility

Treatment of idiopathic male infertility

Summary

References

SECTION 3. Diagnosis of Male Infertility

7.  Medical history and physical examination of infertile males

Introduction

History

Physical examination

Telehealth and male infertility assessment

Summary

References

8.  Basic semen analysis

Introduction

Basic semen examination—changes in the world health organization manual, 6th edition

Reference values

Conclusion

Summary

References

9.  Sperm DNA fragmentation tests

Introduction

Sperm DNA structure

Types of sperm DNA fragmentation

DNA repair

Causes of sperm DNA fragmentation

Impact of SDF on reproductive outcomes

Terminal deoxynucleotidyl transferase dUTP nick-end labeling assay

Sperm chromatin structure assay

Sperm chromatin dispersion test

Comet assay (single-cell gel electrophoresis)

Current recommendations of sperm DNA fragmentation testing by professional societies

Challenges of sperm DNA fragmentation testing in clinical practice

Clinical scenarios

Summary

References

10.  Genetic and genomic tests of infertile males

Introduction

Genetic tests

Genomic tests

Clinical/laboratory scenarios

Summary

Funding

References

11.  Computer-assisted semen analysis

Introduction

Description of different types of computed-assisted semen analysis systems

Semen examinations using computer-assisted semen analysis

Recommendations, advantages, and disadvantages of computer-assisted semen analysis systems

Perspectives and emerging technologies

Summary

References

12.  Seminal oxidative stress and reactive oxygen species testing

Introduction

Sources of reactive oxygen species in the male reproductive tract

Antioxidant regulation of reactive oxygen species in the male reproductive tract

Physiological role of reactive oxygen species in male reproduction and fertility

Pathological effects of oxidative stress in male reproduction

Seminal biomarkers of reactive oxygen species and oxidative stress

Summary

References

13.  Assessment of reproductive hormones in infertile males

Introduction

Gonadotropins

Testosterone and testicular androgens

The human spermatogenesis

Pretesticular causes: The hypothalamus-pituitary-gonadal axis

Testicular causes: Primary testicular failure

Laboratory assessment

Clinical case scenarios

Summary

References

14.  Imaging in male factor infertility

Introduction

Male reproductive gross anatomy

Basic principles of ultrasonography

Basic principles of computed tomography

Basic principles of magnetic resonance imaging

Testis imaging

Epididymis imaging

Vas deferens imaging

Seminal vesicle and ejaculatory duct imaging

Summary

References

SECTION 4. Medical Treatment of Male Infertility

15.  Hormonal therapy of male infertility

Introduction

Hormonal therapy of infertile males

Clinical case scenarios

Summary

References

16.  Antioxidants therapy of male infertility

Introduction

Protective action of antioxidants

Impact of antioxidant therapy of infertile males on semen parameters

Impact of antioxidant therapy of infertile males on pregnancy outcomes

Practice patterns of the use of antioxidant therapy in male infertility

Professional societies’ guidelines of antioxidant therapy in male infertility

Limitations of antioxidant therapy in male infertility

Summary

References

17.  Antibiotic therapy of male infertility

Introduction

Semen and testicular microbiomes

Seminal microbiome and assisted reproductive technique outcome

Diagnosis of genital tract infection

Impact of leukocytospermia on male fertility

Antibiotics therapy of male infertility

Overview of the current guidelines

Antibiotics as adjuvants in assisted reproductive technique

Clinical case scenarios

Antibiotic alternatives

Summary

References

18.  Alternative therapy of male infertility

Introduction

Nutrition and male fertility

Malnutrition/nutrient deficiencies and male infertility

Herbal treatment for male infertility

Herbs with positive effects on sperm quality

Herbs with negative effects on sperm quality

Physical exercise and male fertility

The positive impact of exercise on male fertility

The negative impact of exercise on male fertility

Psychological and behavioral therapy

Effects of psychological stress on reproductive function

Treatment of psychological stress–related disease

Clinical/laboratory case scenario

Summary

References

SECTION 5. Surgical Treatment of Male Infertility

19.  Varicocele repair in infertile males

Introduction

Pathogenesis of varicocele

Diagnosis and grading of varicocele

Impact of varicocele on male fertility

Society guidelines

Types of intervention

Outcomes of intervention

Complications of varicocelectomy

Summary

Clinical case scenarios

References

20.  Management of ejaculatory duct obstruction

Introduction

Epidemiology of obstruction of male reproductive tract

Anatomical considerations

Functional considerations

Etiology and pathophysiology of ejaculatory duct obstruction

Evaluation of ejaculatory duct obstruction

Differential diagnosis of ejaculatory duct obstruction

Treatment of ejaculatory duct obstruction

Clinical case scenario

Summary

References

21.  Surgical sperm retrieval and processing for assisted reproductive technology

Introduction

Narrative review

Summary

References

SECTION 6. Assisted Reproduction

22.  Intrauterine insemination with homologous semen

Introduction

Diagnostic work-up before intrauterine insemination and when to start with intrauterine insemination

Indications for intrauterine insemination with partner semen

Factors influencing intrauterine insemination outcome

Perinatal outcome after intrauterine insemination/prevention of multiple pregnancies

Cost effectiveness of intrauterine insemination

Summary

References

23.  In vitro fertilization/intracytoplasmic sperm injection

Introduction

Indications for in vitro fertilization

Current technique of in vitro fertilization

Improvements in in vitro fertilization techniques over the past 30 years

Advances of intracytoplasmic sperm injection—improvements over the last 30 years

Clinical case scenarios

Summary

References

24.  Techniques for selection of surgically retrieved sp erm for intracytoplasmic sperm injection

Introduction

Surgically retrieved sperm selection

Sperm selection methods

Intracytoplasmic morphologically selected sperm injection

Microfluidics-based sperm selection techniques

Clinical case scenarios

Summary

References

25.  Sperm banking

Introduction

Indications of sperm cryopreservation

Sperm cryopreservation

Assisted reproductive technique outcomes with frozen donor sperm

Emergence of field of oncofertility and its importance in assisted reproductive technique

Management of cryobanking services and facilities

General requirements for sperm banking

Conclusions

Summary

References

SECTION 7. Clinical Practice Guidelines for Male Infertility

26.  Guidelines of the American society for reproductive medicine, American urological association, and European association of urology

Introduction

Causes and risk factors of male infertility

Diagnosis of male infertility

Management of male infertility before the assisted reproductive technology stage

Male infertility management with assisted reproductive techniques

Clinical/laboratory case scenario

Summary

References

27.  Expert opinion: Management of male infertility in the postintracytoplasmic sperm injection era

Introduction

The importance of evaluating and treating male infertility

Controversies in evaluation of an infertile male

Conclusion

Summary

References

SECTION 8. Insights Into the Future of Male Infertility

28.  Clinical perspective in the postintracyoplasmic sperm injection era

Introduction

Role of epigenetics in the management of male infertility

Role of proteomics in the management of male infertility

Optimizing sperm selection techniques for intracytoplasmic sperm injection

Molecular markers for predicting sperm retrieval in nonobstructive azoospermia

The future of stem cell therapy in male infertility

Fertility preservation in cancer patients

Role of artificial intelligence in the practice of male infertility

Summary

References

29.  Research perspectives in the postintracytoplasmic sperm injection era

Introduction

New developments in androurological diagnostics

Utility of artificial intelligence in reproductive medicine

Applications of stem cell research in male fertility preservation

Summary

References

Index

 

 

An aparitie	15 mar 2024
Autor	Ashok Agarwal, Florence Boitrelle, Panagiotis Drakopoulos, Hassan Nooman Sallam, Ramadan Saleh
Editura	Elsevier
Format	Paperback
ISBN	9780323930475
Limba	Engleza
Nr pag	352
Versiune digitala	DA