Endocrinology of the Heart in Health and Disease

Endocrinology of the Heart in Health and Disease

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Cod produs/ISBN: 9780128031117

Disponibilitate: La comanda in aproximativ 4 saptamani

Editura: Elsevier

Limba: Engleza

Nr. pagini: 378

Coperta: Hardcover

Dimensiuni: 216 x 276 x 23 mm

An aparitie: 11 Nov 2016



  • Develops the concept of the heart as both an endocrine organ and an endocrine target, exploring the endocrine function of the heart in both health and disease
  • Explains how the levels of several cardiac hormones are changed in various cardiac pathologies and how some hormones can be used therapeutically
  • Offers a single resource on cardio-endocrine disease which collates and curates the wide range of advances being made in the areas of molecular biology, biochemistry, physiology, and pathology

Table Of Contents:

  • Dedication
  • List of Contributors
  • Foreword
  • Preface
    • The Heart as an Endocrine Organ
    • The Heart as an Endocrine Target
  • Acknowledgments
  • Part I: The Heart as an Endocrine Organ
    • Chapter 1. Cardiac Natriuretic Peptides
      • Abstract
      • Historical Perspective
      • Gene Structure of Natriuretic Peptides
      • Translation, Processing, and Storage of Cardiac Natriuretic Peptides
      • Circulating Concentrations, Forms, and Metabolism of Natriuretic Peptides
      • Circulating Natriuretic Peptide Signal Peptides
      • Assays Measuring Natriuretic Peptides in the Circulation
      • Bioactivity
      • Natriuretic Peptide as Therapeutic Agents
      • Enhancing Bioactivity
      • Natriuretic Peptides as Biomarkers in Heart Failure
      • References
    • Chapter 2. Adrenomedullin
      • Abstract
      • Introduction
      • Molecular Forms, Structure, and Structure-Activity Relationships of Adrenomedullin
      • The Adrenomedullin Receptor
      • Cardiac Actions of Adrenomedullin
      • Pathophysiological Function of Adrenomedullin in Cardiac Disease
      • Clinical Applications of Adrenomedullin to Cardiac Disease
      • Conclusion
      • References
    • Chapter 3. Endothelin-1 as a Cardiac-Derived Autocrine, Paracrine and Intracrine Factor in Heart Health and Disease
      • Abstract
      • Introduction
      • Cardiac Production of ET-1
      • Cardiac ET-1 Production in Heart Disease
      • Expression of Cardiac ET Receptors
      • Cardiac Effects of ET-1
      • Physiological and Pathophysiological Roles of Cardiac-Derived ET-1: General Concepts
      • Potential Beneficial Effects of ET-1 in Cardiac Function
      • Development of Clinical Strategies aimed at Targeting ET-1
      • Clinical Evaluation of ET Receptor Antagonists for Treating Heart Disease
      • Concluding Comments
      • Acknowledgements
      • References
    • Chapter 4. The Cardiokines: An Expanding Family of the Heart Secretome
      • Abstract
      • Introduction
      • Cellular Components of the Heart Involved in the Cardiac Secretome
      • The Autocrine, Paracrine, and Endocrine Heart: Components of the Cardiac Secretome
      • Growth Factor Generation in the Heart
      • Inflammatory Mediators Generated in the Heart
      • Cardiac Exosomes and miRNA
      • Insight into Future Directions
      • Acknowledgement
      • References
    • Chapter 5. Novel Small Peptide Hormones
      • Abstract
      • Introduction
      • Endocrine Factors Regulating Blood Pressure and Cardiac Function: Neuronostatin and Adropin
      • Novel Adipokines in the Control of Cardiovascular Function: Nesfatin-1 and Omentin
      • Role of Myokines in Cardiovascular Health: Irisin
      • Modulatory Peptides Encoded by Upstream Short Open Reading Frames of Hormone Receptors: PEP7
      • Summary and Conclusions
      • References
  • Part II: The Heart as an Endocrine Target
    • Chapter 6. Gut-Derived Hormones—Cardiac Effects of Ghrelin and Glucagon-Like Peptide-1
      • Abstract
      • Ghrelin
      • Glucagon-Like Peptide-1
      • References
    • Chapter 7. Fat Hormones, Adipokines
      • Abstract
      • Introduction
      • Obesity as a Chronic Proinflammatory State
      • Proinflammatory Adipokines
      • Anti-Inflammatory Adipokines
      • Conclusion
      • References
    • Chapter 8. Neuronal Hormones and the Sympathetic/Parasympathetic Regulation of the Heart
      • Abstract
      • Introduction
      • Electrical System of the Heart
      • Sympathetic Nervous System of the Heart
      • Concluding Remarks
      • References
    • Chapter 9. Renin Angiotensin Aldosterone System and Heart Function
      • Abstract
      • The Conventional Renin Angiotensin Aldosterone System
      • RAAS and Heart Cell Communication
      • AT1 Receptor as a Mechanosensor
      • Role of ACE Inhibitors and AT1 Receptor Blockers
      • ACE2/Ang (1-7) /Mas Receptor Axis Activation
      • Local Cardiac RAAS, the Intracrine Component
      • Intracellular Renin Alters Chemical Communication and Metabolic Cooperation
      • Mitochondria, the Nucleus and the Intracrine Renin-Angiotensin System
      • Aldosterone and Mineralocorticoid Receptor
      • New Developments
      • References
    • Chapter 10. Nuclear Receptors and the Adaptive Response of the Heart
      • Abstract
      • Nuclear Receptors: Introduction
      • PGC Coactivators in the Developing and Diseased Heart
      • Estrogen Receptors
      • Estrogen-Related Receptors
      • Glucocorticoid Receptors
      • Mineralocorticoid Receptors
      • Thyroid Hormone Receptors
      • PPAR Family Receptors
      • Emerging and Associated Players
      • Summary
      • References
    • Chapter 11. Adrenergic Receptors
      • Abstract
      • Adrenergic Signaling: Systematic and Updated Overview
      • Sympathetic System and Hypertension
      • Adrenergic Signaling in Heart Failure
      • Pharmacology of Adrenergic Receptor Blockade
      • References
    • Chapter 12. Insulin Signaling in Cardiac Health and Disease
      • Abstract
      • Abbreviations
      • Introduction
      • Functional Importance of Insulin Receptor Signaling in the Heart
      • Metabolic Effects of Insulin Signaling in the Myocardium
      • Cardiac Insulin Signaling During Obesity and Type 2 Diabetes
      • Insulin Signaling and Cardiac Hypertrophy
      • Cardio-Protective Role of Insulin Signaling in Ischemia Reperfusion and Contractile Failure
      • Scope and Future Perspectives
      • References
  • Index


An aparitie 11 Nov 2016
Autor Jonathan C. Schisler, Charles H Lang, Monte Willis
Dimensiuni 216 x 276 x 23 mm
Editura Elsevier
Format Hardcover
ISBN 9780128031117
Limba Engleza
Nr pag 378

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