Lanzkowsky's Manual of Pediatric Hematology and Oncology

Lanzkowsky's Manual of Pediatric Hematology and Oncology

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Cod produs/ISBN: 9780128013687

Disponibilitate: Acest produs nu este momentan in stoc

Editura: Elsevier

Limba: Engleza

Nr. pagini: 788

Coperta: Hardback

Dimensiuni: 22,4 x 4,3 x 27,7 cm

An aparitie: 2016

Features:

          Presents a concise, systematic approach to all pediatric hematologic and oncologic disorders in one manual

Offers an alternative to bigger references which only cover either oncologic or hematologic disorders in twice as many pages

Presents an easy-to-read format: multiple tables, charts, and flow-diagrams for diagnosis and management of pediatric hematologic and oncologic disorders

Includes 2 new chapters and several expanded chapters: Diagnostic, Molecular and Genomic Methodologies for the Hematologist, Transfusion Medicine, Myelodysplasia, Myeloid Leukemias, and Lymphoid Leukemias

 

Table Of Contents:

 

Dedication

List of Contributors

About the Editors

Preface to the Sixth Edition

Preface to the Fifth Edition

Preface to the Fourth Edition

Preface to the Third Edition

Preface to the Second Edition

Preface to the First Edition

Introduction: Historic Perspective

Reflection on 60 Years of Progress in Pediatric Hematology-Oncology

 

Chapter 1. Diagnostic Molecular and Genomic Methodologies for the Hematologist/Oncologist

Abstract

Clinical Molecular and Genomic Methodologies

Interpreting and Evaluating the Results from Clinical Genetic Testing

Further Reading and References

Chapter 2. Hematologic Manifestations of Systemic Illness

Abstract

Hematologic Manifestations of Diseases Related to Various Organs

Chronic Illness

Lead Intoxication

Nutritional Disorders

Bone Marrow Infiltration

Further Reading and References

Chapter 3. Classification and Diagnosis of Anemia in Children

Abstract

Classification and Diagnosis

Further Reading and References

Chapter 4. Lymphadenopathy and Diseases of the Spleen

Abstract

Lymphadenopathy

Diseases of the Spleen

Splenomegaly

Further Reading and References

Chapter 5. Anemia During the Neonatal Period

Abstract

Hemorrhage

Hemolytic Anemia

Failure of Red Cell Production

Anemia of Prematurity

Physiologic Anemia

Diagnostic Approach to Anemia in the Newborn

Further Reading and References

Chapter 6. Iron-Deficiency Anemia

Abstract

Prevalence

Etiologic Factors

Clinical Features

Diagnosis

Stages of Iron Depletion

Differential Diagnosis

Treatment

Further Reading and References

Chapter 7. Megaloblastic Anemia

Abstract

Vitamin B12 (Cobalamin) Deficiency

Folic Acid Deficiency

Clinical Features of Cobalamin and Folate Deficiency

Diagnosis of Cobalamin and Folate Deficiency

Treatment

Further Reading and References

Chapter 8. Bone Marrow Failure

Abstract

Aplastic Anemia

Acquired Aplastic Anemia

Inherited Bone Marrow Failure Syndromes

Fanconi Anemia

Dyskeratosis Congenita

Congenital Aplastic Anemias of Unknown Inheritance

Diamond–Blackfan Anemia (Congenital Pure Red Cell Aplasia)

Transient Erythroblastopenia of Childhood

Congenital Dyserythropoietic Anemia

Sideroblastic Anemias (Mitochondrial Diseases with Bone Marrow Failure Syndromes)

Severe Congenital Neutropenia and Kostmann Syndrome

Reticular Dysgenesis

Further Reading and References

Chapter 9. General Considerations of Hemolytic Diseases, Red Cell Membrane, and Enzyme Defects

Abstract

Clinical Features of Hemolytic Disease

Laboratory Findings

Membrane Defects

Paroxysmal Nocturnal Hemoglobinuria

Enzyme Defects

Further Reading and References

Chapter 10. Extracorpuscular Hemolytic Anemia

Abstract

Immune Hemolytic Anemia

NonImmune Hemolytic Anemia

Further Reading and References

Chapter 11. Hemoglobinopathies

Abstract

Sickle Cell Disease

Thalassemias

Management of the Acutely Ill Thalassemic Patient

Further Reading and References

Chapter 12. Polycythemia

Abstract

Polycythemia (Erythrocytosis) in the Newborn

Polycythemia in Childhood

Polycythemia Vera

Primary Familial and Congenital Polycythemia

Congenital Polycythemia Due to Altered Hypoxia Sensing with Normal P50

Congenital Polycythemia Due to Altered Hypoxia Sensing with Decreased P50

Other Causes of Polycythemia

Diagnostic Approach

Further Reading and References

Chapter 13. Disorders of White Blood Cells

Abstract

Quantitative Disorders of Leukocytes

Decreased Production or Intrinsic Defects of Neutrophils

Increased Destruction or Extrinsic Defects of Neutrophils

Immune Neutropenia

NonImmune Neutropenia

Eosinophils

Lymphocytes

Disorders of Leukocyte Function

Disorders of Adhesion and Chemotaxis

Disorders of Neutrophil Granules

Disorders of Oxidative Metabolism

Neutrophil Production and Destruction in Newborn Infants

Neutrophil Function in the Newborn

Further Reading and References

Chapter 14. Disorders of Platelets

Abstract

Thrombocytopenia in the Newborn

Inherited Thrombocytopenias

Immune Thrombocytopenic Purpura (ITP)

Other Causes of Thrombocytopenia

Thrombocytosis

Qualitative Platelet Disorders

Acquired Platelet Disorders

Nonthrombocytopenic Purpura

Further Reading and References

Chapter 15. Disorders of Coagulation

Abstract

Hemostatic Disorders

Hemostasis in the Newborn

Detection of Hemostatic Defects

Acquired Coagulation Factor Disorders

Inherited Coagulation Factor Disorders

von Willebrand Disease

Rare Coagulation Factor Disorders (FII, V, VII, X, XI, XIII, Fibrinogen Deficiencies)

Thrombotic Disorders

Venous Thrombosis

Arterial Thrombosis

Antiphospholipid Antibody Syndrome

Hereditary Thrombotic Disorders

Thrombotic Disorders in Newborns

Antithrombotic Agents

Antithrombotic Therapy in Special Conditions

Further Reading and References

Chapter 16. Lymphoproliferative Disorders

Abstract

Lymphoproliferative Disorders

Further Reading and References

Chapter 17. Myelodysplastic Syndromes and Myeloproliferative Disorders

Abstract

Myelodysplastic Syndromes

Juvenile Myelomonocytic Leukemia

Myeloproliferative Neoplasms

CML, BCR–ABL1 Positive

Essential Thrombocythemia and Polycythemia Vera

Primary Myelofibrosis

Further Reading and References

Chapter 18. Acute Lymphoblastic Leukemia

Abstract

Incidence of ALL

Etiology

Clinical Features of ALL

Prognostic Factors

Treatment

Infant Leukemia

Philadelphia-Positive ALL

Down Syndrome and ALL

Relapse in Children with ALL

Future Drugs in ALL Therapy

Further Reading and References

Chapter 19. Acute Myeloid Leukemia

Abstract

Incidence and Epidemiology

Etiology and Predisposing Conditions

Clinical Features

Diagnosis

Classification of AML

Treatment

Novel Therapeutic Approaches

Acute Promyelocytic Leukemia

AML Special Subgroups

Further Reading and References

Chapter 20. Histiocytosis Syndromes

Abstract

Langerhans Cell Histiocytosis

Other Histiocytic Disorders

Macrophage Mediated Disorders

Further Reading and References

Chapter 21. Hodgkin Lymphoma

Abstract

Etiology and Epidemiology

Risk Factors

Biology

Pathology

Clinical Presentation

Diagnostic Evaluation and Staging

Prognostic Factors

Treatment

Long-Term Complications

Follow-Up Evaluations

Further Reading and References

Chapter 22. Non-Hodgkin Lymphoma

Abstract

Introduction

Incidence and Epidemiology

Pathologic Classification

Clinical Features

Diagnosis

Staging

Prognosis

Management

Lymphoblastic Lymphoma

B Lineage NHL

Further Reading and References

Chapter 23. Central Nervous System Malignancies

Abstract

Epidemiology

Pathology

Clinical Manifestations

Genetic Syndromes Associated with Pediatric Brain Tumors

Diagnostic Evaluation

Treatment

Astrocytomas

Medulloblastoma

Relapsed Medulloblastoma

Brain Stem Tumors

Ependymomas

Optic Glioma

Craniopharyngiomas

Intracranial Germ Cell Tumors

Malignant Brain Tumors in Infants and Children Less Than 3 Years of Age

Further Reading and References

Chapter 24. Neuroblastoma

Abstract

Epidemiology

Predisposition

Pathology and Biology

Clinical Features

Diagnosis and Staging

Treatment

Prognosis, Risk Stratification, and Therapy

Post-Therapy Monitoring

Special Treatment Considerations

Neuroblastoma in the Adolescent and Young Adult

Further Reading and References

Chapter 25. Renal Tumors

Abstract

Wilms’ Tumor

Nephroblastomatosis

Congenital Mesoblastic Nephroma

Clear Cell Sarcoma of the Kidney

Rhabdoid Tumor of the Kidney

Renal Cell Carcinoma

Further Reading and References

Chapter 26. Rhabdomyosarcoma and Other Soft-Tissue Sarcomas

Abstract

Incidence and Epidemiology

Pathologic and Genetic Classification

Clinical Features

Diagnostic Evaluation

Staging

Prognosis

Treatment

Follow-Up After Completion of Therapy

Recurrent Disease

Future Perspectives

Further Reading and References

Chapter 27. Malignant Bone Tumors

Abstract

Osteosarcoma

Ewing Sarcoma Family of Tumors

Other Bone Tumors

Further Reading and References

Chapter 28. Retinoblastoma

Abstract

Incidence

Classification

13q Deletion Syndrome

Risk for Second Malignant Neoplasms

Pathology

Clinical Features

Diagnostic Procedures

Treatment

Posttreatment Management

Future Perspectives

Further Reading and References

Chapter 29. Germ Cell Tumors

Abstract

Incidence

Pathology

Clinical Features

Diagnostic Evaluation

Tumor Markers

Staging

Treatment

Further Reading and References

Chapter 30. Hepatic Tumors

Abstract

Incidence

Epidemiology

Pathology

Clinical Features

Diagnostic Evaluation

Staging

Treatment

Follow-up

Prognosis

Further Reading and References

Chapter 31. Hematopoietic Stem Cell Transplantation

Abstract

Allogeneic Stem Cell Transplantation

HSC Sources, Collection, and Manipulation

Engraftment

Complications of HSCT

Late Sequelae of Stem Cell Transplantation

Further Reading and References

Chapter 32. Management of Oncologic Emergencies

Abstract

Metabolic Emergencies

Cardiothoracic Emergencies

Abdominal Emergencies

Renal Emergencies

Neurologic Emergencies

Endocrine Emergencies

Treatment-Associated Emergencies

Further Reading and References

Chapter 33. Supportive Care of Patients with Cancer

Abstract

Management of Infectious Complications

Infection Prophylaxis

Recognition and Management of Nausea and Vomiting

Mucositis

Pain Management

Nutritional Status of the Oncology Patient

Utilization of Hematopoietic Growth Factors

Management of Acute Radiation Side Effects

Management of CVCs

Posttreatment Immunizations

Palliative Care

Further Reading and References

Chapter 34. Evaluation, Investigations, and Management of Late Effects of Childhood Cancer

Abstract

Musculoskeletal System

Cardiovascular System

Respiratory System

Central Nervous System

Endocrine System

Genitourinary System

Ocular System

Auditory System

Gastrointestinal System

Immunologic System

Obesity

Second Malignant Neoplasms

Psychosocial Issues

Further Reading and References

Chapter 35. Psychosocial Aspects of Cancer for Children and Their Families

Abstract

Time of Diagnosis

Treatment Initiation

Illness Stabilization

During Relapses and Recurrences

Treatment Outcomes: The Unsuccessful Course

Treatment Outcomes: The Successful Course

Conclusion

Further Reading and References

Chapter 36. Blood Banking Principles and Practices

Abstract

Introduction

Donor Selection and Collection

Component Preparation

Blood Component Modifications

Special Pediatric Population Needs

Administration

Summary

Further Reading and References

Appendix 1. Hematological Reference Values

Fetal and Cord Blood Hematologic Value

Red Cell Values and Related Serum Values

White Cell Values

Platelet Values

Coagulation Values

Bone Marrow Cells

Appendix 2. Biological Tumor Markers

Index


An aparitie 2016
Autor Philip Lanzkowsky, Jeffrey M. Lipton , Jonathan D. Fish
Dimensiuni 22,4 x 4,3 x 27,7 cm
Editura Elsevier
Format Hardback
ISBN 9780128013687
Limba Engleza
Nr pag 788

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