BRS Biochemistry, Molecular Biology, and Genetics

Description:

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Practical, approachable, and perfect for today’s busy medical students and practitioners, BRS Biochemistry, Molecular Biology, and Genetics, Seventh Edition helps ensure excellence in class exams and on the USMLE Step 1. The popular Board Review Series outline format keeps content succinct and accessible for the most efficient review, accompanied by bolded key terms, detailed figures, quick-reference tables, and other aids that highlight important concepts and reinforce understanding.   This revised edition is updated to reflect the latest perspectives in biochemistry, molecular biology, and genetics, with a clinical emphasis essential to success in practice. New Clinical Correlation boxes detail the real-world application of chapter concepts, and updated USMLE-style questions with answers test retention and enhance preparation for board exams and beyond.

Table of Contents:

1. Fuel Metabolism and Nutrition: Basic Principles

Overview

I. Metabolic Fuels and Dietary Components

II. The Fed or Absorptive State

III. Fasting

IV. Prolonged Fasting (Starvation)

Review Test

2. Basic Aspects of Biochemistry: Organic Chemistry, Acid–Base Chemistry, Amino Acids, Protein Structure and Function, and Enzyme Kinetics

Overview

I. A Brief Review of Organic Chemistry

II. Acids, Bases, and Buffers

III. Amino Acids and Peptide Bonds

IV. Protein Structure

V. Enzymes

Review Test

3. Gene Expression (Transcription), Synthesis of Proteins (Translation), and Regulation of Gene Expression

Overview

I. Nucleic Acid Structure

II. Synthesis of DNA (Replication)

III. Synthesis of RNA (Transcription)

IV. Protein Synthesis (Translation of mRNA)

V. Regulation of Protein Synthesis

VI. Recombinant DNA and Medicine

Review Test

4. Cell Biology, Signal Transduction, and the Molecular Biology of Cancer

Overview

I. Compartmentation in Cells: Cell Biology and Biochemistry

II. Cell Signaling by Chemical Messengers

III. The Molecular Biology of Cancer

IV. Cancer and Apoptosis

V. Cancer Requires Multiple Mutations

VI. Viruses and Human Cancer

Review Test

5. Generation of Atp from Metabolic Fuels and Oxygen Toxicity

Overview

I. Bioenergetics

II. Properties of Adenosine Triphosphate

III. Electron Carriers and Vitamins

IV. Tricarboxylic Acid Cycle

V. Electron Transport Chain and Oxidative Phosphorylation

VI. Oxygen Toxicity and Free-Radical Injury

Review Test

6. Carbohydrate Metabolism

Overview

I. Carbohydrate Structure

II. Proteoglycans, Glycoproteins, and Glycolipids

III. Digestion of Carbohydrates

IV. Glycogen Structure and Metabolism

V. Glycolysis

VI. Gluconeogenesis

VII. Fructose and Galactose Metabolism

VIII. Pentose Phosphate Pathway

IX. Maintenance of Blood Glucose Levels

Review Test

7. Lipid and Ethanol Metabolism

Overview

I. Lipid Structure

II. Membranes

III. Digestion of Dietary Triacylglycerol

IV. Fatty Acid and Triacylglycerol Synthesis

V. Formation of Triacylglycerol Stores in Adipose Tissue

VI. Cholesterol and Bile Salt Metabolism

VII. Blood Lipoproteins

VIII. Fate of Adipose Triacylglycerols

IX. Fatty Acid Oxidation

X. Ketone Body Synthesis and Utilization

XI. Phospholipid and Sphingolipid Metabolism

XII. Metabolism of the Eicosanoids

XIII. Ethanol Metabolism

Review Test

8. Nitrogen Metabolism: Amino Acids, Purines, Pyrimidines, and Products Derived from Amino Acids

Overview

I. Protein Digestion and Amino Acid Absorption

II. Addition and Removal of Amino Acid Nitrogen

III. Urea Cycle

IV. Synthesis and Degradation of Amino Acids

V. Interrelationships of Various Tissues in Amino Acid Metabolism

VI. Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine

VII. Special Products Derived from Amino Acids

Review Test

9 Molecular Endocrinology and an Overview of Tissue Metabolism

Overview

I. Synthesis of Hormones

II. General Mechanisms of Hormone Action

III. Regulation of Hormone Levels

IV. Actions of Specific Hormones

V. Biochemical Functions of Tissues

Review Test

10. Human Genetics—An Introduction

Overview

I. Mendelian Inheritance Patterns

II. Genes

III. Mutations

IV. Inheritance Patterns

V. A Summary of Inheritance Patterns

VI. Cytogenetics

VII. Population Genetics

VIII. Multifactorial Diseases (Complex Traits)

IX. Triplet Repeat Expansions

X. Imprinting

XI. Epigenetics

XII. The Genetics of Tumor Suppressors

XIII. Metabolic Genetic Disorders Involving Carbohydrate and Lipid Pathways

Review Test

Comprehensive Examination

Index