Biopsy Interpretation of the Prostate
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Autor: Jonathan I. Epstein
Editura: Lippincott Williams and Wilkins
Limba: Engleza
Nr. pagini: 456
Coperta: Hardcover
Dimensiuni: 15.3 x 2.3 x 22.9 cm
An aparitie: 2020
- Focuses on practical, need-to-know information regarding the diagnosis and prognosis of prostate cancer obtained on biopsy, addressing both common and unusual issues that arise in day-to-day practice.
- Provides new information on noninvasive lesions (HGPIN and intraductal carcinoma), clinical correlates with biopsy, and practical molecular findings.
- Shows how to critically use adjunctive tests to both diagnose limited prostate cancer and avoid overdiagnosing mimickers of prostate cancer.
- Emphasizes the newest updates in prostate cancer grading so that you can provide the most accurate prognostication in your biopsy reports.
- Features 1800 images online, as well as a 50-question test bank for self-assessment and review.
· 1 Clinical Correlates with Biopsy: Serum Prostate-Specific Antigen, Digital Rectal Examination, and Imaging Techniques
· DIGITAL RECTAL EXAMINATION
· IMAGING TECHNIQUES
· PROSTATE-SPECIFIC ANTIGEN
· Total Serum Prostate-Specific Antigen
· Prostate-Specific Antigen Density
· Age-Specific Prostate-Specific Antigen Reference Ranges
· Prostate-Specific Antigen Velocity (Rate of Change of Prostate-Specific Antigen)
· Molecular Forms of Prostate-Specific Antigen
· Other Prostate Serum and Urine Markers
· Prostate-Specific Antigen Factored into TNM Staging
· Prostate-Specific Antigen Relation to Post-therapy Follow-up Biopsies
· 2 Needle Biopsy Technique, Tissue Sampling, and Processing of Needle Biopsy and Transurethral Resection Specimens
· NEEDLE BIOPSY TECHNIQUE
· NEEDLE BIOPSY PROCESSING—FIXATIVE
· NEEDLE BIOPSY PROCESSING—NUMBER OF LEVELS
· NEEDLE BIOPSY PROCESSING—INTERVENING UNSTAINED SLIDES
· NEEDLE BIOPSY PROCESSING—NUMBER OF TISSUE CORES PER BLOCK/SLIDE
· NEEDLE BIOPSY—INKING THE PERIPHERAL END OF THE CORE
· SAMPLING OF TRANSURETHRAL RESECTION SPECIMENS
· 3 Gross Anatomy and Normal Histology
· GROSS ANATOMY
· HISTOLOGY
· BENIGN PROSTATIC HYPERTROPHY
· 4 Inflammatory Conditions
· ACUTE AND CHRONIC PROSTATIC INFLAMMATION
· MALAKOPLAKIA
· SARCOIDOSIS
· GRANULOMATOUS PROSTATITIS
· MYCOTIC PROSTATITIS
· MYCOBACTERIAL PROSTATITIS
· NONSPECIFIC GRANULOMATOUS PROSTATITIS
· POSTBIOPSY GRANULOMAS
· SYSTEMIC GRANULOMATOUS PROSTATITIS
· MISCELLANEOUS INFECTIONS
· 5 Noninvasive Lesions in the Prostate: Prostatic Intraepithelial Neoplasia and Intraductal Carcinoma of the Prostate
· PROSTATIC INTRAEPITHELIAL NEOPLASIA
· Evidence Linking Prostatic Intraepithelial Neoplasia to Cancer
· Mimickers of Prostatic Intraepithelial Neoplasia
· Low-Grade Prostatic Intraepithelial Neoplasia: Risk of Cancer on Rebiopsy
· High-Grade Prostatic Intraepithelial Neoplasia: Incidence on Biopsy
· High-Grade Prostatic Intraepithelial Neoplasia on Biopsy: Overall Risk of Cancer
· High-Grade Prostatic Intraepithelial Neoplasia on Biopsy: Risk of Cancer Stratified by Clinical Predictors
· High-Grade Prostatic Intraepithelial Neoplasia on Biopsy: Risk of Cancer Stratified by Pathologic Predictors
· High-Grade Prostatic Intraepithelial Neoplasia on Biopsy: Repeat Biopsy Strategy and Technique
· High-Grade Prostatic Intraepithelial Neoplasia: Significance on Transurethral Resection of the Prostate Material
· High-Grade Prostatic Intraepithelial Neoplasia on Biopsy: Findings at Subsequent Radical Prostatectomy
· INTRADUCTAL CARCINOMA OF THE PROSTATE
· Incidence of Intraductal Carcinoma of the Prostate
· Differential Diagnosis of Intraductal Carcinoma of the Prostate
· Significance of Intraductal Carcinoma of the Prostate on Biopsy
· 6 Diagnosis of Limited Adenocarcinoma of the Prostate
· DIAGNOSIS ON NEEDLE BIOPSY
· General Principles in Diagnosing Prostate Cancer
· ARCHITECTURAL FEATURES IN THE DIAGNOSIS OF CANCER
· NUCLEAR FEATURES IN THE DIAGNOSIS OF CANCER
· CYTOPLASMIC FEATURES IN THE DIAGNOSIS OF CANCER
· INTRALUMINAL CONTENTS IN THE DIAGNOSIS OF CANCER
· STROMAL CHANGES
· HISTOLOGIC FEATURES SPECIFIC FOR PROSTATE CANCER
· IDENTIFICATION OF BASAL CELLS ON H&E-STAINED SECTIONS
· DIAGNOSIS OF LIMITED HIGH-GRADE CARCINOMA
· CARCINOMAS MIMICKING BENIGN GLANDS
· DIAGNOSIS OF CANCER ON TRANSURETHRAL RESECTION
· USE OF IMMUNOHISTOCHEMICAL ADJUNCTIVE TESTS FOR DIAGNOSIS OF CARCINOMA
· 7 Mimickers of Prostate Adenocarcinoma
· MIMICKERS OF GLEASON PATTERN 3 ADENOCARCINOMA
· Adenosis
· Diffuse Adenosis of the Peripheral Zone
· Atrophy
· Basal Cell Hyperplasia
· Colonic Mucosa
· Cowper Glands
· Mesonephric Hyperplasia
· Nephrogenic Adenoma
· Radiation Atypia
· Seminal Vesicles
· Verumontanum Mucosal Gland Hyperplasia
· MIMICKERS OF GLEASON PATTERNS 4 AND 5 ADENOCARCINOMA
· Clear Cell Cribriform Hyperplasia
· Nonspecific Granulomatous Prostatitis
· Paraganglia
· Sclerosing Adenosis
· Signet Ring Lymphocytes
· Xanthoma
· 8 Reporting Cancer: Influence on Prognosis and Treatment
· NEEDLE BIOPSY
· Use of Macros (Canned Text)
· Quantification of Amount of Cancer on Needle Biopsy
· LOCATION OF POSITIVE BIOPSY CORES
· PERINEURAL INVASION
· LYMPHOVASCULAR INVASION
· USE OF NOMOGRAMS
· DIRECT STAGING ON NEEDLE BIOPSY
· TRANSURETHRAL RESECTION
· Subclassification
· 9 Grading of Prostatic Adenocarcinomas
· HISTORICAL BACKGROUND
· INTERNATIONAL SOCIETY OF UROLOGICAL PATHOLOGY MODIFICATIONS TO GLEASON GRADING
· 2005 International Society of Urological Pathology Consensus Conference
· 2014 International Society of Urological Pathology Consensus Conference
· GENERAL APPLICATIONS OF THE GLEASON GRADING SYSTEM
· GLEASON PATTERNS
· Historical Gleason Patterns 1 and 2
· Gleason Pattern 3
· Gleason Pattern 4
· Gleason Pattern 5
· GRADING VARIANTS OF PROSTATE CARCINOMA
· Adenocarcinoma with Vacuoles
· Foamy Gland Carcinoma
· Pseudohyperplastic Adenocarcinoma
· REPORTING GLEASON GRADE ON BIOPSY
· Different Cores with Different Grades
· Tertiary Gleason Patterns
· Reporting Secondary Patterns of Higher Grade When Present to a Limited Extent
· Reporting Secondary Patterns of Lower Grade When Present to a Limited Extent
· Reporting Percentage Pattern 4 on Needle Biopsies
· CORRELATION NEEDLE BIOPSY AND RADICAL PROSTATECTOMY GRADE
· Explanations for Grading Discrepancies
· Factors Associated with Increased Upgrading and Downgrading from Biopsy to Prostatectomy
· INTEROBSERVER REPRODUCIBILITY
· GLEASON GRADE GROUPING
· CHANGE OF GRADE OVER TIME
· USE OF ARTIFICIAL INTELLIGENCE FOR GRADING
· 10 Findings of Atypical Glands Suspicious for Cancer
· INCIDENCE OF ATYPICAL DIAGNOSIS ON NEEDLE BIOPSY
· INTEROBSERVER REPRODUCIBILITY
· PROSTATE CANCER RISK FOLLOWING A DIAGNOSIS OF ATYPIA
· RADICAL PROSTATECTOMY AFTER CANCER DIAGNOSED POSTATYPICAL BIOPSY
· REBIOPSY TECHNIQUES FOLLOWING A DIAGNOSIS OF ATYPIA
· HISTOLOGY–ATYPICAL SMALL GLANDS
· 11 Prostatic Duct Adenocarcinoma
· 12 Neuroendocrine Differentiation in the Benign and Malignant Prostate
· NEUROENDOCRINE CELLS IN NORMAL PROSTATE HISTOLOGY
· NEUROENDOCRINE CELLS AND DIFFERENTIATION IN PROSTATE CANCER
· USUAL PROSTATE ADENOCARCINOMA WITH NEUROENDOCRINE DIFFERENTIATION
· ADENOCARCINOMA WITH PANETH CELL-LIKE NEUROENDOCRINE DIFFERENTIATION
· CARCINOID TUMOR
· SMALL CELL CARCINOMA
· LARGE CELL NEUROENDOCRINE CARCINOMA
· MIXED NEUROENDOCRINE CARCINOMA–ACINAR ADENOCARCINOMA
· PROSTATE CARCINOMA WITH OVERLAPPING FEATURES OF SMALL CELL AND ACINAR ADENOCARCINOMA
· CASTRATE-RESISTANT PROSTATE CANCER WITH SMALL CELL CARCINOMA–LIKE CLINICAL PRESENTATION
· 13 Mucinous Differentiation in the Benign and Malignant Prostate
· MUCINOUS ADENOCARCINOMA OF THE PROSTATE
· PROSTATIC URETHRAL ADENOCARCINOMA
· 14 Benign and Malignant Prostate following Treatment
· ANTIANDROGEN THERAPY
· RADIATION
· POSTRADICAL PROSTATECTOMY BIOPSIES
· EMERGING FOCAL/ABLATIVE THERAPIES
· Cryotherapy
· High-Intensity Frequency Ultrasound
· Vascular-Targeted Photodynamic Therapy
· HYPERTHERMIA
· PHYTOTHERAPY
· POST-TEFLON INJECTION GRANULOMAS
· POSTNEEDLE BIOPSY CHANGES
· 15 Urothelial Carcinoma
· DISTINCTION OF HIGH-GRADE PROSTATIC ADENOCARCINOMA FROM UROTHELIAL CARCINOMA
· PROSTATIC INTRADUCTAL UROTHELIAL CARCINOMA WITH OR WITHOUT PROSTATIC STROMAL INVASION
· UROTHELIAL CARCINOMA SEEN ON NEEDLE BIOPSY
· PRIMARY UROTHELIAL CARCINOMA
· 16 Mesenchymal Tumors and Tumor-like Conditions
· STROMAL TUMORS OF UNCERTAIN MALIGNANT POTENTIAL AND STROMAL SARCOMAS
· LEIOMYOMA/LEIOMYOSARCOMA
· INFLAMMATORY MYOFIBROBLASTIC TUMOR
· SOLITARY FIBROUS TUMOR
· GASTROINTESTINAL STROMAL TUMOR
· RHABDOMYOSARCOMA
· MISCELLANEOUS
· 17 Miscellaneous Benign and Malignant Lesions
· BENIGN LESIONS
· Prostatic Cysts
· Multilocular Cysts of the Prostate (Multilocular Prostatic Cystadenoma)
· Melanotic Lesions
· Amyloid
· Calculi and Calcification
· Infarcts
· Miscellaneous
· MALIGNANT LESIONS
· Basal Cell Carcinomas
· Carcinomas with Squamous Differentiation
· Sarcomatoid Carcinoma
· Hematopoietic Tumors
· Miscellaneous Primary Tumors
· Involvement of the Prostate by Secondary Tumors
· 18 Prostatic Urethral Lesions
· PROSTATIC URETHRAL POLYPS
· MISCELLANEOUS URETHRAL POLYPS
· NEPHROGENIC ADENOMAS
· INVERTED PAPILLOMA OF THE PROSTATIC URETHRA
· MISCELLANEOUS
· 19 Tissue-based Biomarkers Using Needle Biopsy Material
· COMMERCIAL GENOMIC ASSAYS
· PTEN LOSS
· Germ Line Testing for DNA Damage Repair Genes
· HOXB13
· MOLECULAR SPECIMEN IDENTITY TESTING
An aparitie | 2020 |
Autor | Jonathan I. Epstein |
Dimensiuni | 15.3 x 2.3 x 22.9 cm |
Editura | Lippincott Williams and Wilkins |
Format | Hardcover |
ISBN | 9781975136543 |
Limba | Engleza |
Nr pag | 456 |
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